FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982050900> ?p ?o ?g. }

• W2982050900 abstract "The twin processes of viral evolutionary escape and reversion in response to host immune pressure, in particular the cytotoxic T-lymphocyte (CTL) response, shape Human Immunodeficiency Virus-1 sequence evolution in infected host populations. The tempo of CTL escape and reversion is known to differ between CTL escape variants in a given host population. Here, we ask: are rates of escape and reversion comparable across infected host populations? For three cohorts taken from three continents, we estimate escape and reversion rates at 23 escape sites in optimally defined Gag epitopes. We find consistent escape rate estimates across the examined cohorts. Reversion rates are also consistent between a Canadian and South African infected host population. Certain Gag escape variants that incur a large replicative fitness cost are known to revert rapidly upon transmission. However, the relationship between escape/reversion rates and viral replicative capacity across a large number of epitopes has not been interrogated. We investigate this relationship by examining $in$ $vitro$ replicative capacities of viral sequences with minimal variation: point escape mutants induced in a lab strain. Remarkably, despite the complexities of epistatic effects exemplified by pathways to escape in famous epitopes, and the diversity of both hosts and viruses, CTL escape mutants which escape rapidly tend to be those with the highest replicative capacity when applied as a single point mutation. Similarly, mutants inducing the greatest costs to viral replicative capacity tend to revert more quickly. These data suggest that escape rates in Gag are consistent across host populations, and that in general these rates are dominated by site specific effects upon viral replicative capacity." @default.
• W2982050900 created "2019-11-01" @default.
• W2982050900 creator A5001255253 @default.
• W2982050900 creator A5001975845 @default.
• W2982050900 creator A5018523831 @default.
• W2982050900 creator A5028648548 @default.
• W2982050900 creator A5030501259 @default.
• W2982050900 creator A5035351719 @default.
• W2982050900 creator A5040954811 @default.
• W2982050900 creator A5043290778 @default.
• W2982050900 creator A5043346206 @default.
• W2982050900 creator A5078326079 @default.
• W2982050900 creator A5087925820 @default.
• W2982050900 date "2015-06-04" @default.
• W2982050900 modified "2023-09-26" @default.
• W2982050900 title "Predictable patterns of CTL escape and reversion and the limited role of epistasis in HIV-1 evolution" @default.
• W2982050900 hasPublicationYear "2015" @default.
• W2982050900 type Work @default.
• W2982050900 sameAs 2982050900 @default.
• W2982050900 citedByCount "0" @default.
• W2982050900 crossrefType "posted-content" @default.
• W2982050900 hasAuthorship W2982050900A5001255253 @default.
• W2982050900 hasAuthorship W2982050900A5001975845 @default.
• W2982050900 hasAuthorship W2982050900A5018523831 @default.
• W2982050900 hasAuthorship W2982050900A5028648548 @default.
• W2982050900 hasAuthorship W2982050900A5030501259 @default.
• W2982050900 hasAuthorship W2982050900A5035351719 @default.
• W2982050900 hasAuthorship W2982050900A5040954811 @default.
• W2982050900 hasAuthorship W2982050900A5043290778 @default.
• W2982050900 hasAuthorship W2982050900A5043346206 @default.
• W2982050900 hasAuthorship W2982050900A5078326079 @default.
• W2982050900 hasAuthorship W2982050900A5087925820 @default.
• W2982050900 hasConcept C104317684 @default.
• W2982050900 hasConcept C126831891 @default.
• W2982050900 hasConcept C127716648 @default.
• W2982050900 hasConcept C144024400 @default.
• W2982050900 hasConcept C147969180 @default.
• W2982050900 hasConcept C149923435 @default.
• W2982050900 hasConcept C154317977 @default.
• W2982050900 hasConcept C159047783 @default.
• W2982050900 hasConcept C176944494 @default.
• W2982050900 hasConcept C202751555 @default.
• W2982050900 hasConcept C2522874641 @default.
• W2982050900 hasConcept C2908647359 @default.
• W2982050900 hasConcept C2910387474 @default.
• W2982050900 hasConcept C2988562018 @default.
• W2982050900 hasConcept C501734568 @default.
• W2982050900 hasConcept C54355233 @default.
• W2982050900 hasConcept C61727976 @default.
• W2982050900 hasConcept C67705224 @default.
• W2982050900 hasConcept C70883133 @default.
• W2982050900 hasConcept C78458016 @default.
• W2982050900 hasConcept C86803240 @default.
• W2982050900 hasConcept C8769409 @default.
• W2982050900 hasConcept C98638677 @default.
• W2982050900 hasConceptScore W2982050900C104317684 @default.
• W2982050900 hasConceptScore W2982050900C126831891 @default.
• W2982050900 hasConceptScore W2982050900C127716648 @default.
• W2982050900 hasConceptScore W2982050900C144024400 @default.
• W2982050900 hasConceptScore W2982050900C147969180 @default.
• W2982050900 hasConceptScore W2982050900C149923435 @default.
• W2982050900 hasConceptScore W2982050900C154317977 @default.
• W2982050900 hasConceptScore W2982050900C159047783 @default.
• W2982050900 hasConceptScore W2982050900C176944494 @default.
• W2982050900 hasConceptScore W2982050900C202751555 @default.
• W2982050900 hasConceptScore W2982050900C2522874641 @default.
• W2982050900 hasConceptScore W2982050900C2908647359 @default.
• W2982050900 hasConceptScore W2982050900C2910387474 @default.
• W2982050900 hasConceptScore W2982050900C2988562018 @default.
• W2982050900 hasConceptScore W2982050900C501734568 @default.
• W2982050900 hasConceptScore W2982050900C54355233 @default.
• W2982050900 hasConceptScore W2982050900C61727976 @default.
• W2982050900 hasConceptScore W2982050900C67705224 @default.
• W2982050900 hasConceptScore W2982050900C70883133 @default.
• W2982050900 hasConceptScore W2982050900C78458016 @default.
• W2982050900 hasConceptScore W2982050900C86803240 @default.
• W2982050900 hasConceptScore W2982050900C8769409 @default.
• W2982050900 hasConceptScore W2982050900C98638677 @default.
• W2982050900 hasLocation W29820509001 @default.
• W2982050900 hasOpenAccess W2982050900 @default.
• W2982050900 hasPrimaryLocation W29820509001 @default.
• W2982050900 hasRelatedWork W1817014772 @default.
• W2982050900 hasRelatedWork W1995598331 @default.
• W2982050900 hasRelatedWork W2002380506 @default.
• W2982050900 hasRelatedWork W2057130751 @default.
• W2982050900 hasRelatedWork W2090653286 @default.
• W2982050900 hasRelatedWork W2092297539 @default.
• W2982050900 hasRelatedWork W2100431060 @default.
• W2982050900 hasRelatedWork W2117937015 @default.
• W2982050900 hasRelatedWork W2118704092 @default.
• W2982050900 hasRelatedWork W2143545316 @default.
• W2982050900 hasRelatedWork W2159826655 @default.
• W2982050900 hasRelatedWork W2199500517 @default.
• W2982050900 hasRelatedWork W2202693501 @default.
• W2982050900 hasRelatedWork W2256829711 @default.
• W2982050900 hasRelatedWork W2301803317 @default.
• W2982050900 hasRelatedWork W2461540377 @default.
• W2982050900 hasRelatedWork W2594425558 @default.
• W2982050900 hasRelatedWork W2779332164 @default.
• W2982050900 hasRelatedWork W2950710757 @default.

• next