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- W2981970793 abstract "Because national datasets do not collect relevant data, few studies have analyzed the timing, sites, and correlates of lung cancer recurrence. We therefore employed an institutional tumor registry to obtain information on this critical, intermediary disease outcome. From the UT Southwestern Tumor Registry, we identified cases or primary and/or recurrent lung cancer diagnosed January 1, 2000, to December 31, 2017. For cases with recurrent disease, we recorded site, timing, and case characteristics (including gender, age, race, histology, and primary treatment). Associations between these factors were evaluated using univariable and multivariable random-effect logistic regression models. We estimated time to recurrence using Kaplan-Meier methods. We used univariable and multivariable marginal Cox regression models were to assess the association between time to recurrence and case characteristics. A total of 1,619 stage 1-3 lung cancer cases from 1,549 patients were analyzed. Of these, 466 patients (30%) had recurrent lung cancer. In multivariable analyses, both race (P=0.02) and primary treatment (P<0.001) significantly correlated with recurrence. Among recurrent cases, patient age (P=0.02) and TNM staging (P=0.001) significantly correlated with timing of recurrence. The most common type of first recurrence was distant disease, most frequently central nervous system (94/162, 58%). The development of distant recurrent disease was associated with race (P=0.01), histology (P=0.004), and primary treatment (P=0.03). In this single-center analysis of early stage and locally advanced in lung cancer, approximately one-third of cases develop recurrent disease, most commonly at distant metastatic sites. Central nervous system was the most frequent site of distant recurrence, accounting for more than half of cases. Race, TNM stage, and primary treatment were associated with the timing and site of recurrent disease. These findings have potential relevance to post-treatment clinical and radiographic surveillance." @default.
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- W2981970793 date "2019-10-01" @default.
- W2981970793 modified "2023-09-30" @default.
- W2981970793 title "P1.16-41 Timing, Sites, and Correlates of Lung Cancer Recurrence: The Missing Pieces in National Datasets" @default.
- W2981970793 doi "https://doi.org/10.1016/j.jtho.2019.08.1267" @default.
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