FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981497166> ?p ?o ?g. }

• W2981497166 abstract "In acidophilic microorganisms, anions like chloride have higher toxicity than their neutrophilic counterparts. In addition to the osmotic imbalance, chloride can also induce acidification of the cytoplasm. We predicted that intracellular acidification produces an increase in respiratory rate and generation of reactive oxygen species, and so oxidative stress can also be induced. In this study, the multifactorial effect as inducing osmotic imbalance, cytoplasm acidification and oxidative stress in the iron-oxidizing bacterium Leptospirillum ferriphilum DSM 14647 exposed to up to 150 mM NaCl was investigated. Results showed that chloride stress up-regulated genes for synthesis of potassium transporters (kdpC and kdpD), and biosynthesis of the compatible solutes (hydroxy)ectoine (ectC and ectD) and trehalose (otsB). As a consequence, the intracellular levels of both hydroxyectoine and trehalose increased significantly, suggesting a strong response to keep osmotic homeostasis. On the other hand, the intracellular pH significantly decreased from 6.7 to pH 5.5 and oxygen consumption increased significantly when the cells were exposed to NaCl stress. Furthermore, this stress condition led to a significant increase of the intracellular content of reactive oxygen species, and to a rise of the antioxidative cytochrome c peroxidase (CcP) and thioredoxin (Trx) activities. In agreement, ccp and trx genes were up-regulated under this condition, suggesting that this bacterium displayed a transcriptionally regulated response against oxidative stress induced by chloride. Altogether, these data reveal that chloride has a dramatic multifaceted effect on acidophile physiology that involves osmotic, acidic and oxidative stresses. Exploration of the adaptive mechanisms to anion stress in iron-oxidizing acidophilic microorganisms may result in new strategies that facilitate the bioleaching of ores for recovery of precious metals in presence of chloride." @default.
• W2981497166 created "2019-11-01" @default.
• W2981497166 creator A5008729408 @default.
• W2981497166 creator A5011780300 @default.
• W2981497166 creator A5032213852 @default.
• W2981497166 creator A5035075327 @default.
• W2981497166 creator A5036254486 @default.
• W2981497166 creator A5038934430 @default.
• W2981497166 date "2019-10-29" @default.
• W2981497166 modified "2023-09-23" @default.
• W2981497166 title "Osmotic Imbalance, Cytoplasm Acidification and Oxidative Stress Induction Support the High Toxicity of Chloride in Acidophilic Bacteria" @default.
• W2981497166 cites W1507573241 @default.
• W2981497166 cites W1523035161 @default.
• W2981497166 cites W1550740130 @default.
• W2981497166 cites W1587170607 @default.
• W2981497166 cites W1593955305 @default.
• W2981497166 cites W1878306483 @default.
• W2981497166 cites W1966420443 @default.
• W2981497166 cites W1972720706 @default.
• W2981497166 cites W1973895766 @default.
• W2981497166 cites W1975675450 @default.
• W2981497166 cites W1979331560 @default.
• W2981497166 cites W1981341991 @default.
• W2981497166 cites W1990727274 @default.
• W2981497166 cites W1991571385 @default.
• W2981497166 cites W2002227116 @default.
• W2981497166 cites W2003853293 @default.
• W2981497166 cites W2006395378 @default.
• W2981497166 cites W2007943975 @default.
• W2981497166 cites W2009561805 @default.
• W2981497166 cites W2011057466 @default.
• W2981497166 cites W2011967714 @default.
• W2981497166 cites W2012110820 @default.
• W2981497166 cites W2012967828 @default.
• W2981497166 cites W2019916357 @default.
• W2981497166 cites W2027574280 @default.
• W2981497166 cites W2029330897 @default.
• W2981497166 cites W2032107787 @default.
• W2981497166 cites W2034638795 @default.
• W2981497166 cites W2045325304 @default.
• W2981497166 cites W2048938232 @default.
• W2981497166 cites W2049087808 @default.
• W2981497166 cites W2049526809 @default.
• W2981497166 cites W2059113460 @default.
• W2981497166 cites W2065642324 @default.
• W2981497166 cites W2070363023 @default.
• W2981497166 cites W2081236930 @default.
• W2981497166 cites W2081643683 @default.
• W2981497166 cites W2086540936 @default.
• W2981497166 cites W2089336118 @default.
• W2981497166 cites W2101882785 @default.
• W2981497166 cites W2102021856 @default.
• W2981497166 cites W2108891383 @default.
• W2981497166 cites W2128635872 @default.
• W2981497166 cites W2137180677 @default.
• W2981497166 cites W2137489734 @default.
• W2981497166 cites W2139183861 @default.
• W2981497166 cites W2147511394 @default.
• W2981497166 cites W2151041036 @default.
• W2981497166 cites W2152239923 @default.
• W2981497166 cites W2163029786 @default.
• W2981497166 cites W2163109978 @default.
• W2981497166 cites W2212946566 @default.
• W2981497166 cites W2240913287 @default.
• W2981497166 cites W2281287171 @default.
• W2981497166 cites W2374948482 @default.
• W2981497166 cites W2402619808 @default.
• W2981497166 cites W2469386895 @default.
• W2981497166 cites W2507663121 @default.
• W2981497166 cites W2522448789 @default.
• W2981497166 cites W2570518027 @default.
• W2981497166 cites W2573864607 @default.
• W2981497166 cites W2575809981 @default.
• W2981497166 cites W2748650171 @default.
• W2981497166 cites W2749689097 @default.
• W2981497166 cites W2801694687 @default.
• W2981497166 cites W2893664476 @default.
• W2981497166 cites W2913837459 @default.
• W2981497166 cites W2928015247 @default.
• W2981497166 cites W2942632736 @default.
• W2981497166 cites W4214911971 @default.
• W2981497166 cites W4244080523 @default.
• W2981497166 cites W954714965 @default.
• W2981497166 cites W2595538957 @default.
• W2981497166 doi "https://doi.org/10.3389/fmicb.2019.02455" @default.
• W2981497166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6828654" @default.
• W2981497166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31736901" @default.
• W2981497166 hasPublicationYear "2019" @default.
• W2981497166 type Work @default.
• W2981497166 sameAs 2981497166 @default.
• W2981497166 citedByCount "19" @default.
• W2981497166 countsByYear W29814971662020 @default.
• W2981497166 countsByYear W29814971662021 @default.
• W2981497166 countsByYear W29814971662022 @default.
• W2981497166 countsByYear W29814971662023 @default.
• W2981497166 crossrefType "journal-article" @default.
• W2981497166 hasAuthorship W2981497166A5008729408 @default.
• W2981497166 hasAuthorship W2981497166A5011780300 @default.
• W2981497166 hasAuthorship W2981497166A5032213852 @default.
• W2981497166 hasAuthorship W2981497166A5035075327 @default.

• next