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• W2981620099 abstract "Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization furnished a small molecule chemical probe (SGC-AAK1-1, 25) that is potent and selective for AAK1/BMP2K over other NAK family members, demonstrates narrow activity in a kinome-wide screen, and is functionally active in cells. This inhibitor represents one of the best available small molecule tools to study the functions of AAK1 and BMP2K." @default.
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• W2981620099 date "2019-10-23" @default.
• W2981620099 modified "2023-10-18" @default.
• W2981620099 title "SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K" @default.
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• W2981620099 doi "https://doi.org/10.1021/acsmedchemlett.9b00399" @default.
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