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- W2982147887 abstract "Innate immunity is the first line of defense after the entry of any pathogen into the body and is nonspecific in nature. The components of innate immunity may be classified broadly as epithelial barriers, cells, and humoral components. The pattern recognition receptors (toll-like receptors, CD14) and soluble factors (acute-phase proteins such as plasma protein, C-reactive protein, fibrin, complement, interferon, properdin, lactoferrin, transferrin, lactoperoxidase, lysozyme, and cytokines are mostly proteins and expressed and coded by respective genes. The chapter describes two possible modes of genetic control. First is the qualitative aspect, mutation in the coding region of a gene that leads to single-nucleotide polymorphism. The particular mutation may alter the domain of the peptide, its configuration, or the 3-D structure, leading to diminished function. Second is the quantitative expression level of the gene responsible for inflammatory mediators/cytokines assessed through real-time polymerase chain reaction. This genetic control may be due to mutation of the promoter region of the gene." @default.
- W2982147887 created "2019-11-01" @default.
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- W2982147887 date "2020-01-01" @default.
- W2982147887 modified "2023-09-25" @default.
- W2982147887 title "Genetics for innate immunity" @default.
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- W2982147887 doi "https://doi.org/10.1016/b978-0-12-816406-8.00005-x" @default.
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