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- W2982007054 abstract "The mammalian heart loses the ability to regenerate within the first few days after birth. Myocardial injury in the adult heart leads to an irreversible loss of vital myocardium and often results in heart failure. Current heart failure pharmacotherapy has reduced mortality considerably over the last few decades but it does not induce the formation of new myocardium. Cardiac regeneration is a highly ambitious goal but there are now three strategies that have consistently demonstrated a potential to provide new myocytes to the injured heart in preclinical models: Cardiomyocyte transplantation, stimulation of cardiomyocyte proliferation and direct reprogramming of non-myocytes to cardiomyocytes. This brief review presents these three strategies and discusses the current state from small animal models to clinical trials." @default.
- W2982007054 created "2019-11-01" @default.
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- W2982007054 date "2020-04-01" @default.
- W2982007054 modified "2023-09-26" @default.
- W2982007054 title "Heart regeneration: from mouse to human" @default.
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- W2982007054 doi "https://doi.org/10.1016/j.cophys.2019.10.010" @default.
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