FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981652403> ?p ?o ?g. }

• W2981652403 endingPage "112" @default.
• W2981652403 startingPage "105" @default.
• W2981652403 abstract "Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV), has ranked among the major economically significant pathogen in the global swine industry. The PRRSV nonstructural protein (nsp)11 possesses nidovirus endoribonuclease (NendoU) activity, which is important for virus replication and suppression of the host innate immunity system. Recent proteomic study found that TRIM59 (tripartite motif-containing 59) interacted with the nsp11, albeit the exact role it plays in PRRSV infection remains enigmatic. Herein, we first confirmed the interaction between nsp11 and TRIM59 in co-transfected HEK293T cells and PRRSV-infected pulmonary alveolar macrophages (PAMs). The interacting domains between TRIM59 and nsp11 were further determined to be the N-terminal RING domain in TRIM59 and the C-terminal NendoU domain in nsp11, respectively. Moreover, we reported that overexpression of TRIM59 inhibited PRRSV infection in Marc-145 cells. Conversely, small interfering RNA (siRNA) depletion of TRIM59 resulted in enhanced production of PRRSV in PAMs. Together, these data add TRIM59 as a crucial antiviral component against PRRSV and provide new insights for development of new compounds to reduce PRRSV infection." @default.
• W2981652403 created "2019-11-01" @default.
• W2981652403 creator A5003421082 @default.
• W2981652403 creator A5007564557 @default.
• W2981652403 creator A5010831436 @default.
• W2981652403 creator A5016991460 @default.
• W2981652403 creator A5030631404 @default.
• W2981652403 creator A5032791091 @default.
• W2981652403 creator A5044179463 @default.
• W2981652403 creator A5046454314 @default.
• W2981652403 creator A5056919239 @default.
• W2981652403 creator A5064842058 @default.
• W2981652403 creator A5083872248 @default.
• W2981652403 creator A5086664284 @default.
• W2981652403 date "2019-12-01" @default.
• W2981652403 modified "2023-09-23" @default.
• W2981652403 title "TRIM59 inhibits porcine reproductive and respiratory syndrome virus (PRRSV)-2 replication in vitro" @default.
• W2981652403 cites W1584324401 @default.
• W2981652403 cites W1816491710 @default.
• W2981652403 cites W1852542211 @default.
• W2981652403 cites W2000543657 @default.
• W2981652403 cites W2003043056 @default.
• W2981652403 cites W2005578366 @default.
• W2981652403 cites W2009691717 @default.
• W2981652403 cites W2023957303 @default.
• W2981652403 cites W2034283391 @default.
• W2981652403 cites W2059565374 @default.
• W2981652403 cites W2060613269 @default.
• W2981652403 cites W2064787487 @default.
• W2981652403 cites W2066830254 @default.
• W2981652403 cites W2071711205 @default.
• W2981652403 cites W2078288243 @default.
• W2981652403 cites W2078966431 @default.
• W2981652403 cites W2083897424 @default.
• W2981652403 cites W2093606554 @default.
• W2981652403 cites W2100867908 @default.
• W2981652403 cites W2101479766 @default.
• W2981652403 cites W2106198457 @default.
• W2981652403 cites W2117365587 @default.
• W2981652403 cites W2123014574 @default.
• W2981652403 cites W2130964657 @default.
• W2981652403 cites W2133109371 @default.
• W2981652403 cites W2140550112 @default.
• W2981652403 cites W2144147369 @default.
• W2981652403 cites W2175546290 @default.
• W2981652403 cites W2272141132 @default.
• W2981652403 cites W2319482732 @default.
• W2981652403 cites W2341584572 @default.
• W2981652403 cites W2343317163 @default.
• W2981652403 cites W2418098855 @default.
• W2981652403 cites W2515729157 @default.
• W2981652403 cites W2529732762 @default.
• W2981652403 cites W2533804187 @default.
• W2981652403 cites W2553075449 @default.
• W2981652403 cites W2563185540 @default.
• W2981652403 cites W2565619044 @default.
• W2981652403 cites W2573216293 @default.
• W2981652403 cites W2588090893 @default.
• W2981652403 cites W2591967114 @default.
• W2981652403 cites W2593276833 @default.
• W2981652403 cites W2609505966 @default.
• W2981652403 cites W2617820337 @default.
• W2981652403 cites W2627077408 @default.
• W2981652403 cites W2662089374 @default.
• W2981652403 cites W2735866512 @default.
• W2981652403 cites W2736391469 @default.
• W2981652403 cites W2744157367 @default.
• W2981652403 cites W2746888732 @default.
• W2981652403 cites W2747560763 @default.
• W2981652403 cites W2765519486 @default.
• W2981652403 cites W2766984153 @default.
• W2981652403 cites W2787928770 @default.
• W2981652403 cites W2793297246 @default.
• W2981652403 cites W2798222701 @default.
• W2981652403 cites W2886895392 @default.
• W2981652403 cites W2891682036 @default.
• W2981652403 cites W2897490185 @default.
• W2981652403 cites W2955578920 @default.
• W2981652403 cites W2955951159 @default.
• W2981652403 cites W2970135200 @default.
• W2981652403 cites W4210718823 @default.
• W2981652403 doi "https://doi.org/10.1016/j.rvsc.2019.10.004" @default.
• W2981652403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31683196" @default.
• W2981652403 hasPublicationYear "2019" @default.
• W2981652403 type Work @default.
• W2981652403 sameAs 2981652403 @default.
• W2981652403 citedByCount "11" @default.
• W2981652403 countsByYear W29816524032020 @default.
• W2981652403 countsByYear W29816524032021 @default.
• W2981652403 countsByYear W29816524032022 @default.
• W2981652403 countsByYear W29816524032023 @default.
• W2981652403 crossrefType "journal-article" @default.
• W2981652403 hasAuthorship W2981652403A5003421082 @default.
• W2981652403 hasAuthorship W2981652403A5007564557 @default.
• W2981652403 hasAuthorship W2981652403A5010831436 @default.
• W2981652403 hasAuthorship W2981652403A5016991460 @default.
• W2981652403 hasAuthorship W2981652403A5030631404 @default.
• W2981652403 hasAuthorship W2981652403A5032791091 @default.

• next