FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981375992> ?p ?o ?g. }

• W2981375992 endingPage "376" @default.
• W2981375992 startingPage "365" @default.
• W2981375992 abstract "Abstract Spheroid‐based systems have been developed as alternatives to two‐dimensional (2D) monolayer cultures for understanding 3D cell behavior and conducting in vitro drug screening tests. However, spheroids are easily disrupted while handling and do not mimic the presence of extracellular matrix (ECM) components. To address that, we have developed a cost‐effective, polyethylene glycol diacrylate (PEGDA), and gelatin methacryloyl (GELMA) based semi‐synthetic cryogel matrix system, which can be used to grow spheroids and conduct studies while providing architectural support and mimicking in vivo ECM components. These matrices are macroporous and support formation of tumor‐like spheroids of breast tumor epithelial (MCF‐7) cells in the absence of additional growth factors otherwise required for spheroid formation. Difference in morphology of cells as a function of matrix composition and increase in size and number of spheroids as a function of time was observed. Spheroids grown in cryogel matrices showed more drug resistance than their 2D counterparts, which can partially be explained by the epithelial to mesenchymal transition (EMT) observed in spheroids. We believe that spheroids formed through these PEGDA–GELMA cryogel matrices better represent in vivo pathological conditions and can help develop cost‐effective in vitro assays for screening new pharmacological drug candidates and performing cell mechanistic studies." @default.
• W2981375992 created "2019-11-01" @default.
• W2981375992 creator A5016885745 @default.
• W2981375992 creator A5040041354 @default.
• W2981375992 date "2019-11-07" @default.
• W2981375992 modified "2023-10-17" @default.
• W2981375992 title "Three‐dimensional cryogel matrix for spheroid formation and anti‐cancer drug screening" @default.
• W2981375992 cites W1795050634 @default.
• W2981375992 cites W1965975485 @default.
• W2981375992 cites W1967637263 @default.
• W2981375992 cites W1968743655 @default.
• W2981375992 cites W1973375556 @default.
• W2981375992 cites W2000053231 @default.
• W2981375992 cites W2004673921 @default.
• W2981375992 cites W2007398005 @default.
• W2981375992 cites W2015139117 @default.
• W2981375992 cites W2016228935 @default.
• W2981375992 cites W2016325779 @default.
• W2981375992 cites W2065629669 @default.
• W2981375992 cites W2072371349 @default.
• W2981375992 cites W2075113673 @default.
• W2981375992 cites W2087037684 @default.
• W2981375992 cites W2091262660 @default.
• W2981375992 cites W2105017561 @default.
• W2981375992 cites W2123232388 @default.
• W2981375992 cites W2150322923 @default.
• W2981375992 cites W2154122152 @default.
• W2981375992 cites W2157923000 @default.
• W2981375992 cites W2275011229 @default.
• W2981375992 cites W2291966916 @default.
• W2981375992 cites W2326031573 @default.
• W2981375992 cites W2331628193 @default.
• W2981375992 cites W2332155194 @default.
• W2981375992 cites W2343371293 @default.
• W2981375992 cites W2414503292 @default.
• W2981375992 cites W2460593466 @default.
• W2981375992 cites W2464238702 @default.
• W2981375992 cites W2500989176 @default.
• W2981375992 cites W2503026722 @default.
• W2981375992 cites W2515795587 @default.
• W2981375992 cites W2521953092 @default.
• W2981375992 cites W2588271989 @default.
• W2981375992 cites W2608993677 @default.
• W2981375992 cites W2614838422 @default.
• W2981375992 cites W2752291796 @default.
• W2981375992 cites W2770748109 @default.
• W2981375992 cites W2788914936 @default.
• W2981375992 cites W2791017844 @default.
• W2981375992 cites W2800187340 @default.
• W2981375992 cites W2894354504 @default.
• W2981375992 cites W2913545421 @default.
• W2981375992 cites W2943185211 @default.
• W2981375992 doi "https://doi.org/10.1002/jbm.a.36822" @default.
• W2981375992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31654478" @default.
• W2981375992 hasPublicationYear "2019" @default.
• W2981375992 type Work @default.
• W2981375992 sameAs 2981375992 @default.
• W2981375992 citedByCount "17" @default.
• W2981375992 countsByYear W29813759922020 @default.
• W2981375992 countsByYear W29813759922021 @default.
• W2981375992 countsByYear W29813759922022 @default.
• W2981375992 countsByYear W29813759922023 @default.
• W2981375992 crossrefType "journal-article" @default.
• W2981375992 hasAuthorship W2981375992A5016885745 @default.
• W2981375992 hasAuthorship W2981375992A5040041354 @default.
• W2981375992 hasConcept C106487976 @default.
• W2981375992 hasConcept C12554922 @default.
• W2981375992 hasConcept C136229726 @default.
• W2981375992 hasConcept C150903083 @default.
• W2981375992 hasConcept C159985019 @default.
• W2981375992 hasConcept C163688615 @default.
• W2981375992 hasConcept C175369904 @default.
• W2981375992 hasConcept C185592680 @default.
• W2981375992 hasConcept C189165786 @default.
• W2981375992 hasConcept C192562407 @default.
• W2981375992 hasConcept C202751555 @default.
• W2981375992 hasConcept C207001950 @default.
• W2981375992 hasConcept C2776964284 @default.
• W2981375992 hasConcept C2778823387 @default.
• W2981375992 hasConcept C49892992 @default.
• W2981375992 hasConcept C55493867 @default.
• W2981375992 hasConcept C71924100 @default.
• W2981375992 hasConcept C86803240 @default.
• W2981375992 hasConcept C95444343 @default.
• W2981375992 hasConceptScore W2981375992C106487976 @default.
• W2981375992 hasConceptScore W2981375992C12554922 @default.
• W2981375992 hasConceptScore W2981375992C136229726 @default.
• W2981375992 hasConceptScore W2981375992C150903083 @default.
• W2981375992 hasConceptScore W2981375992C159985019 @default.
• W2981375992 hasConceptScore W2981375992C163688615 @default.
• W2981375992 hasConceptScore W2981375992C175369904 @default.
• W2981375992 hasConceptScore W2981375992C185592680 @default.
• W2981375992 hasConceptScore W2981375992C189165786 @default.
• W2981375992 hasConceptScore W2981375992C192562407 @default.
• W2981375992 hasConceptScore W2981375992C202751555 @default.
• W2981375992 hasConceptScore W2981375992C207001950 @default.
• W2981375992 hasConceptScore W2981375992C2776964284 @default.
• W2981375992 hasConceptScore W2981375992C2778823387 @default.

• next