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• W2982022308 abstract "Small cell lung cancer (SCLC) is a very aggressive type of lung cancer. Due to this behavior, it presents early development of metastases. Brain metastases (BM) are very common and are related with a great impact on both survival and quality of life. Prophylactic cranial irradiation (PCI) is used for patients without detectable brain metastases, improving survival and decreasing the incidence of brain relapses (BR). Cranial irradiation (CI) for affected patients are usually used in patients with clinical BM, but its benefits are less clear. We conducted a descriptive and retrospective study including all patients diagnosed with SCLC tumor between January 2012 and December 2018 (both localized and metastatic). We study the impact of PCI and CI in both patients with/without BM at diagnosis. A Kaplan Meier survival analysis (log-rank analysis) was carried out to study the overall survival and the impact of the radiotherapy treatment. Of the 98 patients included, 60.2% presents extensive-stage, while 39% were locally advanced. Of the advanced stages, only 18.4% presented brain involvement at the diagnosis. 34.7% of the patients received RT at the diagnosis (37.5% PCI and 50% of the patients with BM received CI). Over the course of the disease, 35.1% of the patients present BR. 67.6% of the patients treated with RT at diagnosis (both PCI and CI) relapsed in the brain, meanwhile, the 54.8% in the group without RT (no significant differences). However, in the RT group, 69.5% of patients relapse outside the brain (mainly the lung). Chemosensitive didn't show any relation with the incidence of BR (30.4% RT group vs. 35.7% in no-RT group). Overall, there were no significant differences in survival (p 0.19) between the group treated with RT (both PCI and CI) and the group which didn't. SCLC presents early dissemination. Brain is one of the main organs involved. PCI for patients without detectable BM decrease the incidence of brain relapses and improve survival. The impact of CI is less clear in patients that already have BM. Surprisingly, in our series, we didn't find any difference with PCI or CI in overall survival and BR. A high proportion of the patients in both groups (with/without BM at diagnosis) didn't receive radiotherapy, due to a very poor clinical status (which can may lead to bias). More studies will be needed to be able to clarify the prognostic impact of these metastases and the effectiveness of this treatment nowadays." @default.
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• W2982022308 date "2019-10-01" @default.
• W2982022308 modified "2023-09-26" @default.
• W2982022308 title "EP1.12-26 Retrospective Study About the Impact of Brain Metastases and Cranial Irradiation in Small Cell Lung Cancer" @default.
• W2982022308 doi "https://doi.org/10.1016/j.jtho.2019.08.2271" @default.
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