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- W2982046601 abstract "Abstract Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental disorders such as Fragile X Syndrome (FXS). How developmental changes in neuronal function culminate in network dysfunction that underlies sensory hypersensitivities is unknown. By systematically studying cellular and synaptic properties of layer 4 neurons combined with cellular and network simulations, we explored how the array of phenotypes in Fmr1 -knockout (KO) mice produce circuit pathology during development. We show that many of the cellular and synaptic pathologies in Fmr1 - KO mice are antagonistic, mitigating circuit dysfunction, and hence may be compensatory to the primary pathology. Overall, the layer 4 network in the Fmr1 - KO exhibits significant alterations in spike output in response to thalamocortical input and distorted sensory encoding. This developmental loss of layer 4 sensory encoding precision would contribute to subsequent developmental alterations in layer 4-to-layer 2/3 connectivity and plasticity observed in Fmr1-KO mice, and circuit dysfunction underlying sensory hypersensitivity." @default.
- W2982046601 created "2019-11-01" @default.
- W2982046601 creator A5029309237 @default.
- W2982046601 creator A5029749100 @default.
- W2982046601 creator A5043175575 @default.
- W2982046601 creator A5081949745 @default.
- W2982046601 creator A5084280682 @default.
- W2982046601 date "2019-10-23" @default.
- W2982046601 modified "2023-10-15" @default.
- W2982046601 title "Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex" @default.
- W2982046601 cites W1486735428 @default.
- W2982046601 cites W1512427594 @default.
- W2982046601 cites W1530038420 @default.
- W2982046601 cites W1540069135 @default.
- W2982046601 cites W1578017152 @default.
- W2982046601 cites W1581532160 @default.
- W2982046601 cites W1613369435 @default.
- W2982046601 cites W1621052465 @default.
- W2982046601 cites W1911320126 @default.
- W2982046601 cites W1940417817 @default.
- W2982046601 cites W1964470295 @default.
- W2982046601 cites W1966371094 @default.
- W2982046601 cites W1979617279 @default.
- W2982046601 cites W1980455223 @default.
- W2982046601 cites W1984618862 @default.
- W2982046601 cites W1990515322 @default.
- W2982046601 cites W1992594858 @default.
- W2982046601 cites W1998681647 @default.
- W2982046601 cites W2001630282 @default.
- W2982046601 cites W2002404172 @default.
- W2982046601 cites W2002648463 @default.
- W2982046601 cites W2006079595 @default.
- W2982046601 cites W2010975466 @default.
- W2982046601 cites W2011316391 @default.
- W2982046601 cites W2018085295 @default.
- W2982046601 cites W2020352503 @default.
- W2982046601 cites W2026520221 @default.
- W2982046601 cites W2028399966 @default.
- W2982046601 cites W2032131334 @default.
- W2982046601 cites W2034108533 @default.
- W2982046601 cites W2034460847 @default.
- W2982046601 cites W2041544548 @default.
- W2982046601 cites W2041746311 @default.
- W2982046601 cites W2044182049 @default.
- W2982046601 cites W2044202654 @default.
- W2982046601 cites W2045203721 @default.
- W2982046601 cites W2047157737 @default.
- W2982046601 cites W2047405616 @default.
- W2982046601 cites W2050643127 @default.
- W2982046601 cites W2051721197 @default.
- W2982046601 cites W2052326665 @default.
- W2982046601 cites W2066185760 @default.
- W2982046601 cites W2066218718 @default.
- W2982046601 cites W2067485452 @default.
- W2982046601 cites W2067501282 @default.
- W2982046601 cites W2068181401 @default.
- W2982046601 cites W2070472892 @default.
- W2982046601 cites W2071366993 @default.
- W2982046601 cites W2072652550 @default.
- W2982046601 cites W2074298224 @default.
- W2982046601 cites W2074376560 @default.
- W2982046601 cites W2078544102 @default.
- W2982046601 cites W2081857442 @default.
- W2982046601 cites W2087965324 @default.
- W2982046601 cites W2094359469 @default.
- W2982046601 cites W2096270532 @default.
- W2982046601 cites W2098756736 @default.
- W2982046601 cites W2099525751 @default.
- W2982046601 cites W2100212553 @default.
- W2982046601 cites W2102450342 @default.
- W2982046601 cites W2103081445 @default.
- W2982046601 cites W2105464873 @default.
- W2982046601 cites W2108470366 @default.
- W2982046601 cites W2109062476 @default.
- W2982046601 cites W2110811750 @default.
- W2982046601 cites W2111128547 @default.
- W2982046601 cites W2111562869 @default.
- W2982046601 cites W2112137180 @default.
- W2982046601 cites W2115168491 @default.
- W2982046601 cites W2117010174 @default.
- W2982046601 cites W2119610099 @default.
- W2982046601 cites W2120628526 @default.
- W2982046601 cites W2122905516 @default.
- W2982046601 cites W2122955029 @default.
- W2982046601 cites W2125149512 @default.
- W2982046601 cites W2128523475 @default.
- W2982046601 cites W2129032286 @default.
- W2982046601 cites W2132889095 @default.
- W2982046601 cites W2133128074 @default.
- W2982046601 cites W2133335974 @default.
- W2982046601 cites W2134620558 @default.
- W2982046601 cites W2135369850 @default.
- W2982046601 cites W2141954297 @default.
- W2982046601 cites W2144215255 @default.
- W2982046601 cites W2146678743 @default.
- W2982046601 cites W2151856267 @default.
- W2982046601 cites W2152664824 @default.
- W2982046601 cites W2157348568 @default.
- W2982046601 cites W2159639847 @default.
- W2982046601 cites W2161723579 @default.