Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981820005> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W2981820005 endingPage "1" @default.
- W2981820005 startingPage "1" @default.
- W2981820005 abstract "Phage as an anti-bacterial agent must be efficient in killing bacteria, and consequently needs to replicate efficiently. Protein production is a limiting step in replication in almost all forms of life, including phages. Efficient protein production depends on the efficiency of translation initiation, elongation and termination, with translation initiation often being rate limiting. Initiation signals such as Shine-Dalgarno (SD) sequences and start codon are decoded by anti-SD sequences and initiation tRNA, respectively. While the decoding machinery cannot be readily modified, the signals can be engineered to increase the efficiency of their decoding. Here I review our understanding of the translation machinery to facilitate the engineering of optimal translation initiation signals for facilitating the design of phage protein-coding genes, including 1) accurate characterization of the 3’ end of 16S rRNA by using RNA-Seq data, 2) identification of the optimal SD/aSD interaction, and 3) reduction of secondary structure in sequences flanking the start codon." @default.
- W2981820005 created "2019-11-01" @default.
- W2981820005 creator A5059534273 @default.
- W2981820005 date "2019-06-09" @default.
- W2981820005 modified "2023-09-27" @default.
- W2981820005 title "Optimizing Phage Translation Initiation" @default.
- W2981820005 doi "https://doi.org/10.21926/obm.genet.1904097" @default.
- W2981820005 hasPublicationYear "2019" @default.
- W2981820005 type Work @default.
- W2981820005 sameAs 2981820005 @default.
- W2981820005 citedByCount "3" @default.
- W2981820005 countsByYear W29818200052020 @default.
- W2981820005 countsByYear W29818200052021 @default.
- W2981820005 countsByYear W29818200052023 @default.
- W2981820005 crossrefType "journal-article" @default.
- W2981820005 hasAuthorship W2981820005A5059534273 @default.
- W2981820005 hasBestOaLocation W29818200051 @default.
- W2981820005 hasConcept C104317684 @default.
- W2981820005 hasConcept C105580179 @default.
- W2981820005 hasConcept C149364088 @default.
- W2981820005 hasConcept C41008148 @default.
- W2981820005 hasConcept C54355233 @default.
- W2981820005 hasConcept C70721500 @default.
- W2981820005 hasConcept C86803240 @default.
- W2981820005 hasConceptScore W2981820005C104317684 @default.
- W2981820005 hasConceptScore W2981820005C105580179 @default.
- W2981820005 hasConceptScore W2981820005C149364088 @default.
- W2981820005 hasConceptScore W2981820005C41008148 @default.
- W2981820005 hasConceptScore W2981820005C54355233 @default.
- W2981820005 hasConceptScore W2981820005C70721500 @default.
- W2981820005 hasConceptScore W2981820005C86803240 @default.
- W2981820005 hasIssue "4" @default.
- W2981820005 hasLocation W29818200051 @default.
- W2981820005 hasOpenAccess W2981820005 @default.
- W2981820005 hasPrimaryLocation W29818200051 @default.
- W2981820005 hasRelatedWork W2031014255 @default.
- W2981820005 hasRelatedWork W2068868065 @default.
- W2981820005 hasRelatedWork W2509777158 @default.
- W2981820005 hasRelatedWork W2600672786 @default.
- W2981820005 hasRelatedWork W2764188251 @default.
- W2981820005 hasRelatedWork W2932166412 @default.
- W2981820005 hasRelatedWork W3006786463 @default.
- W2981820005 hasRelatedWork W3196333218 @default.
- W2981820005 hasRelatedWork W4281387726 @default.
- W2981820005 hasRelatedWork W97426361 @default.
- W2981820005 hasVolume "3" @default.
- W2981820005 isParatext "false" @default.
- W2981820005 isRetracted "false" @default.
- W2981820005 magId "2981820005" @default.
- W2981820005 workType "article" @default.