Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981745152> ?p ?o ?g. }
- W2981745152 abstract "Retinoic acid receptor γ (RARγ) belongs to the nuclear receptor superfamily and shares 90% homology with retinoic acid receptor α (RARα) and retinoic acid receptor β (RARβ). RARA rearrangements are well-known to be involved in acute promyelocytic leukemia (APL), but RARG rearrangements can also resemble this kind of leukemia. In this review we trace the role of RARγ, considering both its physiological and oncogenic contribution; from 2011 to date, nine cases of patients harboring RARG fusions have been reported. These patients showed typical APL features, including the clinical presentation, coagulation abnormalities and morphological features of bone marrow (BM), but are not responsive to APL standard therapy. We stress the urgent need for a better comprehension of the critical role of RARG dysregulation in the leukemogenesis process, since optimum therapy strategies have not yet been established." @default.
- W2981745152 created "2019-11-01" @default.
- W2981745152 creator A5018342329 @default.
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- W2981745152 creator A5063955932 @default.
- W2981745152 creator A5073711573 @default.
- W2981745152 date "2019-10-24" @default.
- W2981745152 modified "2023-10-17" @default.
- W2981745152 title "RARG Gene Dysregulation in Acute Myeloid Leukemia" @default.
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- W2981745152 doi "https://doi.org/10.3389/fmolb.2019.00114" @default.
- W2981745152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6822255" @default.
- W2981745152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31709264" @default.
- W2981745152 hasPublicationYear "2019" @default.
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