FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981682274> ?p ?o ?g. }

• W2981682274 abstract "Microglia are critical in neuroinflammation. M1/M2 polarization transitions of microglial phenotypes determine the states of neuroinflammation and are regulated by multiple pathways, including miRNAs and other epigenetic regulations. This study investigated the polarization transitions of microglia induced by high glucose and glucose fluctuations, and the role of miR-146a in regulating M1/M2 polarization transitions of microglia. BV-2 cells were cultured with 25 mmol/L glucose, 75 mmol/L glucose, and 25 mmol/L-75 mmol/L glucose fluctuation for 48 h. BV-2 cells overexpressing miR-146a were generated using a lentiviral vector. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure mRNA expression of miR-146a, CD11b, iNOS, Arg-1, IRAK1, TRAF6, and NF-κB. Immunofluorescence was used to measure CD11b expression. Western blot was used to measure protein expression of CD11b, iNOS, and Arg-1. Compared with those in the 25 mmol/L glucose control group, expression of CD11b, iNOS, TNF-α, and IL-6 in the 75 mmol/L glucose or glucose fluctuation groups of cultured BV-2 cells were significantly increased, while Arg-1 and IL-10 was significantly decreased. These effects were reversed by overexpression of miR-146a. Furthermore, expression of IRAK1, TRAF6, and NF-κB was significantly increased in the high glucose and glucose fluctuation groups; this was reduced after miR-146a overexpression. In sum, high glucose and glucose fluctuations induced polarization transitions from M1 to M2 phenotype in BV-2 cells. Overexpression of miR-146a might protect BV-2 cells from high glucose and glucose fluctuation associated with M1/M2 polarization transitions by downregulating the expression of IRAK1, TRAF6, and NF-κB." @default.
• W2981682274 created "2019-11-01" @default.
• W2981682274 creator A5008050009 @default.
• W2981682274 creator A5008248129 @default.
• W2981682274 creator A5012168057 @default.
• W2981682274 creator A5017768395 @default.
• W2981682274 creator A5017972521 @default.
• W2981682274 creator A5036642694 @default.
• W2981682274 creator A5043094856 @default.
• W2981682274 creator A5051460934 @default.
• W2981682274 creator A5086416023 @default.
• W2981682274 date "2019-10-22" @default.
• W2981682274 modified "2023-10-16" @default.
• W2981682274 title "Overexpression of miR-146a Might Regulate Polarization Transitions of BV-2 Cells Induced by High Glucose and Glucose Fluctuations" @default.
• W2981682274 cites W1749888188 @default.
• W2981682274 cites W1768846296 @default.
• W2981682274 cites W1964069071 @default.
• W2981682274 cites W1967109943 @default.
• W2981682274 cites W1970642176 @default.
• W2981682274 cites W1971764287 @default.
• W2981682274 cites W1971984598 @default.
• W2981682274 cites W1984417027 @default.
• W2981682274 cites W1994181115 @default.
• W2981682274 cites W2028247429 @default.
• W2981682274 cites W2033906346 @default.
• W2981682274 cites W2049772720 @default.
• W2981682274 cites W2063206310 @default.
• W2981682274 cites W2069214614 @default.
• W2981682274 cites W2075860675 @default.
• W2981682274 cites W2077124851 @default.
• W2981682274 cites W2079030291 @default.
• W2981682274 cites W2081288890 @default.
• W2981682274 cites W2085878806 @default.
• W2981682274 cites W2086050354 @default.
• W2981682274 cites W2089817450 @default.
• W2981682274 cites W2116152492 @default.
• W2981682274 cites W2146742006 @default.
• W2981682274 cites W2149411404 @default.
• W2981682274 cites W2155605501 @default.
• W2981682274 cites W2156023352 @default.
• W2981682274 cites W2215729635 @default.
• W2981682274 cites W2291209950 @default.
• W2981682274 cites W2298070784 @default.
• W2981682274 cites W2346613219 @default.
• W2981682274 cites W2374285893 @default.
• W2981682274 cites W2535653919 @default.
• W2981682274 cites W2566243927 @default.
• W2981682274 cites W2575251218 @default.
• W2981682274 cites W2593816186 @default.
• W2981682274 cites W2595070070 @default.
• W2981682274 cites W2772162736 @default.
• W2981682274 cites W2783220505 @default.
• W2981682274 cites W2784270707 @default.
• W2981682274 cites W2790927186 @default.
• W2981682274 cites W2889354839 @default.
• W2981682274 cites W2891725583 @default.
• W2981682274 cites W2914365376 @default.
• W2981682274 doi "https://doi.org/10.3389/fendo.2019.00719" @default.
• W2981682274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6817609" @default.
• W2981682274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31695681" @default.
• W2981682274 hasPublicationYear "2019" @default.
• W2981682274 type Work @default.
• W2981682274 sameAs 2981682274 @default.
• W2981682274 citedByCount "14" @default.
• W2981682274 countsByYear W29816822742020 @default.
• W2981682274 countsByYear W29816822742021 @default.
• W2981682274 countsByYear W29816822742022 @default.
• W2981682274 countsByYear W29816822742023 @default.
• W2981682274 crossrefType "journal-article" @default.
• W2981682274 hasAuthorship W2981682274A5008050009 @default.
• W2981682274 hasAuthorship W2981682274A5008248129 @default.
• W2981682274 hasAuthorship W2981682274A5012168057 @default.
• W2981682274 hasAuthorship W2981682274A5017768395 @default.
• W2981682274 hasAuthorship W2981682274A5017972521 @default.
• W2981682274 hasAuthorship W2981682274A5036642694 @default.
• W2981682274 hasAuthorship W2981682274A5043094856 @default.
• W2981682274 hasAuthorship W2981682274A5051460934 @default.
• W2981682274 hasAuthorship W2981682274A5086416023 @default.
• W2981682274 hasBestOaLocation W29816822741 @default.
• W2981682274 hasConcept C104317684 @default.
• W2981682274 hasConcept C126322002 @default.
• W2981682274 hasConcept C134018914 @default.
• W2981682274 hasConcept C153911025 @default.
• W2981682274 hasConcept C165220095 @default.
• W2981682274 hasConcept C171779818 @default.
• W2981682274 hasConcept C185592680 @default.
• W2981682274 hasConcept C2776415932 @default.
• W2981682274 hasConcept C2776914184 @default.
• W2981682274 hasConcept C2779306644 @default.
• W2981682274 hasConcept C2779830541 @default.
• W2981682274 hasConcept C2780963292 @default.
• W2981682274 hasConcept C553184892 @default.
• W2981682274 hasConcept C55493867 @default.
• W2981682274 hasConcept C71924100 @default.
• W2981682274 hasConcept C86803240 @default.
• W2981682274 hasConcept C87753298 @default.
• W2981682274 hasConceptScore W2981682274C104317684 @default.
• W2981682274 hasConceptScore W2981682274C126322002 @default.
• W2981682274 hasConceptScore W2981682274C134018914 @default.
• W2981682274 hasConceptScore W2981682274C153911025 @default.

• next