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- W2981831888 abstract "Human embryonic stem cell (hESC)-based developmental toxicity models can help to reduce animal testing and mitigate inter-species variability. However, current hESC models do not fully recapitulate embryonic developmental structural changes, which are underpinned by spatio-temporally controlled differentiation and migration events. We show that mechanical polarization imposed by cell micropatterning could spatially pattern hESC differentiation and migration, and in turn reconstituted a rudimentary structural motif. Features of this structural motif were disrupted by paradigm developmental toxins but not a negative control drug. This novel micropatterned hESC model can potentially be scaled- up into an array format for high throughput developmental toxicity screening." @default.
- W2981831888 created "2019-11-01" @default.
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- W2981831888 date "2013-01-01" @default.
- W2981831888 modified "2023-09-27" @default.
- W2981831888 title "A micropatterned human embryonic stem cell model for in vitro human developmental toxicity testing" @default.
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