FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981809162> ?p ?o ?g. }

• W2981809162 endingPage "643" @default.
• W2981809162 startingPage "643" @default.
• W2981809162 abstract "A series of seven chalcone-thiosemicarbazones (5a-5g) were synthesized and evaluated as potential new drugs (anti-leishmanial effect). Although four of the chalcone-thiosemicarbazones are already known, none of them or any compound in this class has been previously investigated for their effects on parasites of the Leishmania genus. The compounds were prepared in satisfactory yields (40-75%) and these compounds were evaluated against promastigotes, axenic amastigotes and intracellular amastigotes of L. amazonensis after 48 h of culture. The half maximal inhibitory concentration (IC50) values of the intracellular amastigotes were determined to be in the range of 3.40 to 5.95 µM for all compounds assayed. The selectivity index showed value of 15.05 for 5a, whereas pentamidine (reference drug) was more toxic in our model (SI = 2.32). Furthermore, to understand the preliminary relationship between the anti-leishmanial activity of the chalcone-thiosemicarbazones, their electronic (σ), steric (MR) and lipophilicity (π) properties were correlated, and the results indicated that moieties with electronic withdrawing effects increase the anti-leishmanial activity. The preliminary pharmacokinetic evaluation of one of the most active compound (5e) was studied via interaction to human serum albumin (HSA) using multiple spectroscopic techniques combined with molecular docking. The results of antiparasitic effects against L. amazonensis revealed the chalcone-thiosemicarbazone class to be novel prototypes for drug development against leishmaniasis." @default.
• W2981809162 created "2019-11-01" @default.
• W2981809162 creator A5010116555 @default.
• W2981809162 creator A5017076792 @default.
• W2981809162 creator A5018633899 @default.
• W2981809162 creator A5033048512 @default.
• W2981809162 creator A5048696169 @default.
• W2981809162 creator A5052311645 @default.
• W2981809162 creator A5082616055 @default.
• W2981809162 creator A5085702225 @default.
• W2981809162 date "2019-10-23" @default.
• W2981809162 modified "2023-10-07" @default.
• W2981809162 title "Evaluation of Novel Chalcone-Thiosemicarbazones Derivatives as Potential Anti-Leishmania amazonensis Agents and Its HSA Binding Studies" @default.
• W2981809162 cites W1427704710 @default.
• W2981809162 cites W1574199013 @default.
• W2981809162 cites W1842770465 @default.
• W2981809162 cites W1964498574 @default.
• W2981809162 cites W1970790420 @default.
• W2981809162 cites W1981470144 @default.
• W2981809162 cites W1982764408 @default.
• W2981809162 cites W1986854506 @default.
• W2981809162 cites W2001312913 @default.
• W2981809162 cites W2002171555 @default.
• W2981809162 cites W2004006450 @default.
• W2981809162 cites W2014785403 @default.
• W2981809162 cites W2016401253 @default.
• W2981809162 cites W2018516313 @default.
• W2981809162 cites W2021556172 @default.
• W2981809162 cites W2026447666 @default.
• W2981809162 cites W2053245283 @default.
• W2981809162 cites W2056529056 @default.
• W2981809162 cites W2061394187 @default.
• W2981809162 cites W2063800748 @default.
• W2981809162 cites W2065828976 @default.
• W2981809162 cites W2072084351 @default.
• W2981809162 cites W2075705506 @default.
• W2981809162 cites W2086075183 @default.
• W2981809162 cites W2089718652 @default.
• W2981809162 cites W2114918609 @default.
• W2981809162 cites W2129248276 @default.
• W2981809162 cites W2139163648 @default.
• W2981809162 cites W2142869187 @default.
• W2981809162 cites W2145701935 @default.
• W2981809162 cites W2160728506 @default.
• W2981809162 cites W2166203745 @default.
• W2981809162 cites W2313225354 @default.
• W2981809162 cites W2316001993 @default.
• W2981809162 cites W2328544433 @default.
• W2981809162 cites W2410228809 @default.
• W2981809162 cites W2469988999 @default.
• W2981809162 cites W2605090806 @default.
• W2981809162 cites W2610790488 @default.
• W2981809162 cites W2765615677 @default.
• W2981809162 cites W2791850503 @default.
• W2981809162 cites W2888578154 @default.
• W2981809162 cites W2909292069 @default.
• W2981809162 cites W2913051161 @default.
• W2981809162 cites W2915769510 @default.
• W2981809162 cites W2915788545 @default.
• W2981809162 cites W2030162611 @default.
• W2981809162 doi "https://doi.org/10.3390/biom9110643" @default.
• W2981809162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6920794" @default.
• W2981809162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31652866" @default.
• W2981809162 hasPublicationYear "2019" @default.
• W2981809162 type Work @default.
• W2981809162 sameAs 2981809162 @default.
• W2981809162 citedByCount "11" @default.
• W2981809162 countsByYear W29818091622021 @default.
• W2981809162 countsByYear W29818091622022 @default.
• W2981809162 countsByYear W29818091622023 @default.
• W2981809162 crossrefType "journal-article" @default.
• W2981809162 hasAuthorship W2981809162A5010116555 @default.
• W2981809162 hasAuthorship W2981809162A5017076792 @default.
• W2981809162 hasAuthorship W2981809162A5018633899 @default.
• W2981809162 hasAuthorship W2981809162A5033048512 @default.
• W2981809162 hasAuthorship W2981809162A5048696169 @default.
• W2981809162 hasAuthorship W2981809162A5052311645 @default.
• W2981809162 hasAuthorship W2981809162A5082616055 @default.
• W2981809162 hasAuthorship W2981809162A5085702225 @default.
• W2981809162 hasBestOaLocation W29818091621 @default.
• W2981809162 hasConcept C136764020 @default.
• W2981809162 hasConcept C185592680 @default.
• W2981809162 hasConcept C201399114 @default.
• W2981809162 hasConcept C202751555 @default.
• W2981809162 hasConcept C2777752497 @default.
• W2981809162 hasConcept C2780764945 @default.
• W2981809162 hasConcept C2781092759 @default.
• W2981809162 hasConcept C41008148 @default.
• W2981809162 hasConcept C55493867 @default.
• W2981809162 hasConcept C71240020 @default.
• W2981809162 hasConcept C71928629 @default.
• W2981809162 hasConcept C79879829 @default.
• W2981809162 hasConcept C86803240 @default.
• W2981809162 hasConcept C98274493 @default.
• W2981809162 hasConcept C98319499 @default.
• W2981809162 hasConceptScore W2981809162C136764020 @default.
• W2981809162 hasConceptScore W2981809162C185592680 @default.
• W2981809162 hasConceptScore W2981809162C201399114 @default.

• next