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- W2981781723 abstract "The success of genetically engineered T-cells modified with a chimeric antigen receptor as an adoptive cell immunotherapy and the subsequent last regulatory approvals of products based on this therapy are leading to a crescent number of both academic and pharmaceutical industry clinical trials testing new approaches of this living drugs. The aim of this review is to outline the latest developments and regulatory considerations in this field, with a particular emphasis to differences and similarities between academic and industry approaches and the role they should play to coexist and move forward together. To do that, the main considerations for the manufacturing process are firstly discussed, from the chimeric antigen receptor design to final production steps, passing through ex vivo T-cell handling, gene delivery methods, patient´s final product infusion observations or possible associated side effects of this treatment." @default.
- W2981781723 created "2019-11-01" @default.
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- W2981781723 date "2020-01-01" @default.
- W2981781723 modified "2023-10-17" @default.
- W2981781723 title "CART manufacturing process and reasons for academy-pharma collaboration" @default.
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- W2981781723 doi "https://doi.org/10.1016/j.imlet.2019.10.014" @default.
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