FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981535609> ?p ?o ?g. }

• W2981535609 endingPage "1539" @default.
• W2981535609 startingPage "1523" @default.
• W2981535609 abstract "Lycium barbarum polysaccharides (LBP) are the major ingredients of wolfberry. In this study, we investigated the role of LBP in endothelial dysfunction induced by oxidative stress and the underlying mechanisms using thoracic aortic endothelial cells of rat (RAECs) as a model. We found that Ang II inhibits cell viability of RAECs with 10[Formula: see text][Formula: see text]mol/L of Ang II treatment for 24[Formula: see text]h most potential ([Formula: see text]), the level of reactive oxygen species (ROS) is increased by Ang II treatment ([Formula: see text]), and the expression of Occludin and Zonula occludens-1 (ZO-1) is decreased by Ang II treatment ([Formula: see text]). However, preincubation of cells with LBP could inhibit the changes caused by Ang II, LBP increased cell viability ([Formula: see text]), decreased the level of ROS ([Formula: see text]), and up-regulated the expression of Occludin ([Formula: see text]) and ZO-1. In addition, Ang II treatment increased the expression of EGFR and p-EGFR (Try1172) and which can be inhibited by LBP. On the contrary, expression of ErbB2, p-ErbB2 (Try1248), PI 3 K, p-e-NOS (Ser1177) ([Formula: see text]), and p-AKT (Ser473) ([Formula: see text]) was inhibited by Ang II treatment and which can be increased by LBP. Treatment of the cells with inhibitors showed that the regulation of p-e-NOS and p-AKT expression by Ang II and LBP can be blocked by PI 3 K inhibitor wortmannin but not EGFR and ErbB2 inhibitor AC480. Taken together, our results suggested that LBP plays a critical role in maintaining the integrality of blood vessel endothelium through reduced production of ROS via regulating the activity of EGFR, ErbB2, PI 3 K/AKT/e-NOS, and which may offer a novel therapeutic option in the management of endothelial dysfunction." @default.
• W2981535609 created "2019-11-01" @default.
• W2981535609 creator A5003292761 @default.
• W2981535609 creator A5015522949 @default.
• W2981535609 creator A5025632368 @default.
• W2981535609 creator A5057749483 @default.
• W2981535609 creator A5078511332 @default.
• W2981535609 creator A5085500621 @default.
• W2981535609 date "2019-01-01" @default.
• W2981535609 modified "2023-09-25" @default.
• W2981535609 title "Role of EGFR/ErbB2 and PI₃K/AKT/e-NOS in<i>Lycium barbarum polysaccharides</i>Ameliorating Endothelial Dysfunction Induced by Oxidative Stress" @default.
• W2981535609 cites W1528794535 @default.
• W2981535609 cites W1939691077 @default.
• W2981535609 cites W1953928363 @default.
• W2981535609 cites W1972377404 @default.
• W2981535609 cites W1975927635 @default.
• W2981535609 cites W1981944533 @default.
• W2981535609 cites W1986564239 @default.
• W2981535609 cites W1994491528 @default.
• W2981535609 cites W2020517552 @default.
• W2981535609 cites W2026268138 @default.
• W2981535609 cites W2038648163 @default.
• W2981535609 cites W2048368531 @default.
• W2981535609 cites W2052302181 @default.
• W2981535609 cites W2066860513 @default.
• W2981535609 cites W2069377326 @default.
• W2981535609 cites W2070727232 @default.
• W2981535609 cites W2078874666 @default.
• W2981535609 cites W2096595244 @default.
• W2981535609 cites W2111788605 @default.
• W2981535609 cites W2118731533 @default.
• W2981535609 cites W2119043221 @default.
• W2981535609 cites W2126791179 @default.
• W2981535609 cites W2136433300 @default.
• W2981535609 cites W2239728421 @default.
• W2981535609 cites W2290282425 @default.
• W2981535609 cites W2330210822 @default.
• W2981535609 cites W2337369609 @default.
• W2981535609 cites W2344233709 @default.
• W2981535609 cites W2564380693 @default.
• W2981535609 cites W2620861083 @default.
• W2981535609 cites W2736132555 @default.
• W2981535609 cites W2760047982 @default.
• W2981535609 cites W2791620985 @default.
• W2981535609 cites W2801789151 @default.
• W2981535609 cites W2802062281 @default.
• W2981535609 cites W2884516608 @default.
• W2981535609 cites W2885664758 @default.
• W2981535609 cites W2886290354 @default.
• W2981535609 cites W2891781570 @default.
• W2981535609 cites W2896929099 @default.
• W2981535609 cites W2899144263 @default.
• W2981535609 cites W2900933295 @default.
• W2981535609 cites W2902495274 @default.
• W2981535609 doi "https://doi.org/10.1142/s0192415x19500782" @default.
• W2981535609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31645123" @default.
• W2981535609 hasPublicationYear "2019" @default.
• W2981535609 type Work @default.
• W2981535609 sameAs 2981535609 @default.
• W2981535609 citedByCount "12" @default.
• W2981535609 countsByYear W29815356092020 @default.
• W2981535609 countsByYear W29815356092021 @default.
• W2981535609 countsByYear W29815356092022 @default.
• W2981535609 countsByYear W29815356092023 @default.
• W2981535609 crossrefType "journal-article" @default.
• W2981535609 hasAuthorship W2981535609A5003292761 @default.
• W2981535609 hasAuthorship W2981535609A5015522949 @default.
• W2981535609 hasAuthorship W2981535609A5025632368 @default.
• W2981535609 hasAuthorship W2981535609A5057749483 @default.
• W2981535609 hasAuthorship W2981535609A5078511332 @default.
• W2981535609 hasAuthorship W2981535609A5085500621 @default.
• W2981535609 hasConcept C126322002 @default.
• W2981535609 hasConcept C134018914 @default.
• W2981535609 hasConcept C1491633281 @default.
• W2981535609 hasConcept C153911025 @default.
• W2981535609 hasConcept C177779419 @default.
• W2981535609 hasConcept C185592680 @default.
• W2981535609 hasConcept C2775962179 @default.
• W2981535609 hasConcept C2776151105 @default.
• W2981535609 hasConcept C2780972559 @default.
• W2981535609 hasConcept C48349386 @default.
• W2981535609 hasConcept C53227056 @default.
• W2981535609 hasConcept C55493867 @default.
• W2981535609 hasConcept C62478195 @default.
• W2981535609 hasConcept C71924100 @default.
• W2981535609 hasConcept C75217442 @default.
• W2981535609 hasConcept C86803240 @default.
• W2981535609 hasConcept C98274493 @default.
• W2981535609 hasConceptScore W2981535609C126322002 @default.
• W2981535609 hasConceptScore W2981535609C134018914 @default.
• W2981535609 hasConceptScore W2981535609C1491633281 @default.
• W2981535609 hasConceptScore W2981535609C153911025 @default.
• W2981535609 hasConceptScore W2981535609C177779419 @default.
• W2981535609 hasConceptScore W2981535609C185592680 @default.
• W2981535609 hasConceptScore W2981535609C2775962179 @default.
• W2981535609 hasConceptScore W2981535609C2776151105 @default.
• W2981535609 hasConceptScore W2981535609C2780972559 @default.
• W2981535609 hasConceptScore W2981535609C48349386 @default.

• next