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• W2981852166 abstract "Vitamin D has a long-established role in bone health. In the last two decades, there has been a dramatic resurgence in research interest in vitamin D due to studies that have shown its possible benefits for non-skeletal health. Underpinning the renewed interest in vitamin D was the identification of the vital role of intracrine or localized, tissue-specific, conversion of inactive pro-hormone 25-hydroxyvitamin D [25(OH)D] to active 1,25-dihydroxyvitamin D [1,25(OH)2D]. This intracrine mechanism is the likely driving force behind vitamin D action resulting in positive effects on human health. To fully capture the effect of this localized, tissue-specific conversion to 1,25(OH)2D, adequate 25(OH)D would be required. As such, low serum concentrations of 25(OH)D would compromise intracrine generation of 1,25(OH)2D within target tissues. Consistent with this is the observation that all adverse human health consequences of vitamin D deficiency are associated with a low serum 25(OH)D level and not with low 1,25(OH)2D concentrations. Thus, clinical investigators have sought to define what concentration of serum 25(OH)D constitutes adequate vitamin D status. However, since 25(OH)D is transported in serum bound primarily to vitamin D binding protein (DBP) and secondarily to albumin, is the total 25(OH)D (bound plus free) or the unbound free 25(OH)D the crucial determinant of the non-classical actions of vitamin D? While DBP-bound-25(OH)D is important for renal handling of 25(OH)D and endocrine synthesis of 1,25(OH)2D, how does DBP impact extra-renal synthesis of 1,25(OH)2D and subsequent 1,25(OH)2D actions? Are their pathophysiological contexts where total 25(OH)D and free 25(OH)D would diverge in value as a marker of vitamin D status? This review aims to introduce and discuss the concept of free 25(OH)D, the molecular biology and biochemistry of vitamin D and DBP that provides the context for free 25(OH)D, and surveys in vitro, animal, and human studies taking free 25(OH)D into consideration." @default.
• W2981852166 created "2019-11-01" @default.
• W2981852166 creator A5002664548 @default.
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• W2981852166 creator A5085416836 @default.
• W2981852166 date "2019-10-24" @default.
• W2981852166 modified "2023-10-16" @default.
• W2981852166 title "Vitamin D Binding Protein and the Biological Activity of Vitamin D" @default.
• W2981852166 cites W1514081838 @default.
• W2981852166 cites W1551028857 @default.
• W2981852166 cites W1599765837 @default.
• W2981852166 cites W1709580159 @default.
• W2981852166 cites W171316058 @default.
• W2981852166 cites W1822852286 @default.
• W2981852166 cites W1835669868 @default.
• W2981852166 cites W1866685620 @default.
• W2981852166 cites W1900039427 @default.
• W2981852166 cites W1916465006 @default.
• W2981852166 cites W1929445834 @default.
• W2981852166 cites W1965943515 @default.
• W2981852166 cites W1967604492 @default.
• W2981852166 cites W1970447061 @default.
• W2981852166 cites W1970536654 @default.
• W2981852166 cites W1971253104 @default.
• W2981852166 cites W1973338388 @default.
• W2981852166 cites W1976472175 @default.
• W2981852166 cites W1983383660 @default.
• W2981852166 cites W1984685554 @default.
• W2981852166 cites W1988738875 @default.
• W2981852166 cites W1991608675 @default.
• W2981852166 cites W1995941679 @default.
• W2981852166 cites W1997847863 @default.
• W2981852166 cites W1999520741 @default.
• W2981852166 cites W1999541971 @default.
• W2981852166 cites W2003923148 @default.
• W2981852166 cites W2005709260 @default.
• W2981852166 cites W2007331929 @default.
• W2981852166 cites W2011114445 @default.
• W2981852166 cites W2011725731 @default.
• W2981852166 cites W2016809520 @default.
• W2981852166 cites W2017851530 @default.
• W2981852166 cites W2018196330 @default.
• W2981852166 cites W2020796644 @default.
• W2981852166 cites W2021380980 @default.
• W2981852166 cites W2021852822 @default.
• W2981852166 cites W2022860847 @default.
• W2981852166 cites W2023787027 @default.
• W2981852166 cites W2025844751 @default.
• W2981852166 cites W2028287104 @default.
• W2981852166 cites W2028927099 @default.
• W2981852166 cites W2031326112 @default.
• W2981852166 cites W2031778933 @default.
• W2981852166 cites W2034711694 @default.
• W2981852166 cites W2036640577 @default.
• W2981852166 cites W2038118096 @default.
• W2981852166 cites W2038469606 @default.
• W2981852166 cites W2040926938 @default.
• W2981852166 cites W2050777099 @default.
• W2981852166 cites W2051812037 @default.
• W2981852166 cites W2051909250 @default.
• W2981852166 cites W2052505493 @default.
• W2981852166 cites W2052677570 @default.
• W2981852166 cites W2056910995 @default.
• W2981852166 cites W2061244704 @default.
• W2981852166 cites W2062361583 @default.
• W2981852166 cites W2064347855 @default.
• W2981852166 cites W2065321690 @default.
• W2981852166 cites W2069429971 @default.
• W2981852166 cites W2069678913 @default.
• W2981852166 cites W2070667772 @default.
• W2981852166 cites W2071467913 @default.
• W2981852166 cites W2071921882 @default.
• W2981852166 cites W2073414064 @default.
• W2981852166 cites W2074610576 @default.
• W2981852166 cites W2075340346 @default.
• W2981852166 cites W2076462603 @default.
• W2981852166 cites W2076920867 @default.
• W2981852166 cites W2078066159 @default.
• W2981852166 cites W2079211255 @default.
• W2981852166 cites W2080844332 @default.
• W2981852166 cites W2082363650 @default.
• W2981852166 cites W2082846705 @default.
• W2981852166 cites W2083875067 @default.
• W2981852166 cites W2084470691 @default.
• W2981852166 cites W2088224739 @default.
• W2981852166 cites W2088412514 @default.
• W2981852166 cites W2090123613 @default.
• W2981852166 cites W2091427755 @default.
• W2981852166 cites W2091987454 @default.
• W2981852166 cites W2093206323 @default.
• W2981852166 cites W2095404464 @default.
• W2981852166 cites W2098247759 @default.
• W2981852166 cites W2099325760 @default.
• W2981852166 cites W2102147647 @default.
• W2981852166 cites W2106502827 @default.
• W2981852166 cites W2108279958 @default.

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