FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982144433> ?p ?o ?g. }

• W2982144433 abstract "Abstract Background Children with sickle cell anemia (SCA) are highly susceptible to stroke and other manifestations of pediatric cerebral vasculopathy. Detailed evaluations in sub-Saharan Africa are limited. Methods We aimed to establish the frequency and types of pediatric brain injury in a cross-sectional study at a large SCA clinic in Kampala, Uganda in a randomly selected sample of 265 patients with HbSS ages 1–12 years. Brain injury was defined as one or more abnormality on standardized testing: neurocognitive impairment using an age-appropriate test battery, prior stroke by examination or transcranial Doppler (TCD) velocities associated with stroke risk in children with SCA (cerebral arterial time averaged mean maximum velocity ≥ 170 cm/second). Results Mean age was 5.5 ± 2.9 years; 52.3% were male. Mean hemoglobin was 7.3 ± 1.01 g/dl; 76.4% had hemoglobin < 8.0 g/dl. Using established international standards, 14.7% were malnourished, and was more common in children ages 5–12. Overall, 57 (21.5%) subjects had one to three abnormal primary testing. Neurocognitive dysfunction was found in 27, while prior stroke was detected in 15 (5.7%). The most frequent abnormality was elevated TCD velocity 43 (18.1%), of which five (2.1%) were in the highest velocity range of abnormal. Only impaired neurocognitive dysfunction increased with age (OR 1.44, 95%CI 1.23–1.68), p < 0.001). In univariate models, malnutrition defined as wasting (weight-for-height ≤ −2SD), but not sex or hemoglobin, was modestly related to elevated TCD (OR 1.37, 95%CI 1.01–1.86, p = 0.04). In adjusted models, neurocognitive dysfunction was strongly related to prior stroke (OR 6.88, 95%CI 1.95–24.3, p = .003) and to abnormal TCD (OR 4.37, 95%CI 1.30, p = 0.02). In a subset of 81 subjects who were enriched for other abnormal results, magnetic resonance imaging and angiography (MRI/MRA) detected infarcts and/or arterial stenosis in 52%. Thirteen subjects (25%) with abnormal imaging had no other abnormalities detected. Conclusions The high frequency of neurocognitive impairment or other abnormal results describes a large burden of pediatric SCA brain disease in Uganda. Evaluation by any single modality would have underestimated the impact of SCA. Testing the impact of hydroxyurea or other available disease-modifying interventions for reducing or preventing SCA brain effects is warranted." @default.
• W2982144433 created "2019-11-01" @default.
• W2982144433 creator A5001306046 @default.
• W2982144433 creator A5003485099 @default.
• W2982144433 creator A5004747457 @default.
• W2982144433 creator A5007442463 @default.
• W2982144433 creator A5017538208 @default.
• W2982144433 creator A5020178574 @default.
• W2982144433 creator A5023049307 @default.
• W2982144433 creator A5024124240 @default.
• W2982144433 creator A5024317259 @default.
• W2982144433 creator A5035161117 @default.
• W2982144433 creator A5040402984 @default.
• W2982144433 creator A5044001573 @default.
• W2982144433 creator A5049035869 @default.
• W2982144433 creator A5058072957 @default.
• W2982144433 creator A5061486870 @default.
• W2982144433 creator A5062509997 @default.
• W2982144433 creator A5071591610 @default.
• W2982144433 creator A5073382005 @default.
• W2982144433 creator A5074362667 @default.
• W2982144433 creator A5081375079 @default.
• W2982144433 creator A5087201620 @default.
• W2982144433 creator A5089553987 @default.
• W2982144433 creator A5091878010 @default.
• W2982144433 date "2019-10-25" @default.
• W2982144433 modified "2023-10-07" @default.
• W2982144433 title "Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study" @default.
• W2982144433 cites W1480294594 @default.
• W2982144433 cites W1510545487 @default.
• W2982144433 cites W1527011915 @default.
• W2982144433 cites W1763433851 @default.
• W2982144433 cites W1797876399 @default.
• W2982144433 cites W1958232709 @default.
• W2982144433 cites W1966362593 @default.
• W2982144433 cites W1968793410 @default.
• W2982144433 cites W1979032722 @default.
• W2982144433 cites W1981726185 @default.
• W2982144433 cites W1984789764 @default.
• W2982144433 cites W1988019475 @default.
• W2982144433 cites W1999936817 @default.
• W2982144433 cites W2000643072 @default.
• W2982144433 cites W2025568946 @default.
• W2982144433 cites W2025723371 @default.
• W2982144433 cites W2027662398 @default.
• W2982144433 cites W2028658755 @default.
• W2982144433 cites W2036974652 @default.
• W2982144433 cites W2040567458 @default.
• W2982144433 cites W2046529604 @default.
• W2982144433 cites W2056245658 @default.
• W2982144433 cites W2060968014 @default.
• W2982144433 cites W2061935394 @default.
• W2982144433 cites W2076949422 @default.
• W2982144433 cites W2083397096 @default.
• W2982144433 cites W2092410778 @default.
• W2982144433 cites W2093143355 @default.
• W2982144433 cites W2101539929 @default.
• W2982144433 cites W2104724413 @default.
• W2982144433 cites W2107582491 @default.
• W2982144433 cites W2152626840 @default.
• W2982144433 cites W2155403187 @default.
• W2982144433 cites W2159010777 @default.
• W2982144433 cites W2178321006 @default.
• W2982144433 cites W2258412265 @default.
• W2982144433 cites W2296704420 @default.
• W2982144433 cites W2313841032 @default.
• W2982144433 cites W2315155986 @default.
• W2982144433 cites W2326592352 @default.
• W2982144433 cites W2465420427 @default.
• W2982144433 cites W2466187208 @default.
• W2982144433 cites W2495182816 @default.
• W2982144433 cites W2519505147 @default.
• W2982144433 cites W2524463896 @default.
• W2982144433 cites W2548836926 @default.
• W2982144433 cites W2568329035 @default.
• W2982144433 cites W2607699826 @default.
• W2982144433 cites W2748229577 @default.
• W2982144433 cites W2753640335 @default.
• W2982144433 cites W2765798560 @default.
• W2982144433 cites W2793395625 @default.
• W2982144433 cites W2804932120 @default.
• W2982144433 cites W2895372660 @default.
• W2982144433 cites W2902147263 @default.
• W2982144433 cites W2952384867 @default.
• W2982144433 cites W3141197395 @default.
• W2982144433 cites W4205578020 @default.
• W2982144433 cites W4211242268 @default.
• W2982144433 doi "https://doi.org/10.1186/s12887-019-1758-2" @default.
• W2982144433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6814102" @default.
• W2982144433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31651270" @default.
• W2982144433 hasPublicationYear "2019" @default.
• W2982144433 type Work @default.
• W2982144433 sameAs 2982144433 @default.
• W2982144433 citedByCount "8" @default.
• W2982144433 countsByYear W29821444332020 @default.
• W2982144433 countsByYear W29821444332021 @default.
• W2982144433 countsByYear W29821444332022 @default.
• W2982144433 countsByYear W29821444332023 @default.
• W2982144433 crossrefType "journal-article" @default.
• W2982144433 hasAuthorship W2982144433A5001306046 @default.

• next