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- W2981493178 abstract "The aim of this study was to identify an objective way to define a long-term survivors (LTS) and short-term survivors (STS) in patients with surgically resected lung adenocarcinoma (ADK), and secondly to find peculiar clinicopathological features in these two groups of patients. all patients who underwent major lung resection for lung ADK from 2000 to 2015 were studied. LTS and STS were extrapolated considering the overall survival (OS) and pathological tumour stage: the first and the fourth quartile of those patients with cancer-related death were considered for statistical analysis. from 600 ADK patients we found 79 STS and 77 LTS;clinico-pathologic baseline characteristics are presented in Table 1.Considering STS patients, smoking habit, histotype, tumour necrosis, pleural invasion and pathological stage were significantly associated with OS at univariate analysis (Fig.1). In LTS patients, smoking habit, neoadjuvant chemotherapy, tumour-infiltrated lymphocytes and pathological stage were significantly associated with OS (Fig.2). On multivariate analysis, smoking status, lymphoid infiltrate, pleural invasion and stage remained significantly associated with OS (Table 2).Table 1VariableFull sampleaSTS (N=79)aLTS (N=77)ap-valueAge at diagnosis (median)68 (62-74)68 (61-74)69 (64-75)0.301Gender (M:F)110:46 (70.5%:29.5%)60:19 (24,1%:75,9%)27:50 (35,1%:64,9%)0.131Smoking status<0.001Never smoker23 (19,6%)5 (6,8%)18 (27,3%)Smoker + Former smoker117 (81,4%)69 (93,2%)48 (72,7%)Other previous primary tumor0.936Yes43 (27,6%)22 (27,8%)21 (27,3%)No113 (72,4%)57 (72,2%)56 (72,7%)Side0.079Right70 (44,9%)30 (38,0%)40 (51,9%)Left86 (55,1%)49 (62,0%)37 (48,1%)Histotype0.085Lepidic5 (3,2%)0 (0,0%)5 (6,5%)Papillary21 (13,5%)11 (13,9%)10 (13,0%)Acinar37 (23,7%)16 (20,3%)21 (27,3%)Micropapillary18 (11,5%)8 (10,1%)10 (13,0%)Solid75 (48,1%)44 (55,7%)31 (40,3%)Grade0.034G12 (1,3%)0 (0,0%)2 (2,6%)G223 (14,7%)7 (8,9%)16 (20,8%)G3131 (84,0%)72 (91,1%)59 (76,6%)Lymphatic invasion0.864Yes101 (64,7%)51 (67,1%)50 (65,8%)No51 (32,7%)25 (32,9%)26 (34,2%)Blood invasion0.128Yes47 (30,1%)28 (36,4%)19 (25,0%)No106 (67,9%)49 (63,6%)57 (75,0%)Pleural invasion0.439PL078 (50,0%)37 (46,8%)41 (53,2%)PL141 (26,3%)24 (30,4%)17 (22,1%)PL220 (12,8%)8 (10,1%)12 (15,6%)PL317 (10,9%)10 (12,7%)7 (9,1%)Necrosis0.419Yes70 (46,7%)37 (50,0%)33 (43,4%)No80 (53,3%)37 (50,0%)43 (56,6%)Lymphoid infiltrate0.787Absent57 (37,0%)27 (35,1%)30 (39,0%)Mild63 (40,9%)34 (44,2%)29 (37,7%)Moderate21 (13,6%)9 (11,7%)12 (15,6%)Marked13 (8,4%)7 (9,1%)6 (7,8%)Neoadjuvant chemotherapy0.371Yes11 (7,1%)7 (8,9%)4 (5,2%)No145 (92,9%)72 (91,1%)73 (94,8%) Open table in a new tab Table 295% CIVariablesp-value.HRSmoking Habit0,0032,3171,3254,052Histotype0,817,951,6201,459Tumor Necrosis0,065,667,4341,025Limphoyd Infiltrate0,0241,5981,0632,402Neoadjuvant CHT0,160,502,1921,313Pleural Invasion0,021,421,201,879Stage0,002,480,305,755 Open table in a new tab Our findings suggest that the unexpected survival of STS and LTS ADK-patients is determined by a concert of clinical and pathological features. Biological characterization of these kind of patients will likely improve the understanding of their unusual course." @default.
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- W2981493178 date "2019-10-01" @default.
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- W2981493178 title "P2.09-02 Exploring the Features of the Short and Long-Term Survivors for Lung Adenocarcinoma: A Single Center Experience" @default.
- W2981493178 doi "https://doi.org/10.1016/j.jtho.2019.08.1651" @default.
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