Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981604168> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2981604168 endingPage "23" @default.
- W2981604168 startingPage "11" @default.
- W2981604168 abstract "The present study was designed to evaluate the fertility potential of Ayurvedic proprietary medicine ‘progen’—a herbo-mineral formulation—in experimental rats. A total of 24 male wistar rats were rendered infertile by administration of tetracycline (22.5 mg/kg p.o) and restraining stress (2 h a day) for 7 weeks. At the end of 7th week, six animals were sacrificed. Blood serum was analysed for triglyceride (TG), total cholesterol (T-CHO), follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone. Epididymal semen was examined for sperm count, %motility and %viability. Testes were dissected out and anti-oxidant as well as histopathological studies were performed. The results obtained showed chronic abnormalities in sperm parameters, serum hormonal level, antioxidant profile, and histopathology in untreated infertile rats when compared with normal control rats which confirmed successful induction of infertility. Infertile rats were further divided into three groups (six rats in each) and treated with progen 45 mg/kg and 90 mg/kg as well as Clomifene Citrate 2.5 mg/kg for 4 weeks in continuation with tetracycline and restraining stress. At the end of 11th week, all the animals were sacrificed and analysed for various parameters mentioned above. Treatment with progen at the dose of 45 mg/kg and 90 mg/kg showed significant (p<0.0001) dose-dependent improvement in sperm parameters, serum hormonal level, anti-oxidant profile as well as significant (p<0.0001) decrease in elevated fasting blood glucose level (BGL) and TG level when compared with untreated infertile control rats. Histopathological studies showed normal architecture of testis. It was concluded that progen—herbo-mineral formulation—exhibits significant potential to revert chronic male infertility which can be attributed to the various phytochemical constituents present in it. However, further study is required to establish its exact mechanism of action and responsible phytoconstituents. Keywords: “ Progen” formulation, tetracycline, restraining stress, male infertility Cite this Article Khatib NA, Barve SS, Patil SM et al . “Progen” Herbo-Mineral Formulation Modulates Spermatogenesis in Experimentally Induced Infertile Rats. Research & Reviews: A Journal of Pharmacology . 2016; 6(3): 11–23p." @default.
- W2981604168 created "2019-11-01" @default.
- W2981604168 creator A5042102227 @default.
- W2981604168 creator A5051151481 @default.
- W2981604168 creator A5054344285 @default.
- W2981604168 creator A5060931868 @default.
- W2981604168 date "2016-12-08" @default.
- W2981604168 modified "2023-09-27" @default.
- W2981604168 title "“Progen†Herbo-Mineral Formulation Modulates Spermatogenesis in Experimentally Induced Infertile Rats" @default.
- W2981604168 hasPublicationYear "2016" @default.
- W2981604168 type Work @default.
- W2981604168 sameAs 2981604168 @default.
- W2981604168 citedByCount "0" @default.
- W2981604168 crossrefType "journal-article" @default.
- W2981604168 hasAuthorship W2981604168A5042102227 @default.
- W2981604168 hasAuthorship W2981604168A5051151481 @default.
- W2981604168 hasAuthorship W2981604168A5054344285 @default.
- W2981604168 hasAuthorship W2981604168A5060931868 @default.
- W2981604168 hasConcept C123765429 @default.
- W2981604168 hasConcept C126322002 @default.
- W2981604168 hasConcept C134018914 @default.
- W2981604168 hasConcept C142724271 @default.
- W2981604168 hasConcept C16685009 @default.
- W2981604168 hasConcept C2777338322 @default.
- W2981604168 hasConcept C2777688143 @default.
- W2981604168 hasConcept C2778093475 @default.
- W2981604168 hasConcept C2778575703 @default.
- W2981604168 hasConcept C2779234561 @default.
- W2981604168 hasConcept C2779279165 @default.
- W2981604168 hasConcept C2779279991 @default.
- W2981604168 hasConcept C2781087480 @default.
- W2981604168 hasConcept C54355233 @default.
- W2981604168 hasConcept C544855455 @default.
- W2981604168 hasConcept C71315377 @default.
- W2981604168 hasConcept C71924100 @default.
- W2981604168 hasConcept C86803240 @default.
- W2981604168 hasConceptScore W2981604168C123765429 @default.
- W2981604168 hasConceptScore W2981604168C126322002 @default.
- W2981604168 hasConceptScore W2981604168C134018914 @default.
- W2981604168 hasConceptScore W2981604168C142724271 @default.
- W2981604168 hasConceptScore W2981604168C16685009 @default.
- W2981604168 hasConceptScore W2981604168C2777338322 @default.
- W2981604168 hasConceptScore W2981604168C2777688143 @default.
- W2981604168 hasConceptScore W2981604168C2778093475 @default.
- W2981604168 hasConceptScore W2981604168C2778575703 @default.
- W2981604168 hasConceptScore W2981604168C2779234561 @default.
- W2981604168 hasConceptScore W2981604168C2779279165 @default.
- W2981604168 hasConceptScore W2981604168C2779279991 @default.
- W2981604168 hasConceptScore W2981604168C2781087480 @default.
- W2981604168 hasConceptScore W2981604168C54355233 @default.
- W2981604168 hasConceptScore W2981604168C544855455 @default.
- W2981604168 hasConceptScore W2981604168C71315377 @default.
- W2981604168 hasConceptScore W2981604168C71924100 @default.
- W2981604168 hasConceptScore W2981604168C86803240 @default.
- W2981604168 hasIssue "3" @default.
- W2981604168 hasLocation W29816041681 @default.
- W2981604168 hasOpenAccess W2981604168 @default.
- W2981604168 hasPrimaryLocation W29816041681 @default.
- W2981604168 hasRelatedWork W2033628935 @default.
- W2981604168 hasRelatedWork W2309904952 @default.
- W2981604168 hasRelatedWork W2324457628 @default.
- W2981604168 hasRelatedWork W2553759616 @default.
- W2981604168 hasRelatedWork W2769665411 @default.
- W2981604168 hasRelatedWork W2886608768 @default.
- W2981604168 hasRelatedWork W2887022574 @default.
- W2981604168 hasRelatedWork W2899040706 @default.
- W2981604168 hasRelatedWork W2899335212 @default.
- W2981604168 hasRelatedWork W2942516818 @default.
- W2981604168 hasRelatedWork W2964000197 @default.
- W2981604168 hasRelatedWork W2969134901 @default.
- W2981604168 hasRelatedWork W2992443698 @default.
- W2981604168 hasRelatedWork W3026382780 @default.
- W2981604168 hasRelatedWork W3027406603 @default.
- W2981604168 hasRelatedWork W3032548933 @default.
- W2981604168 hasRelatedWork W3038009946 @default.
- W2981604168 hasRelatedWork W3088313345 @default.
- W2981604168 hasRelatedWork W2184656842 @default.
- W2981604168 hasRelatedWork W2587198067 @default.
- W2981604168 hasVolume "6" @default.
- W2981604168 isParatext "false" @default.
- W2981604168 isRetracted "false" @default.
- W2981604168 magId "2981604168" @default.
- W2981604168 workType "article" @default.