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• W2981958620 abstract "Ebola virus (EBOV) infections are characterized by a pronounced lymphopenia that is highly correlative with fatalities. However, the mechanisms leading to T-cell depletion remain largely unknown. Here, we demonstrate that both viral mRNAs and antigens are detectable in CD4+ T cells despite the absence of productive infection. A protein phosphatase 1 inhibitor, 1E7-03, and siRNA-mediated suppression of viral antigens were used to demonstrate de novo synthesis of viral RNAs and antigens in CD4+ T cells, respectively. Cell-to-cell fusion of permissive Huh7 cells with non-permissive Jurkat T cells impaired productive EBOV infection suggesting the presence of a cellular restriction factor. We determined that viral transcription is partially impaired in the fusion T cells. Lastly, we demonstrate that exposure of T cells to EBOV resulted in autophagy through activation of ER-stress related pathways. These data indicate that exposure of T cells to EBOV results in an abortive infection, which likely contributes to the lymphopenia observed during EBOV infections." @default.
• W2981958620 created "2019-11-01" @default.
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• W2981958620 date "2019-10-24" @default.
• W2981958620 modified "2023-10-10" @default.
• W2981958620 title "Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection" @default.
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• W2981958620 doi "https://doi.org/10.1371/journal.ppat.1008068" @default.
• W2981958620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6812753" @default.
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