FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981461482> ?p ?o ?g. }

• W2981461482 endingPage "2861" @default.
• W2981461482 startingPage "2850" @default.
• W2981461482 abstract "Regulatory T cells (Tregs) play important roles in limiting inflammatory responses in the periphery. During these responses, Treg abundance in affected organs increases and interfering with their recruitment results in exacerbation of inflammation. However, the mechanisms whereby Tregs enter the skin remain poorly understood. The aim of this study was to use intravital microscopy to investigate adhesion and transmigration of Tregs in the dermal microvasculature in a two-challenge model of contact sensitivity. Using intravital confocal microscopy of Foxp3-GFP mice, we visualized endogenous Tregs and assessed their interactions in the dermal microvasculature. Four hours after hapten challenge, Tregs underwent adhesion with ∼25% of these cells proceeding to transmigration, a process dependent on CCR4. At 24 h, Tregs adhered but no longer underwent transmigration, instead remaining in prolonged contact with the endothelium, migrating over the endothelial surface. Four hours after a second challenge, Treg transmigration was restored, although in this case transmigration was CCR4 independent, instead involving the CCR6/CCL20 pathway. Notably, at 24 h but not 4 h after challenge, endothelial cells expressed MHC class II (MHC II). Moreover, at this time of peak MHC II expression, inhibition of MHC II reduced Treg adhesion, demonstrating an unexpected role for MHC II in Treg attachment to the endothelium. Together these data show that Treg adhesion and transmigration can be driven by different molecular mechanisms at different stages of an Ag-driven inflammatory response. In addition, Tregs can undergo prolonged migration on the inflamed endothelium." @default.
• W2981461482 created "2019-11-01" @default.
• W2981461482 creator A5009218688 @default.
• W2981461482 creator A5018689504 @default.
• W2981461482 creator A5022756309 @default.
• W2981461482 creator A5033449939 @default.
• W2981461482 creator A5040346731 @default.
• W2981461482 date "2019-12-01" @default.
• W2981461482 modified "2023-09-24" @default.
• W2981461482 title "Regulatory T Cell Transmigration and Intravascular Migration Undergo Mechanistically Distinct Regulation at Different Phases of the Inflammatory Response" @default.
• W2981461482 cites W1486722793 @default.
• W2981461482 cites W1501511128 @default.
• W2981461482 cites W1510335744 @default.
• W2981461482 cites W1526275690 @default.
• W2981461482 cites W1529674123 @default.
• W2981461482 cites W1563859829 @default.
• W2981461482 cites W1598147941 @default.
• W2981461482 cites W1901366240 @default.
• W2981461482 cites W1956616902 @default.
• W2981461482 cites W1971505103 @default.
• W2981461482 cites W1981265231 @default.
• W2981461482 cites W1982805461 @default.
• W2981461482 cites W2002726823 @default.
• W2981461482 cites W2014540704 @default.
• W2981461482 cites W2035809865 @default.
• W2981461482 cites W2042622644 @default.
• W2981461482 cites W2064218663 @default.
• W2981461482 cites W2065644494 @default.
• W2981461482 cites W2065734967 @default.
• W2981461482 cites W2068521142 @default.
• W2981461482 cites W2069399018 @default.
• W2981461482 cites W2074281049 @default.
• W2981461482 cites W2075870856 @default.
• W2981461482 cites W2076614588 @default.
• W2981461482 cites W2094795241 @default.
• W2981461482 cites W2094854776 @default.
• W2981461482 cites W2095643922 @default.
• W2981461482 cites W2095904729 @default.
• W2981461482 cites W2097233083 @default.
• W2981461482 cites W2097863119 @default.
• W2981461482 cites W2100347808 @default.
• W2981461482 cites W2101026205 @default.
• W2981461482 cites W2101084939 @default.
• W2981461482 cites W2103208539 @default.
• W2981461482 cites W2111292063 @default.
• W2981461482 cites W2112777571 @default.
• W2981461482 cites W2113765099 @default.
• W2981461482 cites W2120459807 @default.
• W2981461482 cites W2128709404 @default.
• W2981461482 cites W2130486201 @default.
• W2981461482 cites W2135498185 @default.
• W2981461482 cites W2138161786 @default.
• W2981461482 cites W2147778626 @default.
• W2981461482 cites W2153349227 @default.
• W2981461482 cites W2153389047 @default.
• W2981461482 cites W2167279371 @default.
• W2981461482 cites W2171880654 @default.
• W2981461482 cites W2266688184 @default.
• W2981461482 cites W2477003746 @default.
• W2981461482 cites W2552808209 @default.
• W2981461482 cites W2787191512 @default.
• W2981461482 doi "https://doi.org/10.4049/jimmunol.1900447" @default.
• W2981461482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31653684" @default.
• W2981461482 hasPublicationYear "2019" @default.
• W2981461482 type Work @default.
• W2981461482 sameAs 2981461482 @default.
• W2981461482 citedByCount "10" @default.
• W2981461482 countsByYear W29814614822020 @default.
• W2981461482 countsByYear W29814614822021 @default.
• W2981461482 countsByYear W29814614822022 @default.
• W2981461482 countsByYear W29814614822023 @default.
• W2981461482 crossrefType "journal-article" @default.
• W2981461482 hasAuthorship W2981461482A5009218688 @default.
• W2981461482 hasAuthorship W2981461482A5018689504 @default.
• W2981461482 hasAuthorship W2981461482A5022756309 @default.
• W2981461482 hasAuthorship W2981461482A5033449939 @default.
• W2981461482 hasAuthorship W2981461482A5040346731 @default.
• W2981461482 hasBestOaLocation W29814614821 @default.
• W2981461482 hasConcept C134018914 @default.
• W2981461482 hasConcept C150903083 @default.
• W2981461482 hasConcept C178790620 @default.
• W2981461482 hasConcept C185592680 @default.
• W2981461482 hasConcept C203014093 @default.
• W2981461482 hasConcept C207001950 @default.
• W2981461482 hasConcept C207936829 @default.
• W2981461482 hasConcept C2776914184 @default.
• W2981461482 hasConcept C2776992346 @default.
• W2981461482 hasConcept C2779727006 @default.
• W2981461482 hasConcept C2859252 @default.
• W2981461482 hasConcept C84416704 @default.
• W2981461482 hasConcept C86803240 @default.
• W2981461482 hasConcept C8891405 @default.
• W2981461482 hasConcept C95444343 @default.
• W2981461482 hasConceptScore W2981461482C134018914 @default.
• W2981461482 hasConceptScore W2981461482C150903083 @default.
• W2981461482 hasConceptScore W2981461482C178790620 @default.
• W2981461482 hasConceptScore W2981461482C185592680 @default.
• W2981461482 hasConceptScore W2981461482C203014093 @default.

• next