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- W2981738352 abstract "Pyrethroid pesticides were used preferably over organochlorines and organophosphates due to theirhigh effectiveness, low toxicity to non-target organisms and easy biodegrability. It has widespread applicationsin agriculture through the world resulting in increased human exposure to this compound. Theaim of present study was to evaluate the possible protective effect of propolis on hepatotoxic effect causedby cypermethrin in adult male Albino rats. Fifty adult male albino rats were included in the current studyand classified into 4 groups. Group I (control) subdivided into (a): negative control reclived 2ml salinearally daily and (b): positive control received orally daily 2 ml corn oil. Group II: received orally daily(cypermethrin 14.5 mg/kg) dissolved in corn oil. Group III: received orally daily (propolis 200 mg/kg)dissolved in saline. GroupIV: received orally daily (cypermethrin 14.5 mg/kg dissolved in corn oil + propolis200 mg/kg dissolved in saline). After 4 weeks of treatment, blood samples were collected for estimationof the levels of liver enzymes [ alanine aminotransferase (ALT), aspartate aminotransferase(AST), alkaline phosphatase (ALP)], total proteins, albumin, total cholesterol, triglyceride, very low densitylipoprotein-cholesterol (VLDL-c), then rats were sacrificed, the liver was excised, and subjected toestimation of levels of malondialdehyde (MDA), antioxidant enzymes [catalase (CAT), superoxide dismutase(SOD), glutathion peroxidase (GPx)], and histopathological examination. Cypermethrin induced asignificant increase in the levels of liver enzymes, total cholesterol, and MDA. While total protein, albumin,triglyceride, VLDL-c and antioxidant enzymes were decreased when compared to control rats. Histopathologicalexamination of the liver revealed congestion of central and portal veins with hydropic degenerationof hepatocytes. Propolis administration with cypermethrin induced a significant decrease inlevels of liver enzymes, total cholesterol and MDA and a significant increase in the levels of antioxidantenzymes, total protein, triglyceride and VLDL-c. Histopathological examination of the liver revealed apparentimprovement of lesions induced by cypermethrin. It was concluded that propolis has a beneficialinfluences in reducing the hepatotoxic effects of cypermethrin in male Albino rats." @default.
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- W2981738352 date "2011-01-01" @default.
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- W2981738352 title "The Possible Protective Effect of Propolis (Bee Glue) on Cypermethrin-Induced Hepatotoxicity in Adult Albino Rats" @default.
- W2981738352 doi "https://doi.org/10.21608/mjfmct.2011.55319" @default.
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