FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982034240> ?p ?o ?g. }

• W2982034240 abstract "Abstract Abstract Background Mechanistic features of functional mitral regurgitation (FMR) include papillary muscle displacement due to left ventricular remodeling. Intraventricular conduction delay might further augment this condition by introducing interpapillary muscle dyssynchrony. Objectives To define this mechanism as a major contributing factor in FMR and prove the reversibility of FMR by interpapillary muscle resynchronization. Methods We enrolled 269 chronic HFrEF patients with conduction delay and comprehensively assessed dyssynchrony by complementary echocardiographic techniques. Opposing wall delay, calculated by speckle tracking, was determined as the time difference between peak longitudinal strain of the mid-anterior and inferior wall from a 2-chamber view. Furthermore, opposing wall delay was assessed as the time difference between peak strain values from tissue Doppler velocity-coded data of the mid-inferior septal and mid-lateral wall segments. Results Patients with severe FMR had markedly increased interpapillary longitudinal dyssynchrony (160ms [IQR 120–200]) compared to those with moderate (70ms [IQR 40–110]), no, or mild FMR (60ms [IQR 30–100]; P<0.001). Increased interpapillary muscle dyssynchrony was correlated with effective regurgitant orifice area (P<0.001; Figure A), regurgitant volume (P<0.001, Figure B) and vena contracta width (P<0.001, Figure C). Restoration of longitudinal papillary muscle synchronicity by cardiac resynchronization therapy (CRT) was correlated with FMR regression, as reflected by the reduction in regurgitant volume (P<0.001) and vena contracta width (P<0.001). Conversely, the improvement of FMR was associated with improved interpapillary radial (P=0.006) and longitudinal (P<0.001) dyssynchrony. The improvement of dyssynchrony-mediated FMR signified a better prognosis compared to no improvement in FMR during the 8-year follow-up period even after comprehensive adjustment by a bootstrap-selected confounder model (adj. HR of 0.41; 95% CI 0.18–0.91; P=0.028; Figure D). The results remained virtually unchanged after adjustment for left bundle branch block. Figure 1. Dyssynchrony-FMR-CRT Conclusion Intraventricular dyssynchrony introduces unequal contraction by papillary muscle bearing walls, which has an adverse effect on FMR. CRT can effectively restore interpapillary balance and thus create a less tented leaflet configuration, resulting in a clinically meaningful reduction of FMR. The restoration of papillary muscle synchronicity in dyssynchrony-mediated FMR translates into a significantly better prognosis." @default.
• W2982034240 created "2019-11-01" @default.
• W2982034240 creator A5007828638 @default.
• W2982034240 creator A5015025542 @default.
• W2982034240 creator A5019910434 @default.
• W2982034240 creator A5029331602 @default.
• W2982034240 creator A5036815239 @default.
• W2982034240 creator A5043259514 @default.
• W2982034240 creator A5047582552 @default.
• W2982034240 creator A5055334753 @default.
• W2982034240 creator A5068862747 @default.
• W2982034240 creator A5074344007 @default.
• W2982034240 date "2019-10-01" @default.
• W2982034240 modified "2023-09-23" @default.
• W2982034240 title "5943Mechanistic insights of papillary muscle dyssynchrony mediated function mitral regurgitation and modulation by cardiac resynchronization" @default.
• W2982034240 doi "https://doi.org/10.1093/eurheartj/ehz746.0093" @default.
• W2982034240 hasPublicationYear "2019" @default.
• W2982034240 type Work @default.
• W2982034240 sameAs 2982034240 @default.
• W2982034240 citedByCount "0" @default.
• W2982034240 crossrefType "journal-article" @default.
• W2982034240 hasAuthorship W2982034240A5007828638 @default.
• W2982034240 hasAuthorship W2982034240A5015025542 @default.
• W2982034240 hasAuthorship W2982034240A5019910434 @default.
• W2982034240 hasAuthorship W2982034240A5029331602 @default.
• W2982034240 hasAuthorship W2982034240A5036815239 @default.
• W2982034240 hasAuthorship W2982034240A5043259514 @default.
• W2982034240 hasAuthorship W2982034240A5047582552 @default.
• W2982034240 hasAuthorship W2982034240A5055334753 @default.
• W2982034240 hasAuthorship W2982034240A5068862747 @default.
• W2982034240 hasAuthorship W2982034240A5074344007 @default.
• W2982034240 hasConcept C126322002 @default.
• W2982034240 hasConcept C164705383 @default.
• W2982034240 hasConcept C2776034619 @default.
• W2982034240 hasConcept C2776720267 @default.
• W2982034240 hasConcept C2777274916 @default.
• W2982034240 hasConcept C2778198053 @default.
• W2982034240 hasConcept C2909944400 @default.
• W2982034240 hasConcept C2993373945 @default.
• W2982034240 hasConcept C71924100 @default.
• W2982034240 hasConcept C78085059 @default.
• W2982034240 hasConceptScore W2982034240C126322002 @default.
• W2982034240 hasConceptScore W2982034240C164705383 @default.
• W2982034240 hasConceptScore W2982034240C2776034619 @default.
• W2982034240 hasConceptScore W2982034240C2776720267 @default.
• W2982034240 hasConceptScore W2982034240C2777274916 @default.
• W2982034240 hasConceptScore W2982034240C2778198053 @default.
• W2982034240 hasConceptScore W2982034240C2909944400 @default.
• W2982034240 hasConceptScore W2982034240C2993373945 @default.
• W2982034240 hasConceptScore W2982034240C71924100 @default.
• W2982034240 hasConceptScore W2982034240C78085059 @default.
• W2982034240 hasLocation W29820342401 @default.
• W2982034240 hasOpenAccess W2982034240 @default.
• W2982034240 hasPrimaryLocation W29820342401 @default.
• W2982034240 hasRelatedWork W1592913821 @default.
• W2982034240 hasRelatedWork W1971229409 @default.
• W2982034240 hasRelatedWork W1988995152 @default.
• W2982034240 hasRelatedWork W2013164041 @default.
• W2982034240 hasRelatedWork W2026686673 @default.
• W2982034240 hasRelatedWork W2141508989 @default.
• W2982034240 hasRelatedWork W2409332912 @default.
• W2982034240 hasRelatedWork W2416046434 @default.
• W2982034240 hasRelatedWork W2524762240 @default.
• W2982034240 hasRelatedWork W2526593827 @default.
• W2982034240 hasRelatedWork W2600774753 @default.
• W2982034240 hasRelatedWork W2631900313 @default.
• W2982034240 hasRelatedWork W2733185222 @default.
• W2982034240 hasRelatedWork W2803368981 @default.
• W2982034240 hasRelatedWork W2890588865 @default.
• W2982034240 hasRelatedWork W2906640079 @default.
• W2982034240 hasRelatedWork W3206435773 @default.
• W2982034240 hasRelatedWork W892256 @default.
• W2982034240 hasRelatedWork W2299855600 @default.
• W2982034240 hasRelatedWork W2490392047 @default.
• W2982034240 isParatext "false" @default.
• W2982034240 isRetracted "false" @default.
• W2982034240 magId "2982034240" @default.
• W2982034240 workType "article" @default.