FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981437653> ?p ?o ?g. }

• W2981437653 endingPage "644" @default.
• W2981437653 startingPage "632" @default.
• W2981437653 abstract "Obesity and osteoarthritis (OA) are 2 major public health issues affecting millions of people worldwide. Whereas parental obesity affects the predisposition to diseases such as cancer or diabetes in children, transgenerational influences on musculoskeletal conditions such as OA are poorly understood. This study was undertaken to assess the intergenerational effects of a parental/grandparental high-fat diet on the metabolic and skeletal phenotype, systemic inflammation, and predisposition to OA in 2 generations of offspring in mice.Metabolic phenotype and predisposition to OA were investigated in the first and second (F1 and F2) generations of offspring (n = 10-16 mice per sex per diet) bred from mice fed a high-fat diet (HFD) or a low-fat control diet. OA was induced by destabilizing the medial meniscus. OA, synovitis, and adipose tissue inflammation were determined histologically, while bone changes were measured using micro-computed tomography. Serum and synovial cytokines were measured by multiplex assay.Parental high-fat feeding showed an intergenerational effect, with inheritance of increased weight gain (up to 19% in the F1 generation and 9% in F2), metabolic imbalance, and injury-induced OA in at least 2 generations of mice, despite the fact that the offspring were fed the low-fat diet. Strikingly, both F1 and F2 female mice showed an increased predisposition to injury-induced OA (48% higher predisposition in F1 and 19% in F2 female mice fed the HFD) and developed bone microarchitectural changes that were attributable to parental and grandparental high-fat feeding.The results of this study reveal a detrimental effect of parental HFD and obesity on the musculoskeletal integrity of 2 generations of offspring, indicating the importance of further investigation of these effects. An improved understanding of the mechanisms involved in the transmissibility of diet-induced changes through multiple generations may help in the development of future therapies that would target the effects of obesity on OA and related conditions." @default.
• W2981437653 created "2019-11-01" @default.
• W2981437653 creator A5037823658 @default.
• W2981437653 creator A5041658920 @default.
• W2981437653 creator A5052420029 @default.
• W2981437653 creator A5074041207 @default.
• W2981437653 creator A5089171919 @default.
• W2981437653 creator A5090627153 @default.
• W2981437653 date "2020-03-05" @default.
• W2981437653 modified "2023-09-30" @default.
• W2981437653 title "Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice" @default.
• W2981437653 cites W1796554278 @default.
• W2981437653 cites W1941376969 @default.
• W2981437653 cites W1964333485 @default.
• W2981437653 cites W1977031076 @default.
• W2981437653 cites W1979683246 @default.
• W2981437653 cites W1993119975 @default.
• W2981437653 cites W1999158053 @default.
• W2981437653 cites W2002251686 @default.
• W2981437653 cites W2003342987 @default.
• W2981437653 cites W2007154912 @default.
• W2981437653 cites W2029755525 @default.
• W2981437653 cites W2035472204 @default.
• W2981437653 cites W2047877478 @default.
• W2981437653 cites W2062652371 @default.
• W2981437653 cites W2066828274 @default.
• W2981437653 cites W2077944070 @default.
• W2981437653 cites W2078858259 @default.
• W2981437653 cites W2079317756 @default.
• W2981437653 cites W2094031116 @default.
• W2981437653 cites W2102308673 @default.
• W2981437653 cites W2107277218 @default.
• W2981437653 cites W2108344016 @default.
• W2981437653 cites W2119974097 @default.
• W2981437653 cites W2127373600 @default.
• W2981437653 cites W2141053182 @default.
• W2981437653 cites W2146548807 @default.
• W2981437653 cites W2149161668 @default.
• W2981437653 cites W2192080449 @default.
• W2981437653 cites W2208403490 @default.
• W2981437653 cites W2307809450 @default.
• W2981437653 cites W2344174886 @default.
• W2981437653 cites W2418618550 @default.
• W2981437653 cites W2518476958 @default.
• W2981437653 cites W2523447198 @default.
• W2981437653 cites W2532437410 @default.
• W2981437653 cites W2560580902 @default.
• W2981437653 cites W2583494623 @default.
• W2981437653 cites W2606688118 @default.
• W2981437653 cites W2617548564 @default.
• W2981437653 cites W2618547501 @default.
• W2981437653 cites W2620438853 @default.
• W2981437653 cites W2742227214 @default.
• W2981437653 cites W2745611533 @default.
• W2981437653 cites W2753143217 @default.
• W2981437653 cites W2765832657 @default.
• W2981437653 cites W2799337008 @default.
• W2981437653 cites W2883033946 @default.
• W2981437653 cites W2885411665 @default.
• W2981437653 cites W2888916586 @default.
• W2981437653 cites W2941809984 @default.
• W2981437653 cites W2015602002 @default.
• W2981437653 doi "https://doi.org/10.1002/art.41147" @default.
• W2981437653 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7113102" @default.
• W2981437653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31646754" @default.
• W2981437653 hasPublicationYear "2020" @default.
• W2981437653 type Work @default.
• W2981437653 sameAs 2981437653 @default.
• W2981437653 citedByCount "25" @default.
• W2981437653 countsByYear W29814376532020 @default.
• W2981437653 countsByYear W29814376532021 @default.
• W2981437653 countsByYear W29814376532022 @default.
• W2981437653 countsByYear W29814376532023 @default.
• W2981437653 crossrefType "journal-article" @default.
• W2981437653 hasAuthorship W2981437653A5037823658 @default.
• W2981437653 hasAuthorship W2981437653A5041658920 @default.
• W2981437653 hasAuthorship W2981437653A5052420029 @default.
• W2981437653 hasAuthorship W2981437653A5074041207 @default.
• W2981437653 hasAuthorship W2981437653A5089171919 @default.
• W2981437653 hasAuthorship W2981437653A5090627153 @default.
• W2981437653 hasBestOaLocation W29814376532 @default.
• W2981437653 hasConcept C112672928 @default.
• W2981437653 hasConcept C126322002 @default.
• W2981437653 hasConcept C134018914 @default.
• W2981437653 hasConcept C142724271 @default.
• W2981437653 hasConcept C171089720 @default.
• W2981437653 hasConcept C204787440 @default.
• W2981437653 hasConcept C2776164576 @default.
• W2981437653 hasConcept C2776914184 @default.
• W2981437653 hasConcept C2777077863 @default.
• W2981437653 hasConcept C2779134260 @default.
• W2981437653 hasConcept C2779234561 @default.
• W2981437653 hasConcept C2779244835 @default.
• W2981437653 hasConcept C2780586474 @default.
• W2981437653 hasConcept C42407357 @default.
• W2981437653 hasConcept C511355011 @default.
• W2981437653 hasConcept C54355233 @default.
• W2981437653 hasConcept C67636389 @default.

• next