FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981442138> ?p ?o ?g. }

• W2981442138 endingPage "1075" @default.
• W2981442138 startingPage "1053" @default.
• W2981442138 abstract "Neurons in the rostral ventrolateral medulla (RVLM) regulate blood pressure through direct projections to spinal sympathetic preganglionic neurons. Only some RVLM neurons are active under resting conditions due to significant, tonic inhibition by gamma-aminobutyric acid (GABA). Withdrawal of GABAA receptor-mediated inhibition of the RVLM increases sympathetic outflow and blood pressure substantially, providing a mechanism by which the RVLM could contribute chronically to cardiovascular disease (CVD). Here, we tested the hypothesis that sedentary conditions, a major risk factor for CVD, increase GABAA receptors in RVLM, including its rostral extension (RVLMRE ), both of which contain bulbospinal catecholamine (C1) and non-C1 neurons. We examined GABAA receptor subunits GABAAα1 and GABAAα2 in the RVLM/RVLMRE of sedentary or physically active (10-12 weeks of wheel running) rats. Western blot analyses indicated that sedentary rats had lower expression of GABAAα1 and GABAAα2 subunits in RVLM but only GABAAα2 was lower in the RVLMRE of sedentary rats. Sedentary rats had significantly reduced expression of the chloride transporter, KCC2, suggesting less effective GABA-mediated inhibition compared to active rats. Retrograde tracing plus triple-label immunofluorescence identified fewer bulbospinal non-C1 neurons immunoreactive for GABAAα1 but a higher percentage of bulbospinal C1 neurons immunoreactive for GABAAα1 in sedentary animals. Sedentary conditions did not significantly affect the number of bulbospinal C1 or non-C1 neurons immunoreactive for GABAAα2 . These results suggest a complex interplay between GABAA receptor expression by spinally projecting C1 and non-C1 neurons and sedentary versus physically active conditions. They also provide plausible mechanisms for both enhanced sympathoexcitatory and sympathoinhibitory responses following sedentary conditions." @default.
• W2981442138 created "2019-11-01" @default.
• W2981442138 creator A5026591169 @default.
• W2981442138 creator A5031968041 @default.
• W2981442138 creator A5036529501 @default.
• W2981442138 creator A5038205089 @default.
• W2981442138 date "2019-11-21" @default.
• W2981442138 modified "2023-09-26" @default.
• W2981442138 title "Subregional differences in GABA _A receptor subunit expression in the rostral ventrolateral medulla of sedentary versus physically active rats" @default.
• W2981442138 cites W1843062540 @default.
• W2981442138 cites W1966409424 @default.
• W2981442138 cites W1972078681 @default.
• W2981442138 cites W1972214265 @default.
• W2981442138 cites W1972735490 @default.
• W2981442138 cites W1974011993 @default.
• W2981442138 cites W1978015436 @default.
• W2981442138 cites W1978815996 @default.
• W2981442138 cites W1984546941 @default.
• W2981442138 cites W1986696484 @default.
• W2981442138 cites W1986836226 @default.
• W2981442138 cites W1987163112 @default.
• W2981442138 cites W1991543137 @default.
• W2981442138 cites W1991634082 @default.
• W2981442138 cites W1994240674 @default.
• W2981442138 cites W1997572584 @default.
• W2981442138 cites W2000804333 @default.
• W2981442138 cites W2010702285 @default.
• W2981442138 cites W2016796689 @default.
• W2981442138 cites W2022378061 @default.
• W2981442138 cites W2029123608 @default.
• W2981442138 cites W2029492124 @default.
• W2981442138 cites W2030566507 @default.
• W2981442138 cites W2044288858 @default.
• W2981442138 cites W2056641815 @default.
• W2981442138 cites W2058326838 @default.
• W2981442138 cites W2059173308 @default.
• W2981442138 cites W2063000317 @default.
• W2981442138 cites W2072283547 @default.
• W2981442138 cites W2074718841 @default.
• W2981442138 cites W2075267148 @default.
• W2981442138 cites W2078069142 @default.
• W2981442138 cites W2086126018 @default.
• W2981442138 cites W2091486815 @default.
• W2981442138 cites W2099520843 @default.
• W2981442138 cites W2100762371 @default.
• W2981442138 cites W2102281369 @default.
• W2981442138 cites W2102555474 @default.
• W2981442138 cites W2107558740 @default.
• W2981442138 cites W2120853935 @default.
• W2981442138 cites W2139596527 @default.
• W2981442138 cites W2144762547 @default.
• W2981442138 cites W2149782516 @default.
• W2981442138 cites W2151429049 @default.
• W2981442138 cites W2155615145 @default.
• W2981442138 cites W2161345915 @default.
• W2981442138 cites W2168971224 @default.
• W2981442138 cites W2169738910 @default.
• W2981442138 cites W2189678019 @default.
• W2981442138 cites W2290580228 @default.
• W2981442138 cites W2295259062 @default.
• W2981442138 cites W2336876471 @default.
• W2981442138 cites W2486831830 @default.
• W2981442138 cites W2504785609 @default.
• W2981442138 cites W2593950464 @default.
• W2981442138 cites W2612993534 @default.
• W2981442138 cites W2783729817 @default.
• W2981442138 cites W2883164167 @default.
• W2981442138 cites W2894695827 @default.
• W2981442138 cites W2902887272 @default.
• W2981442138 cites W307339529 @default.
• W2981442138 doi "https://doi.org/10.1002/cne.24798" @default.
• W2981442138 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7046220" @default.
• W2981442138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31642070" @default.
• W2981442138 hasPublicationYear "2019" @default.
• W2981442138 type Work @default.
• W2981442138 sameAs 2981442138 @default.
• W2981442138 citedByCount "4" @default.
• W2981442138 countsByYear W29814421382021 @default.
• W2981442138 countsByYear W29814421382023 @default.
• W2981442138 crossrefType "journal-article" @default.
• W2981442138 hasAuthorship W2981442138A5026591169 @default.
• W2981442138 hasAuthorship W2981442138A5031968041 @default.
• W2981442138 hasAuthorship W2981442138A5036529501 @default.
• W2981442138 hasAuthorship W2981442138A5038205089 @default.
• W2981442138 hasBestOaLocation W29814421382 @default.
• W2981442138 hasConcept C126322002 @default.
• W2981442138 hasConcept C134018914 @default.
• W2981442138 hasConcept C168258287 @default.
• W2981442138 hasConcept C169760540 @default.
• W2981442138 hasConcept C170493617 @default.
• W2981442138 hasConcept C185592680 @default.
• W2981442138 hasConcept C2778110749 @default.
• W2981442138 hasConcept C33114225 @default.
• W2981442138 hasConcept C529278444 @default.
• W2981442138 hasConcept C71924100 @default.
• W2981442138 hasConcept C86803240 @default.
• W2981442138 hasConcept C9224880 @default.
• W2981442138 hasConceptScore W2981442138C126322002 @default.

• next