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- W2981569223 startingPage "37" @default.
- W2981569223 abstract "Efficient mechanisms of central tolerance, including receptor editing and deletion, prevent highly self-reactive B cell receptors (BCRs) from populating the periphery. Despite this, modest self-reactivity persists in (and may even be actively selected into) the mature B cell repertoire. In this review, we discuss new insights into mechanisms of peripheral B cell tolerance that restrain mature B cells from mounting inappropriate responses to endogenous antigens, and place recent work into historical context. In particular, we discuss new findings that have arisen from application of a novel in vivo reporter of BCR signaling, Nur77-eGFP, expression of which scales with the degree of self-reactivity in both monoclonal and polyclonal B cell repertoires. We discuss new and historical evidence that self-reactivity is not just tolerated, but actively selected into the peripheral repertoire. We review recent progress in understanding how dual expression of the IgM and IgD BCR isotypes on mature naive follicular B cells tunes responsiveness to endogenous antigen recognition, and discuss how this may be integrated with other features of clonal anergy. Finally, we discuss how expression of Nur77 itself couples chronic antigen stimulation with B cell tolerance." @default.
- W2981569223 created "2019-11-01" @default.
- W2981569223 creator A5023603694 @default.
- W2981569223 creator A5039726987 @default.
- W2981569223 creator A5049550450 @default.
- W2981569223 creator A5057532755 @default.
- W2981569223 date "2019-10-20" @default.
- W2981569223 modified "2023-10-08" @default.
- W2981569223 title "Self‐reactivity on a spectrum: A sliding scale of peripheral B cell tolerance" @default.
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