Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981712741> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2981712741 endingPage "2056" @default.
- W2981712741 startingPage "2051" @default.
- W2981712741 abstract "SUMMARY. In this study a new co-crystal of ticagrelor with quercetin has been fabricated with improved solubility. Ticagrelor is a class VI drug with poor solubility and permeability; hence an attempt has been made to improve its solubility by co-crystallization technology. A co-crystal is a structurally homogeneous crystalline material containing an active pharmaceutical ingredient and the co-former in definite stoichiometric amounts. In this study the conformer selected was quercetin based on ease of hydrogen bond formation and also as quercetin will provide a synergistic effect with ticagrelor. The co-crystal of ticagrelor with quercetin was prepared in two ratios (1:1, 2:1). Ticagrelor formed stable co-crystals in the ratios 1:1 and 2:1. The formation of co-crystal was confirmed by PXRD, DSC, and FTIR. The dynamic solubility of co-crystals in the ratios 1:1 and 2:1 increased by approximately 1.6 fold as compared to pure drug" @default.
- W2981712741 created "2019-11-01" @default.
- W2981712741 creator A5018201331 @default.
- W2981712741 creator A5026030539 @default.
- W2981712741 creator A5027156322 @default.
- W2981712741 creator A5039564497 @default.
- W2981712741 creator A5060809795 @default.
- W2981712741 creator A5063624647 @default.
- W2981712741 date "2019-01-01" @default.
- W2981712741 modified "2023-09-23" @default.
- W2981712741 title "Solubility Enhancement of Ticagrelor by Co-Crystal Technology: Preparation, Solid State Characterization and Solubility Studies" @default.
- W2981712741 hasPublicationYear "2019" @default.
- W2981712741 type Work @default.
- W2981712741 sameAs 2981712741 @default.
- W2981712741 citedByCount "0" @default.
- W2981712741 crossrefType "journal-article" @default.
- W2981712741 hasAuthorship W2981712741A5018201331 @default.
- W2981712741 hasAuthorship W2981712741A5026030539 @default.
- W2981712741 hasAuthorship W2981712741A5027156322 @default.
- W2981712741 hasAuthorship W2981712741A5039564497 @default.
- W2981712741 hasAuthorship W2981712741A5060809795 @default.
- W2981712741 hasAuthorship W2981712741A5063624647 @default.
- W2981712741 hasConcept C155574463 @default.
- W2981712741 hasConcept C178790620 @default.
- W2981712741 hasConcept C185592680 @default.
- W2981712741 hasConcept C192562407 @default.
- W2981712741 hasConcept C199360897 @default.
- W2981712741 hasConcept C203036418 @default.
- W2981712741 hasConcept C2777628954 @default.
- W2981712741 hasConcept C2777849778 @default.
- W2981712741 hasConcept C2778004101 @default.
- W2981712741 hasConcept C2780890252 @default.
- W2981712741 hasConcept C2781263971 @default.
- W2981712741 hasConcept C2781285689 @default.
- W2981712741 hasConcept C41008148 @default.
- W2981712741 hasConcept C55493867 @default.
- W2981712741 hasConceptScore W2981712741C155574463 @default.
- W2981712741 hasConceptScore W2981712741C178790620 @default.
- W2981712741 hasConceptScore W2981712741C185592680 @default.
- W2981712741 hasConceptScore W2981712741C192562407 @default.
- W2981712741 hasConceptScore W2981712741C199360897 @default.
- W2981712741 hasConceptScore W2981712741C203036418 @default.
- W2981712741 hasConceptScore W2981712741C2777628954 @default.
- W2981712741 hasConceptScore W2981712741C2777849778 @default.
- W2981712741 hasConceptScore W2981712741C2778004101 @default.
- W2981712741 hasConceptScore W2981712741C2780890252 @default.
- W2981712741 hasConceptScore W2981712741C2781263971 @default.
- W2981712741 hasConceptScore W2981712741C2781285689 @default.
- W2981712741 hasConceptScore W2981712741C41008148 @default.
- W2981712741 hasConceptScore W2981712741C55493867 @default.
- W2981712741 hasIssue "10" @default.
- W2981712741 hasOpenAccess W2981712741 @default.
- W2981712741 hasRelatedWork W1746981052 @default.
- W2981712741 hasRelatedWork W1999081750 @default.
- W2981712741 hasRelatedWork W2054324989 @default.
- W2981712741 hasRelatedWork W2143408925 @default.
- W2981712741 hasRelatedWork W2181408509 @default.
- W2981712741 hasRelatedWork W2181450659 @default.
- W2981712741 hasRelatedWork W2231631037 @default.
- W2981712741 hasRelatedWork W2560448833 @default.
- W2981712741 hasRelatedWork W2613451810 @default.
- W2981712741 hasRelatedWork W2768979628 @default.
- W2981712741 hasRelatedWork W2889481762 @default.
- W2981712741 hasRelatedWork W2902400493 @default.
- W2981712741 hasRelatedWork W2942213745 @default.
- W2981712741 hasRelatedWork W2943948452 @default.
- W2981712741 hasRelatedWork W2964490555 @default.
- W2981712741 hasRelatedWork W2998752916 @default.
- W2981712741 hasRelatedWork W3047364491 @default.
- W2981712741 hasRelatedWork W3090907464 @default.
- W2981712741 hasRelatedWork W3167813307 @default.
- W2981712741 hasRelatedWork W2289543005 @default.
- W2981712741 hasVolume "38" @default.
- W2981712741 isParatext "false" @default.
- W2981712741 isRetracted "false" @default.
- W2981712741 magId "2981712741" @default.
- W2981712741 workType "article" @default.