FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981931115> ?p ?o ?g. }

• W2981931115 endingPage "1954.e1" @default.
• W2981931115 startingPage "1939" @default.
• W2981931115 abstract "PurposeCoccidioidomycosis (CM) is a systemic fungal disease caused by the dimorphic fungi Coccidioides immitis and Coccidioides posadasii. In its endemic areas of the United States, CM is growing as a public health challenge with a marked increase in incidence in the last 15 years. Although Coccidioides infection is asymptomatic in most cases, symptomatic pulmonary disease occurs in ~40% and disseminated coccidioidomycosis (DCM) occurs in ~1% of previously healthy children and adults. DCM is markedly more common in immunocompromised people, who often experience life-threatening disease despite use of antifungal medications. Although options for antifungal therapy have improved, lifelong therapy is needed for those who develop coccidioidal meningitis. The purpose of this article was to review the state of antifungal therapy and recent studies of host–pathogen interactions in CM in light of advances in immunomodulatory therapy.MethodsThe study included a review of PubMed and abstracts of the Coccidioidomycosis Study Group (years 2000–2019).FindingsCurrent therapy for CM relies upon azole and polyene antifungal agents. Murine models and studies of DCM in patients with monogenic primary immunodeficiency states and acquired immunodeficiency have revealed the importance of both innate and adaptive immune responses in the control of infections with Coccidioides species. In particular, defects in sensing of fungi and induction of cellular immune responses have been frequently reported. More recently, polymorphisms in key signaling pathways and in the generation of Th17 and Th1 immune responses have been linked with DCM.ImplicationsAntifungal therapy is sufficient to control disease in most cases of CM, but treatment failure occurs in cases of severe pulmonary disease and nonmeningeal disseminated disease. Lifelong therapy is recommended for meningitis in view of the very high risk of recurrence. Corticosteroid therapy is advised by some experts for severe pulmonary disease and for some neurologic complications of DCM. DCM is only rarely the result of a severe monogenic immunodeficiency. Case studies suggest that reorienting cellular immune responses or augmenting effector immune responses may help resolve DCM. Systematic investigation of immunotherapy for coccidioidomycosis is advisable and may help to address the recent marked increase in reports of the disease in endemic areas." @default.
• W2981931115 created "2019-11-01" @default.
• W2981931115 creator A5049464065 @default.
• W2981931115 creator A5057600781 @default.
• W2981931115 creator A5058131118 @default.
• W2981931115 creator A5061866121 @default.
• W2981931115 creator A5083542791 @default.
• W2981931115 date "2019-10-01" @default.
• W2981931115 modified "2023-10-18" @default.
• W2981931115 title "Host–Pathogen Interactions in Coccidioidomycosis: Prognostic Clues and Opportunities for Novel Therapies" @default.
• W2981931115 cites W1493978345 @default.
• W2981931115 cites W1585310840 @default.
• W2981931115 cites W1891900368 @default.
• W2981931115 cites W1942910567 @default.
• W2981931115 cites W1945479327 @default.
• W2981931115 cites W1965088264 @default.
• W2981931115 cites W1967879315 @default.
• W2981931115 cites W1971938790 @default.
• W2981931115 cites W1982029015 @default.
• W2981931115 cites W1986228855 @default.
• W2981931115 cites W1989862062 @default.
• W2981931115 cites W2000962240 @default.
• W2981931115 cites W2006787162 @default.
• W2981931115 cites W2018260167 @default.
• W2981931115 cites W2024956017 @default.
• W2981931115 cites W2034453891 @default.
• W2981931115 cites W2036325031 @default.
• W2981931115 cites W2049570643 @default.
• W2981931115 cites W2050443037 @default.
• W2981931115 cites W2062615096 @default.
• W2981931115 cites W2065617514 @default.
• W2981931115 cites W2065870824 @default.
• W2981931115 cites W2072035928 @default.
• W2981931115 cites W2073330059 @default.
• W2981931115 cites W2077223232 @default.
• W2981931115 cites W2078710724 @default.
• W2981931115 cites W2083305942 @default.
• W2981931115 cites W2083986481 @default.
• W2981931115 cites W2087166943 @default.
• W2981931115 cites W2087302450 @default.
• W2981931115 cites W2092155187 @default.
• W2981931115 cites W2094511280 @default.
• W2981931115 cites W2095908511 @default.
• W2981931115 cites W2095949142 @default.
• W2981931115 cites W2097047416 @default.
• W2981931115 cites W2101524137 @default.
• W2981931115 cites W2102705829 @default.
• W2981931115 cites W2104866075 @default.
• W2981931115 cites W2108822061 @default.
• W2981931115 cites W2115055179 @default.
• W2981931115 cites W2115160403 @default.
• W2981931115 cites W2117227516 @default.
• W2981931115 cites W2117613919 @default.
• W2981931115 cites W2121842229 @default.
• W2981931115 cites W2124070047 @default.
• W2981931115 cites W2127379211 @default.
• W2981931115 cites W2127573804 @default.
• W2981931115 cites W2129525280 @default.
• W2981931115 cites W2131843801 @default.
• W2981931115 cites W2134194869 @default.
• W2981931115 cites W2139270181 @default.
• W2981931115 cites W2140878721 @default.
• W2981931115 cites W2141954685 @default.
• W2981931115 cites W2142323168 @default.
• W2981931115 cites W2142602093 @default.
• W2981931115 cites W2143043043 @default.
• W2981931115 cites W2145709723 @default.
• W2981931115 cites W2146171603 @default.
• W2981931115 cites W2153555681 @default.
• W2981931115 cites W2163045217 @default.
• W2981931115 cites W2164500783 @default.
• W2981931115 cites W2195029035 @default.
• W2981931115 cites W2256016639 @default.
• W2981931115 cites W2278894526 @default.
• W2981931115 cites W2288985240 @default.
• W2981931115 cites W2304870262 @default.
• W2981931115 cites W2479157738 @default.
• W2981931115 cites W2577734894 @default.
• W2981931115 cites W2593361114 @default.
• W2981931115 cites W2620124785 @default.
• W2981931115 cites W2726385984 @default.
• W2981931115 cites W2790128953 @default.
• W2981931115 cites W2791659277 @default.
• W2981931115 cites W2797072558 @default.
• W2981931115 cites W2803941918 @default.
• W2981931115 cites W2804510602 @default.
• W2981931115 cites W2805002966 @default.
• W2981931115 cites W2888112997 @default.
• W2981931115 cites W2889920983 @default.
• W2981931115 cites W2895559790 @default.
• W2981931115 cites W2901594906 @default.
• W2981931115 cites W2905452503 @default.
• W2981931115 cites W2911397280 @default.
• W2981931115 cites W2911630318 @default.
• W2981931115 cites W2913091535 @default.
• W2981931115 cites W2913854605 @default.
• W2981931115 cites W2944537735 @default.
• W2981931115 cites W4242945259 @default.

• next