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- W2981520917 abstract "Abstract We have reported antidiuretic effects of various neurotransmitters, such as noradrenaline(NA) and acetylcholine(ACh), and cyclic AMP and dibutyryl-cyclic AMP(db-cAMP) on urine outflow by microinjecting into the vasopressinergic supraoptic(SON) and paraventricular(PVN) nuclei. In this study, the effects of cyclic GMP(cGMP) and dibutyryl-cyclic GMP(db-cGMP) were investigated. The microinjections of cGMP into PVN only and of db-cGMP into both nuclei elicited dose-dependent antidiuretic effects. The median effective doses(ED50) for db-cGMP injected into SON and PVN were approx. 150 and 200 nmol, respectively. The effect of db-cGMP in SON was more potent than that of cGMP and was approx. equal to that of db-cAMP, which was almost completely blocked by the pretreatment of atropine. The effect of db-cGMP in PVN was slightly more potent than that of cGMP and less potent than that of db-cAMP, which was almost perfectly blocked by both atropine and phenoxybenzamine. A repeated microinjection of db-cGMP into these nuclei reduced the effect markedly. These results suggest that cGMP may have a role as a second messenger in the release of ACh in both nuclei and in the release of NA in PVN." @default.
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- W2981520917 date "1983-01-01" @default.
- W2981520917 modified "2023-09-23" @default.
- W2981520917 title "Antidiuretic effects of dibutyryl-cyclic GMP by micro-injecting into the supraoptic and paraventricular nuclei in the rat hypothalamus" @default.
- W2981520917 doi "https://doi.org/10.1016/s0021-5198(19)60304-5" @default.
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