FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982129075> ?p ?o ?g. }

• W2982129075 abstract "Abstract Cyclophosphamide+total body irradiation +/− etoposide (CyTBI+/−V) is a standard conditioning regimen prior to auto-SCT for NHL patients. However, TBI-based dose intensive therapy is often contraindicated in older patients, or those with prior radiation. We performed a single-institution Phase II non-randomized prospective study of VCyTBI vs. Busulfan+Cy (BuCy) to determine if BuCy provides comparable disease control to standard dose intensive therapy with VCyTBI. BuCy was used in patients ≥60 years and when TBI was contraindicated. Seventy-five relapsed or refractory NHL patients underwent auto-SCT at Roswell Park Cancer Institute from 8/92 to 7/05. All patients were treated on a single IRB-approved protocol with standard eligibility criteria including age ≥18 and ≤70, adequate cardiac, pulmonary, hepatic and renal function and KPS ≥70. All patients signed informed consent and were followed prospectively. All data have been de-identified. Survival status for all patients was updated through 8/1/08. VCyTBI (N=47) consisted of V 1800 mg/m2 26-hour continuous iv infusion on day -5, Cy 60 mg/kg day -4 (12 patients received 180 mg/kg total dose), and TBI 200 cGy on days -3, -2, and -1 for total dose of 1000 cGy (8 patients received 1200 cGy). BuCy (N=28) consisted of iv Bu 0.8 mg/kg every 6 hours on days -7, -6, -5, -4 (total 12.8mg, one patient received oral Bu total dose 16 mg/kg) and Cy 60 mg/kg on days -3 and -2 (total 120 mg/kg, one patient received total dose 200 mg/kg). Eight patients received iv Bu without dose adjustment and 19 received iv Bu with dose adjusted to maintain a steady state level between 600– 900 ng/ml. Stem cells were re-infused on day 0. Patients received peripheral blood stem cells (n=53), bone marrow (n=14) or both (n=8). The median age was significantly higher in the BuCy compared to the VCyTBI group (61.5 vs 53 years, p=0.0002), and there were fewer patients with a KPS of 90–100 in the VCyTBI group (75% vs 93%, p=0.07). There were no significant differences on the following patient characteristics by BuCy vs VCyTBI: gender, disease risk, stem cell source, histology (diffuse, follicular, mantle, other), or remission status at SCT. Treatment-related mortality at day+100 post-auto SCT was very low in both groups: 0% in BuCy and 2% in VCyTBI. However, 3 patients in the VCyTBI group and none in the BuCy group developed AML at 1.3, 1.8 and 6.5 years post-auto-SCT. At a median follow-up of 4.6 years, the 5-year progression-free survival for BuCy and VCyTBI was 32% (95% CI 14–50%) and 24% (95% CI, 11–39%, P&gt;0.8), respectively. The 5-year overall survival for BuCy and VCyTBI was 46% (95% CI 25– 64%) and 49% (95% CI 33–64%, P&gt;0.7), respectively. Multivariate analysis controlling for age and KPS at BMT also demonstrated no significant difference between BuCy and VCyTBI for either progression-free (RR=0.9, 95% CI 0.5–1.8) or overall (RR=0.7, 95% CI 0.3–1.6) survival. This is the largest reported study evaluating the efficacy of BuCy as alternative conditioning for auto-SCT in relapsed/refractory NHL. BuCy provides equivalent survival outcomes to VCyTBI as conditioning for auto-SCT in NHL patients. Based on these results, our practice continues to use BuCy for NHL patients ≥60 years." @default.
• W2982129075 created "2019-11-01" @default.
• W2982129075 creator A5009362911 @default.
• W2982129075 creator A5016601438 @default.
• W2982129075 creator A5031293676 @default.
• W2982129075 creator A5063351800 @default.
• W2982129075 creator A5065815399 @default.
• W2982129075 creator A5075486570 @default.
• W2982129075 date "2008-11-16" @default.
• W2982129075 modified "2023-09-29" @default.
• W2982129075 title "BuCy Provides Equivalent Outcomes to VCyTBI as Conditioning Prior to Auto-SCT in Patients with Relapsed/Refractory NHL and Is a Valuable Option in Older (≥60 years) Patients." @default.
• W2982129075 doi "https://doi.org/10.1182/blood.v112.11.2176.2176" @default.
• W2982129075 hasPublicationYear "2008" @default.
• W2982129075 type Work @default.
• W2982129075 sameAs 2982129075 @default.
• W2982129075 citedByCount "0" @default.
• W2982129075 crossrefType "journal-article" @default.
• W2982129075 hasAuthorship W2982129075A5009362911 @default.
• W2982129075 hasAuthorship W2982129075A5016601438 @default.
• W2982129075 hasAuthorship W2982129075A5031293676 @default.
• W2982129075 hasAuthorship W2982129075A5063351800 @default.
• W2982129075 hasAuthorship W2982129075A5065815399 @default.
• W2982129075 hasAuthorship W2982129075A5075486570 @default.
• W2982129075 hasConcept C121332964 @default.
• W2982129075 hasConcept C126322002 @default.
• W2982129075 hasConcept C141071460 @default.
• W2982129075 hasConcept C142424586 @default.
• W2982129075 hasConcept C2776694085 @default.
• W2982129075 hasConcept C2776755627 @default.
• W2982129075 hasConcept C2780611847 @default.
• W2982129075 hasConcept C2781413609 @default.
• W2982129075 hasConcept C71924100 @default.
• W2982129075 hasConcept C87355193 @default.
• W2982129075 hasConceptScore W2982129075C121332964 @default.
• W2982129075 hasConceptScore W2982129075C126322002 @default.
• W2982129075 hasConceptScore W2982129075C141071460 @default.
• W2982129075 hasConceptScore W2982129075C142424586 @default.
• W2982129075 hasConceptScore W2982129075C2776694085 @default.
• W2982129075 hasConceptScore W2982129075C2776755627 @default.
• W2982129075 hasConceptScore W2982129075C2780611847 @default.
• W2982129075 hasConceptScore W2982129075C2781413609 @default.
• W2982129075 hasConceptScore W2982129075C71924100 @default.
• W2982129075 hasConceptScore W2982129075C87355193 @default.
• W2982129075 hasLocation W29821290751 @default.
• W2982129075 hasOpenAccess W2982129075 @default.
• W2982129075 hasPrimaryLocation W29821290751 @default.
• W2982129075 hasRelatedWork W110982080 @default.
• W2982129075 hasRelatedWork W1670276122 @default.
• W2982129075 hasRelatedWork W2285467945 @default.
• W2982129075 hasRelatedWork W2405671302 @default.
• W2982129075 hasRelatedWork W2526086852 @default.
• W2982129075 hasRelatedWork W2533918102 @default.
• W2982129075 hasRelatedWork W2551420153 @default.
• W2982129075 hasRelatedWork W2552321098 @default.
• W2982129075 hasRelatedWork W2554284156 @default.
• W2982129075 hasRelatedWork W2558322760 @default.
• W2982129075 hasRelatedWork W2561213299 @default.
• W2982129075 hasRelatedWork W2570138518 @default.
• W2982129075 hasRelatedWork W2575554787 @default.
• W2982129075 hasRelatedWork W2582424465 @default.
• W2982129075 hasRelatedWork W2584876290 @default.
• W2982129075 hasRelatedWork W2587141472 @default.
• W2982129075 hasRelatedWork W2979982544 @default.
• W2982129075 hasRelatedWork W2980021387 @default.
• W2982129075 hasRelatedWork W3198746234 @default.
• W2982129075 hasRelatedWork W2397105609 @default.
• W2982129075 isParatext "false" @default.
• W2982129075 isRetracted "false" @default.
• W2982129075 magId "2982129075" @default.
• W2982129075 workType "article" @default.