FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982023912> ?p ?o ?g. }

• W2982023912 endingPage "1793" @default.
• W2982023912 startingPage "1793" @default.
• W2982023912 abstract "Background: Glucose-regulated protein 78/Binding immunoglobulin protein (GRP78/BiP) is a protein associated with endoplasmic reticulum stress and is upregulated by metabolic alterations at the tissue-level, such as hypoxia or glucose deprivation, and it is hyper-expressed in fat tissue of obese individuals. Objective: To investigate the role of the GRP78/BiP level as a metabolic and vascular disease biomarker in patients with type 2 diabetes (DM), obesity and metabolic syndrome (MS). Methods: Four hundred and five patients were recruited, of whom 52.5% were obese, 72.8% had DM, and 78.6% had MS. The intimae media thickness (cIMT) was assessed by ultrasonography. The plasma GRP78/BiP concentration was determined, and its association with metabolic and vascular parameters was assessed. Circulating GRP78/BiP was also prospectively measured in 30 DM patients before and after fenofibrate/niacin treatment and 30 healthy controls. Results: In the cross-sectional study, the GRP78/BiP level was significantly higher in the patients with obesity, DM, and MS. Age-, gender- and BMI-adjusted GRP78/BiP was directly associated with LDL-cholesterol, non-HDL-cholesterol, triglycerides, apoB, and cIMT. GRP78/BiP was positively associated to carotid plaque presence in the adjusted model, irrespective of obesity, DM and MS. In the prospective study, nicotinic acid treatment produced a significant reduction in the GRP78/BiP levels that was not observed with fenofibrate. Conclusions: GRP78/BiP plasma concentrations are increased in patients with both metabolic derangements and subclinical atherosclerosis. GRP78/BiP could be a useful marker of metabolic and cardiovascular risk." @default.
• W2982023912 created "2019-11-01" @default.
• W2982023912 creator A5003907607 @default.
• W2982023912 creator A5020529537 @default.
• W2982023912 creator A5037440569 @default.
• W2982023912 creator A5040190129 @default.
• W2982023912 creator A5048724654 @default.
• W2982023912 creator A5048865471 @default.
• W2982023912 creator A5057374991 @default.
• W2982023912 creator A5060752196 @default.
• W2982023912 creator A5071468133 @default.
• W2982023912 creator A5082478161 @default.
• W2982023912 creator A5083733947 @default.
• W2982023912 date "2019-10-26" @default.
• W2982023912 modified "2023-10-12" @default.
• W2982023912 title "The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario" @default.
• W2982023912 cites W1537625894 @default.
• W2982023912 cites W1995483143 @default.
• W2982023912 cites W2002349652 @default.
• W2982023912 cites W2005646330 @default.
• W2982023912 cites W2007078899 @default.
• W2982023912 cites W2019111347 @default.
• W2982023912 cites W2023975386 @default.
• W2982023912 cites W2027495820 @default.
• W2982023912 cites W2048456744 @default.
• W2982023912 cites W2051236743 @default.
• W2982023912 cites W2054558339 @default.
• W2982023912 cites W2065720808 @default.
• W2982023912 cites W2066898102 @default.
• W2982023912 cites W2072671396 @default.
• W2982023912 cites W2079643102 @default.
• W2982023912 cites W2084518640 @default.
• W2982023912 cites W2122631753 @default.
• W2982023912 cites W2130120054 @default.
• W2982023912 cites W2132759134 @default.
• W2982023912 cites W2145029154 @default.
• W2982023912 cites W2147127785 @default.
• W2982023912 cites W2161939149 @default.
• W2982023912 cites W2165266278 @default.
• W2982023912 cites W2345368448 @default.
• W2982023912 cites W2412254482 @default.
• W2982023912 cites W2469797279 @default.
• W2982023912 cites W2495672790 @default.
• W2982023912 cites W2550930826 @default.
• W2982023912 cites W2588958678 @default.
• W2982023912 cites W2593099486 @default.
• W2982023912 cites W2611138906 @default.
• W2982023912 cites W2904223696 @default.
• W2982023912 cites W2915624492 @default.
• W2982023912 doi "https://doi.org/10.3390/jcm8111793" @default.
• W2982023912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6912434" @default.
• W2982023912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31717752" @default.
• W2982023912 hasPublicationYear "2019" @default.
• W2982023912 type Work @default.
• W2982023912 sameAs 2982023912 @default.
• W2982023912 citedByCount "34" @default.
• W2982023912 countsByYear W29820239122020 @default.
• W2982023912 countsByYear W29820239122021 @default.
• W2982023912 countsByYear W29820239122022 @default.
• W2982023912 countsByYear W29820239122023 @default.
• W2982023912 crossrefType "journal-article" @default.
• W2982023912 hasAuthorship W2982023912A5003907607 @default.
• W2982023912 hasAuthorship W2982023912A5020529537 @default.
• W2982023912 hasAuthorship W2982023912A5037440569 @default.
• W2982023912 hasAuthorship W2982023912A5040190129 @default.
• W2982023912 hasAuthorship W2982023912A5048724654 @default.
• W2982023912 hasAuthorship W2982023912A5048865471 @default.
• W2982023912 hasAuthorship W2982023912A5057374991 @default.
• W2982023912 hasAuthorship W2982023912A5060752196 @default.
• W2982023912 hasAuthorship W2982023912A5071468133 @default.
• W2982023912 hasAuthorship W2982023912A5082478161 @default.
• W2982023912 hasAuthorship W2982023912A5083733947 @default.
• W2982023912 hasBestOaLocation W29820239121 @default.
• W2982023912 hasConcept C126322002 @default.
• W2982023912 hasConcept C134018914 @default.
• W2982023912 hasConcept C139447449 @default.
• W2982023912 hasConcept C158617107 @default.
• W2982023912 hasConcept C171089720 @default.
• W2982023912 hasConcept C2778110834 @default.
• W2982023912 hasConcept C2778163477 @default.
• W2982023912 hasConcept C2780578515 @default.
• W2982023912 hasConcept C2781197716 @default.
• W2982023912 hasConcept C511355011 @default.
• W2982023912 hasConcept C55493867 @default.
• W2982023912 hasConcept C555293320 @default.
• W2982023912 hasConcept C62746215 @default.
• W2982023912 hasConcept C71924100 @default.
• W2982023912 hasConcept C86803240 @default.
• W2982023912 hasConceptScore W2982023912C126322002 @default.
• W2982023912 hasConceptScore W2982023912C134018914 @default.
• W2982023912 hasConceptScore W2982023912C139447449 @default.
• W2982023912 hasConceptScore W2982023912C158617107 @default.
• W2982023912 hasConceptScore W2982023912C171089720 @default.
• W2982023912 hasConceptScore W2982023912C2778110834 @default.
• W2982023912 hasConceptScore W2982023912C2778163477 @default.
• W2982023912 hasConceptScore W2982023912C2780578515 @default.
• W2982023912 hasConceptScore W2982023912C2781197716 @default.
• W2982023912 hasConceptScore W2982023912C511355011 @default.

• next