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• W2982116132 abstract "Noise-induced hearing loss generally induces loudness recruitment, but sometimes gives rise to hyperacusis, a debilitating condition in which moderate intensity sounds are perceived abnormally loud. In an attempt to develop an animal model of loudness hyperacusis, we exposed rats to a 16-20 kHz noise at 104 dB SPL for 12 weeks. Behavioral reaction time-intensity functions were used to assess loudness growth functions before, during and 2-months post-exposure. During the exposure, loudness recruitment (R) was present in the region of hearing loss, but subtle evidence of hyperacusis (H) started to emerge at the border of the hearing loss. Unexpectedly, robust evidence of hyperacusis appeared below and near the edge of the hearing loss 2-months post-exposure. To identify the neural correlates of hyperacusis and test the central gain model of hyperacusis, we recorded population neural responses from the cochlea, auditory cortex and lateral amygdala 2-months post-exposure. Compared to controls, the neural output of the cochlea was greatly reduced in the noise group. Consistent with central gain models, the gross neural responses from the auditory cortex and amygdala were proportionately much larger than those from the cochlea. However, despite central amplification, the population responses in the auditory cortex and amygdala were still below the level needed to fully account for hyperacusis and/or recruitment. Having developed procedures that can consistently induce hyperacusis in rats, our results set the stage for future studies that seek to identify the neurobiological events that give rise to hyperacusis and to develop new therapies to treat this debilitating condition." @default.
• W2982116132 created "2019-11-01" @default.
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• W2982116132 date "2019-12-01" @default.
• W2982116132 modified "2023-09-27" @default.
• W2982116132 title "Noise-Induced loudness recruitment and hyperacusis: Insufficient central gain in auditory cortex and amygdala" @default.
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• W2982116132 cites W1927347762 @default.
• W2982116132 cites W1963515539 @default.
• W2982116132 cites W1964270017 @default.
• W2982116132 cites W1970303222 @default.
• W2982116132 cites W1970440211 @default.
• W2982116132 cites W1970727835 @default.
• W2982116132 cites W1973458820 @default.
• W2982116132 cites W1977024839 @default.
• W2982116132 cites W1980290998 @default.
• W2982116132 cites W1981296801 @default.
• W2982116132 cites W1981815757 @default.
• W2982116132 cites W1984890451 @default.
• W2982116132 cites W1992166555 @default.
• W2982116132 cites W1992246079 @default.
• W2982116132 cites W1993458346 @default.
• W2982116132 cites W1993829642 @default.
• W2982116132 cites W1994303136 @default.
• W2982116132 cites W1996135966 @default.
• W2982116132 cites W1997854021 @default.
• W2982116132 cites W2000526862 @default.
• W2982116132 cites W2001181410 @default.
• W2982116132 cites W2004774625 @default.
• W2982116132 cites W2007070255 @default.
• W2982116132 cites W2008973241 @default.
• W2982116132 cites W2015847657 @default.
• W2982116132 cites W2017792517 @default.
• W2982116132 cites W2021100547 @default.
• W2982116132 cites W2021697693 @default.
• W2982116132 cites W2027917652 @default.
• W2982116132 cites W2032242933 @default.
• W2982116132 cites W2039663796 @default.
• W2982116132 cites W2043149567 @default.
• W2982116132 cites W2044687954 @default.
• W2982116132 cites W2051512454 @default.
• W2982116132 cites W2055644190 @default.
• W2982116132 cites W2058002530 @default.
• W2982116132 cites W2059908764 @default.
• W2982116132 cites W2064504453 @default.
• W2982116132 cites W2066877874 @default.
• W2982116132 cites W2068815286 @default.
• W2982116132 cites W2070776139 @default.
• W2982116132 cites W2074558532 @default.
• W2982116132 cites W2076263559 @default.
• W2982116132 cites W2093570658 @default.
• W2982116132 cites W2095319435 @default.
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• W2982116132 cites W2163122493 @default.
• W2982116132 cites W2168362146 @default.
• W2982116132 cites W2171084703 @default.
• W2982116132 cites W2210264310 @default.
• W2982116132 cites W2269259465 @default.
• W2982116132 cites W2318947565 @default.
• W2982116132 cites W2516467696 @default.
• W2982116132 cites W2541929282 @default.
• W2982116132 cites W2575847055 @default.
• W2982116132 cites W2592878232 @default.
• W2982116132 cites W2607888276 @default.
• W2982116132 cites W2728911988 @default.
• W2982116132 cites W2734441615 @default.
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• W2982116132 cites W3044784294 @default.
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• W2982116132 doi "https://doi.org/10.1016/j.neuroscience.2019.09.010" @default.
• W2982116132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6994858" @default.
• W2982116132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31669363" @default.
• W2982116132 hasPublicationYear "2019" @default.
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