Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981534711> ?p ?o ?g. }
- W2981534711 abstract "Several experimental strategies in the treatment of cancer include drug alteration of cell cycle regulatory pathways as a useful strategy. Extra-ribosomal functions of human ribosomal protein L3 (uL3) may affect DNA repair, cell cycle arrest and apoptosis. In the present study, we demonstrated that uL3 is required for the activation of G1/S transition genes. Luciferase assays established that uL3 negatively regulates the activity of E2F1 promoter. Induced ribosome-free uL3 reduces Cyclin D1 mRNA and protein levels. Using protein/protein immunoprecipitation methods, we demonstrated that uL3 physically interacts with PARP-1 affecting E2F1 transcriptional activity. Our findings led to the identification of a new pathway mediated by uL3 involving E2F1 and Cyclin D1 in the regulation of cell cycle progression." @default.
- W2981534711 created "2019-11-01" @default.
- W2981534711 creator A5039045566 @default.
- W2981534711 creator A5064694057 @default.
- W2981534711 creator A5076366848 @default.
- W2981534711 creator A5081955195 @default.
- W2981534711 date "2019-10-28" @default.
- W2981534711 modified "2023-10-15" @default.
- W2981534711 title "Ribosomal protein uL3 targets E2F1 and Cyclin D1 in cancer cell response to nucleolar stress" @default.
- W2981534711 cites W1512072225 @default.
- W2981534711 cites W1649386167 @default.
- W2981534711 cites W1834185815 @default.
- W2981534711 cites W1964081206 @default.
- W2981534711 cites W1965950662 @default.
- W2981534711 cites W1982166284 @default.
- W2981534711 cites W1982772122 @default.
- W2981534711 cites W1982989725 @default.
- W2981534711 cites W1991199800 @default.
- W2981534711 cites W1996345793 @default.
- W2981534711 cites W1999962568 @default.
- W2981534711 cites W2001600136 @default.
- W2981534711 cites W2002373110 @default.
- W2981534711 cites W2005953598 @default.
- W2981534711 cites W2009850885 @default.
- W2981534711 cites W2020251146 @default.
- W2981534711 cites W2035398180 @default.
- W2981534711 cites W2037302081 @default.
- W2981534711 cites W2059553949 @default.
- W2981534711 cites W2064761336 @default.
- W2981534711 cites W2068180488 @default.
- W2981534711 cites W2069683615 @default.
- W2981534711 cites W2077470808 @default.
- W2981534711 cites W2080213688 @default.
- W2981534711 cites W2082109120 @default.
- W2981534711 cites W2085896082 @default.
- W2981534711 cites W2090232700 @default.
- W2981534711 cites W2092972004 @default.
- W2981534711 cites W2100893053 @default.
- W2981534711 cites W2102373624 @default.
- W2981534711 cites W2106120575 @default.
- W2981534711 cites W2111518650 @default.
- W2981534711 cites W2112979110 @default.
- W2981534711 cites W2114570899 @default.
- W2981534711 cites W2128582233 @default.
- W2981534711 cites W2134041563 @default.
- W2981534711 cites W2134977493 @default.
- W2981534711 cites W2144369724 @default.
- W2981534711 cites W2150336216 @default.
- W2981534711 cites W2192367718 @default.
- W2981534711 cites W2422136427 @default.
- W2981534711 cites W2466263666 @default.
- W2981534711 cites W2472092336 @default.
- W2981534711 cites W2555667985 @default.
- W2981534711 cites W2560345512 @default.
- W2981534711 cites W2577479893 @default.
- W2981534711 cites W2583421453 @default.
- W2981534711 cites W2594655436 @default.
- W2981534711 cites W2626897616 @default.
- W2981534711 cites W2899396009 @default.
- W2981534711 cites W2906067435 @default.
- W2981534711 doi "https://doi.org/10.1038/s41598-019-51723-7" @default.
- W2981534711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6817900" @default.
- W2981534711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31659203" @default.
- W2981534711 hasPublicationYear "2019" @default.
- W2981534711 type Work @default.
- W2981534711 sameAs 2981534711 @default.
- W2981534711 citedByCount "23" @default.
- W2981534711 countsByYear W29815347112020 @default.
- W2981534711 countsByYear W29815347112021 @default.
- W2981534711 countsByYear W29815347112022 @default.
- W2981534711 countsByYear W29815347112023 @default.
- W2981534711 crossrefType "journal-article" @default.
- W2981534711 hasAuthorship W2981534711A5039045566 @default.
- W2981534711 hasAuthorship W2981534711A5064694057 @default.
- W2981534711 hasAuthorship W2981534711A5076366848 @default.
- W2981534711 hasAuthorship W2981534711A5081955195 @default.
- W2981534711 hasBestOaLocation W29815347111 @default.
- W2981534711 hasConcept C104317684 @default.
- W2981534711 hasConcept C1491633281 @default.
- W2981534711 hasConcept C183022183 @default.
- W2981534711 hasConcept C199835354 @default.
- W2981534711 hasConcept C29537977 @default.
- W2981534711 hasConcept C38062823 @default.
- W2981534711 hasConcept C54355233 @default.
- W2981534711 hasConcept C67705224 @default.
- W2981534711 hasConcept C86803240 @default.
- W2981534711 hasConcept C88478588 @default.
- W2981534711 hasConcept C95444343 @default.
- W2981534711 hasConceptScore W2981534711C104317684 @default.
- W2981534711 hasConceptScore W2981534711C1491633281 @default.
- W2981534711 hasConceptScore W2981534711C183022183 @default.
- W2981534711 hasConceptScore W2981534711C199835354 @default.
- W2981534711 hasConceptScore W2981534711C29537977 @default.
- W2981534711 hasConceptScore W2981534711C38062823 @default.
- W2981534711 hasConceptScore W2981534711C54355233 @default.
- W2981534711 hasConceptScore W2981534711C67705224 @default.
- W2981534711 hasConceptScore W2981534711C86803240 @default.
- W2981534711 hasConceptScore W2981534711C88478588 @default.
- W2981534711 hasConceptScore W2981534711C95444343 @default.
- W2981534711 hasFunder F4320322218 @default.