FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981658097> ?p ?o ?g. }

• W2981658097 endingPage "116877" @default.
• W2981658097 startingPage "116877" @default.
• W2981658097 abstract "AMP-activated protein kinase (AMPK) is induced by the exhaustion of cellular energy and activates adaptive alterations in cellular metabolism, which is the basis for cell survival during different environmental stresses. We aimed to investigate the biological functions of AMPK and its molecular mechanism in regulating thyroid cancer (TC) progression. In current study, we found that activation of AMPK by multiple agonists suppresses TC cell proliferation. However, AMPK activation also led to TC cell migration at the same time. Depletion of AMPK abolished the effect of its agonist on cell multiplication and migration. Mechanistic investigations revealed that the impact of AMPK in terms of cell migration is dependent on its nuclear translocation, since site mutation of AMPK in its nuclear translocation domain (K244A) abolished TC cell migration but did not affect the inhibition of cell proliferation by AMPK agonist. Moreover, the nuclear AMPK recruits PKM2 and β-catenin by their interaction, which promotes the transcription of cell migration related genes, including MMP7 and c-Myc. Furthermore, depletion of PKM2/β-catenin abolished the migration effect of AMPK agonists, but did not affect their effects on suppression of cell proliferation. Our results provided a novel function of AMPK in cancer migration, and suggested that a combination of AMPK activation and PKM2 depletion or inhibition can be a new strategy to achieve better therapeutic effects for TC patients." @default.
• W2981658097 created "2019-11-01" @default.
• W2981658097 creator A5005673886 @default.
• W2981658097 creator A5026548744 @default.
• W2981658097 creator A5031523730 @default.
• W2981658097 creator A5041498647 @default.
• W2981658097 creator A5046876998 @default.
• W2981658097 creator A5051497305 @default.
• W2981658097 creator A5069842224 @default.
• W2981658097 creator A5082857859 @default.
• W2981658097 date "2019-12-01" @default.
• W2981658097 modified "2023-10-12" @default.
• W2981658097 title "Activation of AMPK promotes thyroid cancer cell migration through its interaction with PKM2 and β-catenin" @default.
• W2981658097 cites W1832714398 @default.
• W2981658097 cites W1969836970 @default.
• W2981658097 cites W1970205234 @default.
• W2981658097 cites W1979656912 @default.
• W2981658097 cites W1982085282 @default.
• W2981658097 cites W2014409691 @default.
• W2981658097 cites W2015207840 @default.
• W2981658097 cites W2023947368 @default.
• W2981658097 cites W2028897202 @default.
• W2981658097 cites W2063018637 @default.
• W2981658097 cites W2084403048 @default.
• W2981658097 cites W2089630167 @default.
• W2981658097 cites W2095939924 @default.
• W2981658097 cites W2101774229 @default.
• W2981658097 cites W2103692341 @default.
• W2981658097 cites W2106204137 @default.
• W2981658097 cites W2110103733 @default.
• W2981658097 cites W2114825009 @default.
• W2981658097 cites W2124231104 @default.
• W2981658097 cites W2135504542 @default.
• W2981658097 cites W2140162236 @default.
• W2981658097 cites W2146654374 @default.
• W2981658097 cites W2155598285 @default.
• W2981658097 cites W2165189414 @default.
• W2981658097 cites W2166503791 @default.
• W2981658097 cites W2170552969 @default.
• W2981658097 cites W2246558836 @default.
• W2981658097 cites W2789258958 @default.
• W2981658097 cites W2790354851 @default.
• W2981658097 cites W2791998267 @default.
• W2981658097 cites W2910899834 @default.
• W2981658097 doi "https://doi.org/10.1016/j.lfs.2019.116877" @default.
• W2981658097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31669575" @default.
• W2981658097 hasPublicationYear "2019" @default.
• W2981658097 type Work @default.
• W2981658097 sameAs 2981658097 @default.
• W2981658097 citedByCount "8" @default.
• W2981658097 countsByYear W29816580972020 @default.
• W2981658097 countsByYear W29816580972021 @default.
• W2981658097 countsByYear W29816580972022 @default.
• W2981658097 countsByYear W29816580972023 @default.
• W2981658097 crossrefType "journal-article" @default.
• W2981658097 hasAuthorship W2981658097A5005673886 @default.
• W2981658097 hasAuthorship W2981658097A5026548744 @default.
• W2981658097 hasAuthorship W2981658097A5031523730 @default.
• W2981658097 hasAuthorship W2981658097A5041498647 @default.
• W2981658097 hasAuthorship W2981658097A5046876998 @default.
• W2981658097 hasAuthorship W2981658097A5051497305 @default.
• W2981658097 hasAuthorship W2981658097A5069842224 @default.
• W2981658097 hasAuthorship W2981658097A5082857859 @default.
• W2981658097 hasConcept C10730799 @default.
• W2981658097 hasConcept C11960822 @default.
• W2981658097 hasConcept C137738243 @default.
• W2981658097 hasConcept C1491633281 @default.
• W2981658097 hasConcept C185592680 @default.
• W2981658097 hasConcept C20251656 @default.
• W2981658097 hasConcept C2780124434 @default.
• W2981658097 hasConcept C2780854706 @default.
• W2981658097 hasConcept C502942594 @default.
• W2981658097 hasConcept C55493867 @default.
• W2981658097 hasConcept C62112901 @default.
• W2981658097 hasConcept C62231903 @default.
• W2981658097 hasConcept C86803240 @default.
• W2981658097 hasConcept C95444343 @default.
• W2981658097 hasConcept C97029542 @default.
• W2981658097 hasConceptScore W2981658097C10730799 @default.
• W2981658097 hasConceptScore W2981658097C11960822 @default.
• W2981658097 hasConceptScore W2981658097C137738243 @default.
• W2981658097 hasConceptScore W2981658097C1491633281 @default.
• W2981658097 hasConceptScore W2981658097C185592680 @default.
• W2981658097 hasConceptScore W2981658097C20251656 @default.
• W2981658097 hasConceptScore W2981658097C2780124434 @default.
• W2981658097 hasConceptScore W2981658097C2780854706 @default.
• W2981658097 hasConceptScore W2981658097C502942594 @default.
• W2981658097 hasConceptScore W2981658097C55493867 @default.
• W2981658097 hasConceptScore W2981658097C62112901 @default.
• W2981658097 hasConceptScore W2981658097C62231903 @default.
• W2981658097 hasConceptScore W2981658097C86803240 @default.
• W2981658097 hasConceptScore W2981658097C95444343 @default.
• W2981658097 hasConceptScore W2981658097C97029542 @default.
• W2981658097 hasFunder F4320335777 @default.
• W2981658097 hasLocation W29816580971 @default.
• W2981658097 hasLocation W29816580972 @default.
• W2981658097 hasOpenAccess W2981658097 @default.
• W2981658097 hasPrimaryLocation W29816580971 @default.

• next