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- W2981631051 abstract "Maintaining blood glucose levels through periods of fasting or excess of nutrients is a crucial function to the survival of the organism. In this review, we describe the glucose metabolism during the fed-to-fasted transition and in two metabolic diseases characterized by either an overproduction of glucose and hyperglycemia, that is, type 2 diabetes, or by a deficiency of glucose production and hypoglycemia, that is, glycogen storage disease type I. In these two pathologies, glucose-6 phosphate plays a master role in cell signaling. Indeed, the increased flux downstream of glucose-6 phosphate leads to a complete metabolism reprograming and an accumulation of lipids in the liver and kidneys. Thus, with time, type 2 diabetic patients and GSDI patients can develop hepatic tumors and chronic kidney disease." @default.
- W2981631051 created "2019-11-01" @default.
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- W2981631051 date "2019-01-01" @default.
- W2981631051 modified "2023-09-26" @default.
- W2981631051 title "Master role of glucose-6-phosphate in cell signaling and consequences of its deregulation in the liver and kidneys" @default.
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- W2981631051 doi "https://doi.org/10.1016/b978-0-12-849886-6.00021-5" @default.
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