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- W2981486895 abstract "AbstractBackground: Cisplatin is an effective chemotherapeuticagent used in treatment of solid tumors. Cardiotoxicity is oneof the major side effect frequently observed after administrationof cisplatin. Quercetin, an important dietary flavonoid presentin several fruits and vegetables, exhibits antioxidant, antiinflammatoryand anti-cancer properties.Aim of Work: The present work was designed to studythe histological changes in the heart of the adult male albinorat, following administration of cisplatin and the possibleprophylactic role of querectine.Material and Methods: Forty adult male albino rats wereused in this study. They were divided into four groups, tenrats each; Group I (normal control) received nothing, Group II (sham control): Received a daily oral dose of one ml ofnormal saline via gastric gavage. Group III (CP): Receivedintraperitoneal single injection of cisplatin at 15mg/kg doseon the eighth day. Group IV: Querectine has been orallyadministered at 30mg/kg/day dose for one month beginningseven days prior to single cisplatin injection. At the end ofexperiments the heart was removed, and prepared for lightand electron microscopic studies.Results: Cisplatin treated animals (Group III) showedstructural changes in the myocardium in the form of focallesions in many sections and fragmentation of muscle fibers.By electron microscopic examination, mitochondria revealedvariability in size and shape, enlargement (ballooning) withdisturbed cristal pattern. Immunohistochemical study ofmyocardium of Group III animals stained with anti-a-smoothmuscle actin antibody showed positive immunoreactivity.Querectine pretreated animals revealed amelioration in histologicalalterations in the myocardium when compared tocisplatin treated group.Conclusion: This study demonstrated that querectine hada significant effect in protection of the heart against myocardialhistological changes induced by cisplatin." @default.
- W2981486895 created "2019-11-01" @default.
- W2981486895 creator A5073778952 @default.
- W2981486895 date "2018-03-01" @default.
- W2981486895 modified "2023-09-22" @default.
- W2981486895 title "Possible Prophylactic Role of Querctine on Cisplatin-Induced Myocardial Toxicity in Adult Male Albino Rat: Histological and Immunohistochemical Study" @default.
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- W2981486895 doi "https://doi.org/10.21608/mjcu.2018.55139" @default.
- W2981486895 hasPublicationYear "2018" @default.
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