Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981569509> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2981569509 abstract "Abstract Purpose Due to bioanalytical limitations it was previously not possible to evaluate the pharmacokinetics of dabigatran etexilate. We have developed validated methods to assay dabigatran etexilate, unconjugated dabigatran, and total dabigatran that will allow for a complete investigation into the pharmacokinetics of dabigatran etexilate mesylate. This study was designed to evaluate the pharmacokinetics of these analytes in healthy subjects. Methods This was an open-label, single-dose, one-period, one-treatment study. A single oral dose of dabigatran etexilate mesylate capsule containing the equivalent of 150 mg dabigatran etexilate was administered to each subject. A total of 23 blood samples for pharmacokinetic analysis were collected and analyzed from each subject. Safety and tolerability were monitored throughout the study. Results Eighteen healthy subjects were enrolled, dosed, and completed the study. The dabigatran etexilate mean Cmax was 6.9±5.63 ng/mL, the median Tmax was 0.67 h (range=0.50–1.00 h), the mean AUCt was 5.32±4.82 ng/mL·h, the mean AUCinf was 5.36±4.83 pg/mL*h, and the mean t1/2 was 0.54±0.26 h. Only one subject experienced an adverse event. Conclusion Using validated bioanalytical methods, a complete characterization of dabigatran etexilate, total dabigatran, and unconjugated dabigatran pharmacokinetics was achieved. Advancements in the development of new more accurate, specific, and sensitive validated bioanalytical methods such as these enable for a complete understanding of the drug’s pharmacokinetics and this, in turn, can have an impact on both the drug development and the evaluation of generic formulations." @default.
- W2981569509 created "2019-11-01" @default.
- W2981569509 creator A5070840983 @default.
- W2981569509 creator A5082379395 @default.
- W2981569509 date "2019-10-25" @default.
- W2981569509 modified "2023-10-18" @default.
- W2981569509 title "A Pharmacokinetic Evaluation of Dabigatran Etexilate, Total Dabigatran, and Unconjugated Dabigatran Following the Administration of Dabigatran Etexilate Mesylate Capsules in Healthy Male and Female Subjects" @default.
- W2981569509 cites W1482291463 @default.
- W2981569509 cites W1547546593 @default.
- W2981569509 cites W1977402010 @default.
- W2981569509 cites W2014682667 @default.
- W2981569509 cites W2064012881 @default.
- W2981569509 cites W2066327183 @default.
- W2981569509 cites W2073546757 @default.
- W2981569509 cites W2121394112 @default.
- W2981569509 cites W2158014557 @default.
- W2981569509 cites W2168403443 @default.
- W2981569509 cites W2225937646 @default.
- W2981569509 cites W2342049659 @default.
- W2981569509 cites W2509795914 @default.
- W2981569509 cites W2528969682 @default.
- W2981569509 cites W3004050106 @default.
- W2981569509 doi "https://doi.org/10.1055/a-1025-0119" @default.
- W2981569509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31652461" @default.
- W2981569509 hasPublicationYear "2019" @default.
- W2981569509 type Work @default.
- W2981569509 sameAs 2981569509 @default.
- W2981569509 citedByCount "2" @default.
- W2981569509 countsByYear W29815695092021 @default.
- W2981569509 crossrefType "journal-article" @default.
- W2981569509 hasAuthorship W2981569509A5070840983 @default.
- W2981569509 hasAuthorship W2981569509A5082379395 @default.
- W2981569509 hasConcept C112705442 @default.
- W2981569509 hasConcept C126322002 @default.
- W2981569509 hasConcept C178790620 @default.
- W2981569509 hasConcept C185592680 @default.
- W2981569509 hasConcept C22979827 @default.
- W2981569509 hasConcept C2776301958 @default.
- W2981569509 hasConcept C2777288759 @default.
- W2981569509 hasConcept C2778810321 @default.
- W2981569509 hasConcept C2779161974 @default.
- W2981569509 hasConcept C2780194963 @default.
- W2981569509 hasConcept C42219234 @default.
- W2981569509 hasConcept C42404028 @default.
- W2981569509 hasConcept C71924100 @default.
- W2981569509 hasConcept C98274493 @default.
- W2981569509 hasConceptScore W2981569509C112705442 @default.
- W2981569509 hasConceptScore W2981569509C126322002 @default.
- W2981569509 hasConceptScore W2981569509C178790620 @default.
- W2981569509 hasConceptScore W2981569509C185592680 @default.
- W2981569509 hasConceptScore W2981569509C22979827 @default.
- W2981569509 hasConceptScore W2981569509C2776301958 @default.
- W2981569509 hasConceptScore W2981569509C2777288759 @default.
- W2981569509 hasConceptScore W2981569509C2778810321 @default.
- W2981569509 hasConceptScore W2981569509C2779161974 @default.
- W2981569509 hasConceptScore W2981569509C2780194963 @default.
- W2981569509 hasConceptScore W2981569509C42219234 @default.
- W2981569509 hasConceptScore W2981569509C42404028 @default.
- W2981569509 hasConceptScore W2981569509C71924100 @default.
- W2981569509 hasConceptScore W2981569509C98274493 @default.
- W2981569509 hasLocation W29815695091 @default.
- W2981569509 hasLocation W29815695092 @default.
- W2981569509 hasOpenAccess W2981569509 @default.
- W2981569509 hasPrimaryLocation W29815695091 @default.
- W2981569509 hasRelatedWork W1991854939 @default.
- W2981569509 hasRelatedWork W2018313535 @default.
- W2981569509 hasRelatedWork W2104641112 @default.
- W2981569509 hasRelatedWork W2354680669 @default.
- W2981569509 hasRelatedWork W2359939078 @default.
- W2981569509 hasRelatedWork W2365455541 @default.
- W2981569509 hasRelatedWork W2411695865 @default.
- W2981569509 hasRelatedWork W2462293959 @default.
- W2981569509 hasRelatedWork W3089081291 @default.
- W2981569509 hasRelatedWork W4284882878 @default.
- W2981569509 isParatext "false" @default.
- W2981569509 isRetracted "false" @default.
- W2981569509 magId "2981569509" @default.
- W2981569509 workType "article" @default.