Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981508710> ?p ?o ?g. }
- W2981508710 endingPage "48" @default.
- W2981508710 startingPage "29" @default.
- W2981508710 abstract "Background: Cancer is a rapidly growing disease and the second most leading cause of death worldwide. Breast, colon, lung, and prostate cancer are the most diagnosed types of cancer among the majority of the population. The prevalence of these cancers is increasing rapidly due to the lack of effective drugs. The search for anti-cancer bioactive components from natural plant sources is gaining immense significance. The aim of the paper is to introduce the readers about the in vitro and in vivo biochemical mechanisms of phenolic acids and flavonoids in these four types of cancers. Methods: A literature search was carried out in databases, including Scopus, SciFinder, Springer, Science direct and Google. The main keywords used were fruits & vegetables, phenolic acids, flavonoids, anticancer, bioavailability, etc. The data obtained were integrated and analyzed. Results: The study revealed the potential molecular mechanisms of phenolic acids and flavonoids, which include the induction of apoptosis, inhibition of cell proliferation, cell-cycle arrest, induction of Poly ADP ribose polymerase cleavage, downregulation of Matrix metalloproteinases-2 and Matrix metalloproteinases-9 activities, decreased levels of B-cell lymphoma-2, etc. Promising effects of phenolic acids and flavonoids have been observed against breast, colon, lung and prostate cancers. Conclusion: The in vitro and in vivo anti-cancer mechanisms of phenolic acids and flavonoids have been revealed in this study. With the knowledge of specific molecular targets and the structural-functional relationship of bioactive compounds, the current review will open a new gateway for the scientific community and provide them a viable option to exploit more of these compounds for the development of novel and efficacious anticancer compounds." @default.
- W2981508710 created "2019-11-01" @default.
- W2981508710 creator A5022422603 @default.
- W2981508710 date "2020-04-10" @default.
- W2981508710 modified "2023-09-24" @default.
- W2981508710 title "Dietary Phenolic Acids and Flavonoids as Potential Anti-Cancer Agents: Current State of the Art and Future Perspectives" @default.
- W2981508710 cites W1240291967 @default.
- W2981508710 cites W141818632 @default.
- W2981508710 cites W1750295984 @default.
- W2981508710 cites W1757407923 @default.
- W2981508710 cites W1854826731 @default.
- W2981508710 cites W1965093545 @default.
- W2981508710 cites W1968610465 @default.
- W2981508710 cites W1969410811 @default.
- W2981508710 cites W1970593266 @default.
- W2981508710 cites W1975717755 @default.
- W2981508710 cites W1976754594 @default.
- W2981508710 cites W1979479548 @default.
- W2981508710 cites W1979659880 @default.
- W2981508710 cites W1981390981 @default.
- W2981508710 cites W1981638103 @default.
- W2981508710 cites W1981930609 @default.
- W2981508710 cites W1982058172 @default.
- W2981508710 cites W1982183760 @default.
- W2981508710 cites W1984642803 @default.
- W2981508710 cites W1985293526 @default.
- W2981508710 cites W1986072191 @default.
- W2981508710 cites W1987323108 @default.
- W2981508710 cites W1987829448 @default.
- W2981508710 cites W1988710285 @default.
- W2981508710 cites W1990293840 @default.
- W2981508710 cites W1994657003 @default.
- W2981508710 cites W1996877723 @default.
- W2981508710 cites W1997888279 @default.
- W2981508710 cites W2006826353 @default.
- W2981508710 cites W2009247506 @default.
- W2981508710 cites W2012398447 @default.
- W2981508710 cites W2014668783 @default.
- W2981508710 cites W2015641994 @default.
- W2981508710 cites W2020789999 @default.
- W2981508710 cites W2022676475 @default.
- W2981508710 cites W2028848055 @default.
- W2981508710 cites W2031134419 @default.
- W2981508710 cites W2031312741 @default.
- W2981508710 cites W2032440171 @default.
- W2981508710 cites W2036524019 @default.
- W2981508710 cites W2039339291 @default.
- W2981508710 cites W2039719057 @default.
- W2981508710 cites W2042438338 @default.
- W2981508710 cites W2043750435 @default.
- W2981508710 cites W2045631507 @default.
- W2981508710 cites W2046150786 @default.
- W2981508710 cites W2046627676 @default.
- W2981508710 cites W2051915545 @default.
- W2981508710 cites W2053713570 @default.
- W2981508710 cites W2053999060 @default.
- W2981508710 cites W2054463682 @default.
- W2981508710 cites W2057088218 @default.
- W2981508710 cites W2057805401 @default.
- W2981508710 cites W2058153177 @default.
- W2981508710 cites W2060866280 @default.
- W2981508710 cites W2062172769 @default.
- W2981508710 cites W2062780847 @default.
- W2981508710 cites W2065906773 @default.
- W2981508710 cites W2067970396 @default.
- W2981508710 cites W2068954221 @default.
- W2981508710 cites W2069547558 @default.
- W2981508710 cites W2073420121 @default.
- W2981508710 cites W2073594538 @default.
- W2981508710 cites W2074559444 @default.
- W2981508710 cites W2076734290 @default.
- W2981508710 cites W2077170523 @default.
- W2981508710 cites W2078676120 @default.
- W2981508710 cites W2084046958 @default.
- W2981508710 cites W2090102281 @default.
- W2981508710 cites W2090214784 @default.
- W2981508710 cites W2092248920 @default.
- W2981508710 cites W2093929386 @default.
- W2981508710 cites W2102634879 @default.
- W2981508710 cites W2103023937 @default.
- W2981508710 cites W2109069677 @default.
- W2981508710 cites W2111566722 @default.
- W2981508710 cites W2111686091 @default.
- W2981508710 cites W2115228774 @default.
- W2981508710 cites W2117169929 @default.
- W2981508710 cites W2120730389 @default.
- W2981508710 cites W2121448711 @default.
- W2981508710 cites W2122836175 @default.
- W2981508710 cites W2127798662 @default.
- W2981508710 cites W2130931035 @default.
- W2981508710 cites W2138218345 @default.
- W2981508710 cites W2139243915 @default.
- W2981508710 cites W2141736687 @default.
- W2981508710 cites W2142039609 @default.
- W2981508710 cites W2142279282 @default.
- W2981508710 cites W2144843569 @default.
- W2981508710 cites W2145947053 @default.
- W2981508710 cites W2149222104 @default.