FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982029976> ?p ?o ?g. }

• W2982029976 endingPage "68" @default.
• W2982029976 startingPage "61" @default.
• W2982029976 abstract "Sensitive and reliable detection of biomarkers is of vital importance in tumor early detection and clinical therapy. A novel fluorescent/electrochemical dual-responsive immunosensing platform for reliable and sensitive quantification of biomarkers was designed based on cation-exchange reaction. To construct such a versatile platform, the model analyte, carcinoembryonic antigen (CEA), was captured by magnetic Fe3O4 nanoparticles bound with primary antibodies (Fe3O4-Ab1) and then recognized by the detection antibodies conjugated complex containing poly(amidoamine) (PAMAM), carbon nanotube (CNT) and carboxyl functionalized CdSe nanocrystals (NCs) (CNT-PAMAM-CdSe NCs-Ab2). Via ligand exchange, the stable CdSe nanocrystals were easily functionalized with carboxylate ion (CdSe–COO-) and showed high hydrophilicity. The CdSe–COO- was effectively and densely conjugated to CNT coated dendrimer PAMAM that possesses large specific surface area. Finally, the target CEA was detected based on cation-exchange reaction (CER) by adding Ag+ to release thousands of cations Cd2+, which were detected by fluorescence and electrochemistry simultaneously. The electrochemical measurement was performed by directly detecting Cd2+ through square wave voltammetry (SWV), which displayed an excellent correlation with CEA from 5 pg/mL to 50 ng/mL, with a limit of detection (LOD) of 1.7 pg/mL. The fluorescence detection was implemented since free Cd2+ could trigger the weak fluorescence metal-sensitive dyes (Rhod-5N) to generate extremely high fluorescence signal. The fluorescence results showed the LOD for CEA detection was 0.25 pg/mL with a calibration curve range from 1 pg/mL to 20 ng/mL. The dual signal outputs showed an attractively self-correcting ability, which provides the capability of avoiding false positive signal and making the detection result more reliable. The proposed dual-responsive platform holds great promises for biomarkers detection in clinical diagnostics and therapy." @default.
• W2982029976 created "2019-11-01" @default.
• W2982029976 creator A5033880878 @default.
• W2982029976 creator A5041255737 @default.
• W2982029976 creator A5064925036 @default.
• W2982029976 creator A5072033890 @default.
• W2982029976 creator A5079462468 @default.
• W2982029976 date "2020-02-01" @default.
• W2982029976 modified "2023-10-13" @default.
• W2982029976 title "A novel fluorescent and electrochemical dual-responsive immunosensor for sensitive and reliable detection of biomarkers based on cation-exchange reaction" @default.
• W2982029976 cites W1967870961 @default.
• W2982029976 cites W1978552755 @default.
• W2982029976 cites W1987823501 @default.
• W2982029976 cites W1996226687 @default.
• W2982029976 cites W1998798412 @default.
• W2982029976 cites W1999998886 @default.
• W2982029976 cites W2007941671 @default.
• W2982029976 cites W2012036400 @default.
• W2982029976 cites W2030003470 @default.
• W2982029976 cites W2034753500 @default.
• W2982029976 cites W2042237866 @default.
• W2982029976 cites W2080038832 @default.
• W2982029976 cites W2080445357 @default.
• W2982029976 cites W2084577309 @default.
• W2982029976 cites W2096933592 @default.
• W2982029976 cites W211236473 @default.
• W2982029976 cites W2151326298 @default.
• W2982029976 cites W2163905114 @default.
• W2982029976 cites W2164379291 @default.
• W2982029976 cites W2228424836 @default.
• W2982029976 cites W2253960332 @default.
• W2982029976 cites W2291148519 @default.
• W2982029976 cites W2326135545 @default.
• W2982029976 cites W2326753855 @default.
• W2982029976 cites W2331178321 @default.
• W2982029976 cites W2341239587 @default.
• W2982029976 cites W2346031875 @default.
• W2982029976 cites W2401032979 @default.
• W2982029976 cites W2466400034 @default.
• W2982029976 cites W2511265173 @default.
• W2982029976 cites W2540842026 @default.
• W2982029976 cites W2555955413 @default.
• W2982029976 cites W2564904876 @default.
• W2982029976 cites W2587147978 @default.
• W2982029976 cites W2749999154 @default.
• W2982029976 cites W2752842643 @default.
• W2982029976 cites W2754888728 @default.
• W2982029976 cites W2765206360 @default.
• W2982029976 cites W2776358573 @default.
• W2982029976 cites W2777103595 @default.
• W2982029976 cites W2783130761 @default.
• W2982029976 doi "https://doi.org/10.1016/j.aca.2019.10.054" @default.
• W2982029976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31883592" @default.
• W2982029976 hasPublicationYear "2020" @default.
• W2982029976 type Work @default.
• W2982029976 sameAs 2982029976 @default.
• W2982029976 citedByCount "22" @default.
• W2982029976 countsByYear W29820299762020 @default.
• W2982029976 countsByYear W29820299762021 @default.
• W2982029976 countsByYear W29820299762022 @default.
• W2982029976 countsByYear W29820299762023 @default.
• W2982029976 crossrefType "journal-article" @default.
• W2982029976 hasAuthorship W2982029976A5033880878 @default.
• W2982029976 hasAuthorship W2982029976A5041255737 @default.
• W2982029976 hasAuthorship W2982029976A5064925036 @default.
• W2982029976 hasAuthorship W2982029976A5072033890 @default.
• W2982029976 hasAuthorship W2982029976A5079462468 @default.
• W2982029976 hasConcept C10349863 @default.
• W2982029976 hasConcept C10390740 @default.
• W2982029976 hasConcept C112613896 @default.
• W2982029976 hasConcept C119128265 @default.
• W2982029976 hasConcept C121332964 @default.
• W2982029976 hasConcept C147789679 @default.
• W2982029976 hasConcept C155672457 @default.
• W2982029976 hasConcept C171250308 @default.
• W2982029976 hasConcept C17525397 @default.
• W2982029976 hasConcept C178790620 @default.
• W2982029976 hasConcept C185592680 @default.
• W2982029976 hasConcept C188027245 @default.
• W2982029976 hasConcept C192562407 @default.
• W2982029976 hasConcept C21951064 @default.
• W2982029976 hasConcept C23531484 @default.
• W2982029976 hasConcept C43617362 @default.
• W2982029976 hasConcept C521977710 @default.
• W2982029976 hasConcept C52859227 @default.
• W2982029976 hasConcept C55637122 @default.
• W2982029976 hasConcept C62520636 @default.
• W2982029976 hasConcept C91881484 @default.
• W2982029976 hasConceptScore W2982029976C10349863 @default.
• W2982029976 hasConceptScore W2982029976C10390740 @default.
• W2982029976 hasConceptScore W2982029976C112613896 @default.
• W2982029976 hasConceptScore W2982029976C119128265 @default.
• W2982029976 hasConceptScore W2982029976C121332964 @default.
• W2982029976 hasConceptScore W2982029976C147789679 @default.
• W2982029976 hasConceptScore W2982029976C155672457 @default.
• W2982029976 hasConceptScore W2982029976C171250308 @default.
• W2982029976 hasConceptScore W2982029976C17525397 @default.
• W2982029976 hasConceptScore W2982029976C178790620 @default.

• next