FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981798045> ?p ?o ?g. }

• W2981798045 endingPage "113" @default.
• W2981798045 startingPage "106" @default.
• W2981798045 abstract "Rheumatoid arthritis (RA) is one of the most common prevalent autoimmune diseases. The 1858 C/T (rs2476601) single nucleotide polymorphism (SNP) within the PTPN22 gene has been associated with susceptibility to inflammatory based diseases in several populations. It is implicated that altered cytokine production has a potential pathogenic role in the development of RA. The aim of this work was to analyze the association of 1858 C/T PTPN22 polymorphism in RA patients with cytokine profiles. This study was performed on 120 RA patients who were referred to the Rheumatology Research Centre, Shariati Hospital (Tehran, Iran), and 120 healthy controls. Genomic DNA was extracted and genotyped for 1858 C/T PTPN22 gene SNP using the PCR-RFLP technique. Serum levels of IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ as well as Anti−CCP and RF was measured by ELISA method. Results showed that 1858 C/T PTPN22 SNP significantly (P = 0.007, OR = 2.321, 95% CI = 1.063–5.067) associated with RA. The 1858 T allele frequency was also significantly increased in RA patients in comparison to the controls (P = 0.008, OR = 3.583, 95% CI = 1.3–9.878). Our data demonstrated a significant reduction of IL-4 and IL-10 in PTPN22 1858C/T compared to 1858C/C RA patients. In addition, upregulation of IL-6, IFN-γ, and TNF-α was observed in PTPN22 1858C/T vs. 1858C/C RA patients. Our findings implicate altered cytokine profiles as a possible pathogenic mechanism by which the 1858 T allele may contribute to the progress of RA." @default.
• W2981798045 created "2019-11-01" @default.
• W2981798045 creator A5003332468 @default.
• W2981798045 creator A5006847840 @default.
• W2981798045 creator A5027393143 @default.
• W2981798045 creator A5027650394 @default.
• W2981798045 creator A5035891166 @default.
• W2981798045 creator A5049587458 @default.
• W2981798045 creator A5049660890 @default.
• W2981798045 creator A5070207775 @default.
• W2981798045 date "2019-12-01" @default.
• W2981798045 modified "2023-09-26" @default.
• W2981798045 title "PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis" @default.
• W2981798045 cites W1485475535 @default.
• W2981798045 cites W1866959257 @default.
• W2981798045 cites W1912641271 @default.
• W2981798045 cites W1913318416 @default.
• W2981798045 cites W1967857969 @default.
• W2981798045 cites W1973173778 @default.
• W2981798045 cites W1978117435 @default.
• W2981798045 cites W1987677365 @default.
• W2981798045 cites W1990420620 @default.
• W2981798045 cites W1994402720 @default.
• W2981798045 cites W2002599058 @default.
• W2981798045 cites W2003207115 @default.
• W2981798045 cites W2007314153 @default.
• W2981798045 cites W2008649874 @default.
• W2981798045 cites W2010419404 @default.
• W2981798045 cites W2010490337 @default.
• W2981798045 cites W2017347101 @default.
• W2981798045 cites W2024235219 @default.
• W2981798045 cites W2027766287 @default.
• W2981798045 cites W2032169254 @default.
• W2981798045 cites W2032489310 @default.
• W2981798045 cites W2044337817 @default.
• W2981798045 cites W2044890039 @default.
• W2981798045 cites W2054355572 @default.
• W2981798045 cites W2061819326 @default.
• W2981798045 cites W2069949136 @default.
• W2981798045 cites W2078918202 @default.
• W2981798045 cites W2079078071 @default.
• W2981798045 cites W2087265576 @default.
• W2981798045 cites W2101324880 @default.
• W2981798045 cites W2110709185 @default.
• W2981798045 cites W2111199584 @default.
• W2981798045 cites W2111978305 @default.
• W2981798045 cites W2118418739 @default.
• W2981798045 cites W2121273196 @default.
• W2981798045 cites W2124213380 @default.
• W2981798045 cites W2128952811 @default.
• W2981798045 cites W2132857823 @default.
• W2981798045 cites W2135167801 @default.
• W2981798045 cites W2135197636 @default.
• W2981798045 cites W2142155452 @default.
• W2981798045 cites W2146050040 @default.
• W2981798045 cites W2149076123 @default.
• W2981798045 cites W2152651398 @default.
• W2981798045 cites W2165052240 @default.
• W2981798045 cites W2166330972 @default.
• W2981798045 cites W2167133159 @default.
• W2981798045 cites W2529321751 @default.
• W2981798045 cites W2757543759 @default.
• W2981798045 cites W2900067365 @default.
• W2981798045 cites W4211111012 @default.
• W2981798045 doi "https://doi.org/10.1016/j.imlet.2019.10.010" @default.
• W2981798045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31669381" @default.
• W2981798045 hasPublicationYear "2019" @default.
• W2981798045 type Work @default.
• W2981798045 sameAs 2981798045 @default.
• W2981798045 citedByCount "6" @default.
• W2981798045 countsByYear W29817980452020 @default.
• W2981798045 countsByYear W29817980452021 @default.
• W2981798045 crossrefType "journal-article" @default.
• W2981798045 hasAuthorship W2981798045A5003332468 @default.
• W2981798045 hasAuthorship W2981798045A5006847840 @default.
• W2981798045 hasAuthorship W2981798045A5027393143 @default.
• W2981798045 hasAuthorship W2981798045A5027650394 @default.
• W2981798045 hasAuthorship W2981798045A5035891166 @default.
• W2981798045 hasAuthorship W2981798045A5049587458 @default.
• W2981798045 hasAuthorship W2981798045A5049660890 @default.
• W2981798045 hasAuthorship W2981798045A5070207775 @default.
• W2981798045 hasConcept C104317684 @default.
• W2981798045 hasConcept C126322002 @default.
• W2981798045 hasConcept C135763542 @default.
• W2981798045 hasConcept C139275648 @default.
• W2981798045 hasConcept C153209595 @default.
• W2981798045 hasConcept C180754005 @default.
• W2981798045 hasConcept C198451711 @default.
• W2981798045 hasConcept C203014093 @default.
• W2981798045 hasConcept C2777077863 @default.
• W2981798045 hasConcept C2777575956 @default.
• W2981798045 hasConcept C2778690821 @default.
• W2981798045 hasConcept C2779356809 @default.
• W2981798045 hasConcept C54355233 @default.
• W2981798045 hasConcept C71924100 @default.
• W2981798045 hasConcept C86803240 @default.
• W2981798045 hasConceptScore W2981798045C104317684 @default.
• W2981798045 hasConceptScore W2981798045C126322002 @default.

• next