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- W2982122110 abstract "It has been shown that 10% or less in the number of live tumor cells in patients who underwent surgery after neoadjuvant/induction (N/I) treatment for locally advanced non-small cell lung cancer (NSCLC) is a more important prognostic factor than the tumor diameter. Therefore, to improve the accuracy of TNM staging, the IASLC recommends calculating the new pathological ypT stage by multiplying the percentage of viable tumor cells with the total tumor size (Picture 1). The aim of this study was to determine the effect of this recommendation on long-term survival rates. Data of 1190 patients who underwent segmentectomy or larger lung resections for NSCLC in our academic center between 1996 and 2017 were prospectively recorded and evaluated retrospectively. Four hundred and sixty-nine (39.4%) patients who underwent surgery after N/I treatment for locally advanced NSCLC were included in the study. The patients were divided into 3 groups; Pathological complete response (CR, Group 1) as defined as no viable tumor cells regardless of tumor size, group 2 was accepted as near complete response (nCR), where the tumor contained ≤%10 live tumor cells, tumor size >5 cm without lymph node metastasis, group 3 consisted of ypStage1 patients. The long term survival and its impacting factors were analyzed. In histopathological examination, 16.6% (78/469) patients had CR, 4% (19/469) had nCR, 17.7% (83/469) had ypStage 1a and 7.7% (36/469) had ypStage 1b. Five-year survival; 72.5% in Group 1, 30% in Group 2 and 63.4% in Group 3. The best survival was observed in patients with pathological CR. Although, IASLC suggests that the nCR should be considered as Stage 1, because of the significantly low survival figures, T3-4 seems to be the more appropriate classification than the IASLC proposal." @default.
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- W2982122110 date "2019-10-01" @default.
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- W2982122110 title "P2.13-06 Finding a Place for Pathological Near Complete Response Patients Following Neoadjuvant/Induction Therapy in the TNM Staging" @default.
- W2982122110 doi "https://doi.org/10.1016/j.jtho.2019.08.1777" @default.
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