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- W2982123354 abstract "Since S-adenosylmethionine (SAM) was identified as the most important methyl donor in the body by Cantoni et al. in 1951, various physiological actions have been shown for this substance. Among the various physiological actions of SAM, the effects on phospholipid metabolism, i.e. facilitative effects on phosphatidylcholine biosynthesis and on the metabolism of physiologically active brain amines. This report shows the effects of SAM in healthy animals determined using parameters such as spontaneous motor activity, levels of brain monoamines glucose, glucose-metabolites relating substances,ATP and phospholipids, in comparison with CDP-choline. these substances were injected intravenously or intraperitoneally. An injection of SAM at over 10mg/kg resulted in a slight increase in spontaneous motor activity, but CDP-choline caused no change. An inclination to awake was observed in spontaneous EGG with both of these substances. Regarding brain-monoamines related substance, DA tended to be increased with CDP-choline of over 50mg/kg, and tendencies for increases of HVA and 5-HIAA were observed with SAM of over 10mg/kg." @default.
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- W2982123354 date "1983-01-01" @default.
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- W2982123354 title "Pharmacological study of S-adenosylmethionine (SAM)-1st Report-With special reference to spontaneous motor activity and brain monoamines in rats" @default.
- W2982123354 doi "https://doi.org/10.1016/s0021-5198(19)64783-9" @default.
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