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• W2981485464 abstract "In the current investigation, the role of drug–polymer hydrogen bonding (H-bonding) with respect to the phase behavior of amorphous solid dispersions (ASDs) is studied in depth on a nanometer level. Melt-quenched dispersions of felodipine (FEL) with poly(vinylpyrrolidone), or PVP, poly(vinylpyrrolidone-co-vinylacetate), or PVP/VA, and poly(vinylacetate), or PVAc, were prepared at drug loadings of 50–90% w/w. Modulated differential scanning calorimetry (MDSC) was used to detect microscopic homogeneity for each set of ASDs. A single composition dependent glass transition temperature (Tg) was observed over the entire composition range in MDSC data for each set of ASDs; however some samples within each set of ASDs showed a crystallization exotherm and corresponding melting endotherm in the first heating scan. Solid-state nuclear magnetic resonance spectroscopy (SSNMR) was further employed to understand phase homogeneity in these systems. The proton spin–lattice relaxation times in the laboratory and rotating frame (1H T1 and T1ρ) for the drug and individual polymer for each set of ASDs were measured to evaluate phase homogeneity. On the basis of proton relaxation measurements, it was revealed that FEL:PVP and FEL:PVP/VA ASDs exhibited better compositional homogeneity than FEL:PVAc ASDs. The strength and the extent of H-bonding were studied by using 13C SSNMR spectra. In addition, deconvolution of the carbonyl region of amorphous FEL revealed that 40% of amorphous FEL molecules were hydrogen bonded (H-bonded) through dimers and the remaining 60% were free/non H-bonded. The dimer fraction decreased as the polymer content increased for each set of ASDs, while the free fraction increased. This indicated that the polymers containing hydrogen bond acceptor groups disrupted dimers and formed intermolecular H-bonding interactions with FEL. The strength and extent of FEL:polymer H-bonding was rank ordered as PVP > PVP/VA > PVAc. These findings were also confirmed through DFT calculations on these systems. Our results suggest that drug–polymer H-bonding interaction may impact the phase homogeneity in ASDs formulated by a specific method. The data from the current study further demonstrate that SSNMR is a powerful tool for characterizing phase homogeneity in ASDs with sub-50 nm resolution. In addition, SSNMR can provide insights into drug–polymer interactions and speciation in ASDs." @default.
• W2981485464 created "2019-11-01" @default.
• W2981485464 creator A5007624826 @default.
• W2981485464 creator A5008998157 @default.
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• W2981485464 date "2019-10-21" @default.
• W2981485464 modified "2023-10-14" @default.
• W2981485464 title "Phase Behavior of Amorphous Solid Dispersions of Felodipine: Homogeneity and Drug–Polymer Interactions" @default.
• W2981485464 cites W109389496 @default.
• W2981485464 cites W1523881171 @default.
• W2981485464 cites W1741087533 @default.
• W2981485464 cites W1804383856 @default.
• W2981485464 cites W1967843190 @default.
• W2981485464 cites W1968290693 @default.
• W2981485464 cites W1970637466 @default.
• W2981485464 cites W1971275758 @default.
• W2981485464 cites W1979628906 @default.
• W2981485464 cites W1981547314 @default.
• W2981485464 cites W1984009385 @default.
• W2981485464 cites W1988956168 @default.
• W2981485464 cites W1989461604 @default.
• W2981485464 cites W1994893251 @default.
• W2981485464 cites W1999212274 @default.
• W2981485464 cites W2004500944 @default.
• W2981485464 cites W2005893499 @default.
• W2981485464 cites W2008667086 @default.
• W2981485464 cites W2009938495 @default.
• W2981485464 cites W2009961775 @default.
• W2981485464 cites W2011354686 @default.
• W2981485464 cites W2014956897 @default.
• W2981485464 cites W2024934556 @default.
• W2981485464 cites W2027369785 @default.
• W2981485464 cites W2031695780 @default.
• W2981485464 cites W2040432233 @default.
• W2981485464 cites W2041387987 @default.
• W2981485464 cites W2044829159 @default.
• W2981485464 cites W2045300362 @default.
• W2981485464 cites W2049556095 @default.
• W2981485464 cites W2051055753 @default.
• W2981485464 cites W2055230539 @default.
• W2981485464 cites W2055423300 @default.
• W2981485464 cites W2055516309 @default.
• W2981485464 cites W2056434768 @default.
• W2981485464 cites W2069291979 @default.
• W2981485464 cites W2072722160 @default.
• W2981485464 cites W2080856181 @default.
• W2981485464 cites W2081616039 @default.
• W2981485464 cites W2082203116 @default.
• W2981485464 cites W2085535677 @default.
• W2981485464 cites W2094040119 @default.
• W2981485464 cites W2094506063 @default.
• W2981485464 cites W2094642658 @default.
• W2981485464 cites W2107714322 @default.
• W2981485464 cites W2108502789 @default.
• W2981485464 cites W2115682140 @default.
• W2981485464 cites W2143981217 @default.
• W2981485464 cites W2153813502 @default.
• W2981485464 cites W2154404145 @default.
• W2981485464 cites W2164622728 @default.
• W2981485464 cites W2207630120 @default.
• W2981485464 cites W2260808620 @default.
• W2981485464 cites W2304507426 @default.
• W2981485464 cites W2316305032 @default.
• W2981485464 cites W2318545873 @default.
• W2981485464 cites W2330863212 @default.
• W2981485464 cites W2346320316 @default.
• W2981485464 cites W2423995248 @default.
• W2981485464 cites W2468340320 @default.
• W2981485464 cites W2518205318 @default.
• W2981485464 cites W2561397801 @default.
• W2981485464 cites W2587602233 @default.
• W2981485464 cites W2606945242 @default.
• W2981485464 cites W2742631421 @default.
• W2981485464 cites W2912569225 @default.
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• W2981485464 doi "https://doi.org/10.1021/acs.molpharmaceut.9b00731" @default.
• W2981485464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31682129" @default.
• W2981485464 hasPublicationYear "2019" @default.
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