FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981784096> ?p ?o ?g. }

• W2981784096 endingPage "e1008341" @default.
• W2981784096 startingPage "e1008341" @default.
• W2981784096 abstract "In order to respond to changing environments and fluctuations in internal states, animals adjust their behavior through diverse neuromodulatory mechanisms. In this study we show that electrical synapses between the ASH primary quinine-detecting sensory neurons and the neighboring ASK neurons are required for modulating the aversive response to the bitter tastant quinine in C. elegans. Mutant worms that lack the electrical synapse proteins INX-18 and INX-19 become hypersensitive to dilute quinine. Cell-specific rescue experiments indicate that inx-18 operates in ASK while inx-19 is required in both ASK and ASH for proper quinine sensitivity. Imaging analyses find that INX-19 in ASK and ASH localizes to the same regions in the nerve ring, suggesting that both sides of ASK-ASH electrical synapses contain INX-19. While inx-18 and inx-19 mutant animals have a similar behavioral phenotype, several lines of evidence suggest the proteins encoded by these genes play different roles in modulating the aversive quinine response. First, INX-18 and INX-19 localize to different regions of the nerve ring, indicating that they are not present in the same synapses. Second, removing inx-18 disrupts the distribution of INX-19, while removing inx-19 does not alter INX-18 localization. Finally, by using a fluorescent cGMP reporter, we find that INX-18 and INX-19 have distinct roles in establishing cGMP levels in ASK and ASH. Together, these results demonstrate that electrical synapses containing INX-18 and INX-19 facilitate modulation of ASH nociceptive signaling. Our findings support the idea that a network of electrical synapses mediates cGMP exchange between neurons, enabling modulation of sensory responses and behavior." @default.
• W2981784096 created "2019-11-01" @default.
• W2981784096 creator A5002374231 @default.
• W2981784096 creator A5048156775 @default.
• W2981784096 creator A5049845282 @default.
• W2981784096 creator A5055277758 @default.
• W2981784096 creator A5069611985 @default.
• W2981784096 creator A5077367690 @default.
• W2981784096 creator A5084466372 @default.
• W2981784096 date "2019-10-28" @default.
• W2981784096 modified "2023-10-03" @default.
• W2981784096 title "INX-18 and INX-19 play distinct roles in electrical synapses that modulate aversive behavior in Caenorhabditis elegans" @default.
• W2981784096 cites W1487910746 @default.
• W2981784096 cites W1960493235 @default.
• W2981784096 cites W1965404074 @default.
• W2981784096 cites W1979173978 @default.
• W2981784096 cites W1985602726 @default.
• W2981784096 cites W1985791091 @default.
• W2981784096 cites W1987391644 @default.
• W2981784096 cites W1987594610 @default.
• W2981784096 cites W1991763978 @default.
• W2981784096 cites W2005327453 @default.
• W2981784096 cites W2010971951 @default.
• W2981784096 cites W2013143265 @default.
• W2981784096 cites W2013800225 @default.
• W2981784096 cites W2016016611 @default.
• W2981784096 cites W2018272303 @default.
• W2981784096 cites W2018341419 @default.
• W2981784096 cites W2022221238 @default.
• W2981784096 cites W2024461475 @default.
• W2981784096 cites W2027352768 @default.
• W2981784096 cites W2027822459 @default.
• W2981784096 cites W2030676914 @default.
• W2981784096 cites W2041014723 @default.
• W2981784096 cites W2044981043 @default.
• W2981784096 cites W2050350002 @default.
• W2981784096 cites W2054486575 @default.
• W2981784096 cites W2054914622 @default.
• W2981784096 cites W2055011117 @default.
• W2981784096 cites W2056685629 @default.
• W2981784096 cites W2057334944 @default.
• W2981784096 cites W2057596490 @default.
• W2981784096 cites W2058665312 @default.
• W2981784096 cites W2058767256 @default.
• W2981784096 cites W2070217895 @default.
• W2981784096 cites W2071769324 @default.
• W2981784096 cites W2072474554 @default.
• W2981784096 cites W2072681733 @default.
• W2981784096 cites W2077952608 @default.
• W2981784096 cites W2083605893 @default.
• W2981784096 cites W2087119884 @default.
• W2981784096 cites W2088851910 @default.
• W2981784096 cites W2106789000 @default.
• W2981784096 cites W2109898640 @default.
• W2981784096 cites W2112927743 @default.
• W2981784096 cites W2119753879 @default.
• W2981784096 cites W2122678512 @default.
• W2981784096 cites W2127026598 @default.
• W2981784096 cites W2131096662 @default.
• W2981784096 cites W2132350109 @default.
• W2981784096 cites W2133849127 @default.
• W2981784096 cites W2137259906 @default.
• W2981784096 cites W2141114982 @default.
• W2981784096 cites W2144751398 @default.
• W2981784096 cites W2149001956 @default.
• W2981784096 cites W2149436258 @default.
• W2981784096 cites W2150857286 @default.
• W2981784096 cites W2160938187 @default.
• W2981784096 cites W2162624621 @default.
• W2981784096 cites W2166886630 @default.
• W2981784096 cites W2167279371 @default.
• W2981784096 cites W2168112956 @default.
• W2981784096 cites W2171332611 @default.
• W2981784096 cites W2313367492 @default.
• W2981784096 cites W2345968315 @default.
• W2981784096 cites W2400303251 @default.
• W2981784096 cites W2485558360 @default.
• W2981784096 cites W2515726425 @default.
• W2981784096 cites W2519623943 @default.
• W2981784096 cites W2569173440 @default.
• W2981784096 cites W2580678460 @default.
• W2981784096 cites W2603888174 @default.
• W2981784096 cites W2949267911 @default.
• W2981784096 cites W2954731284 @default.
• W2981784096 cites W2962791731 @default.
• W2981784096 cites W4241353914 @default.
• W2981784096 cites W4244715363 @default.
• W2981784096 doi "https://doi.org/10.1371/journal.pgen.1008341" @default.
• W2981784096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6837551" @default.
• W2981784096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31658255" @default.
• W2981784096 hasPublicationYear "2019" @default.
• W2981784096 type Work @default.
• W2981784096 sameAs 2981784096 @default.
• W2981784096 citedByCount "7" @default.
• W2981784096 countsByYear W29817840962020 @default.
• W2981784096 countsByYear W29817840962021 @default.
• W2981784096 countsByYear W29817840962022 @default.
• W2981784096 countsByYear W29817840962023 @default.

• next