FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982149592> ?p ?o ?g. }

• W2982149592 abstract "Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings resulting from pathological processes of various etiologies affecting cerebral arterioles, perforating arteries, capillaries, and venules. Unlike large vessels, it is a challenge to visualize small vessels in vivo, hence the difficulty to directly monitor the natural progression of the disease. CSVD might progress for many years during the early stage of the disease as it remains asymptomatic. Prevalent among elderly individuals, CSVD has been alarmingly reported as an important precursor of full-blown stroke and vascular dementia. Growing evidence has also shown a significant association between CSVD's radiological manifestation with dementia and Alzheimer's disease (AD) pathology. Although it remains contentious as to whether CSVD is a cause or sequelae of AD, it is not far-fetched to posit that effective therapeutic measures of CSVD would mitigate the overall burden of dementia. Nevertheless, the unifying theory on the pathomechanism of the disease remains elusive, hence the lack of effective therapeutic approaches. Thus, this chapter consolidates the contemporary insights from numerous experimental animal models of CSVD, to date: from the available experimental animal models of CSVD and its translational research value; the pathomechanical aspects of the disease; relevant aspects on systems biology; opportunities for early disease biomarkers; and finally, converging approaches for future therapeutic directions of CSVD." @default.
• W2982149592 created "2019-11-01" @default.
• W2982149592 creator A5006355000 @default.
• W2982149592 creator A5012216267 @default.
• W2982149592 creator A5019304303 @default.
• W2982149592 creator A5031286061 @default.
• W2982149592 creator A5039678790 @default.
• W2982149592 date "2019-10-24" @default.
• W2982149592 modified "2023-10-15" @default.
• W2982149592 title "Cerebral Small Vessel Disease (CSVD) – Lessons From the Animal Models" @default.
• W2982149592 cites W1038803133 @default.
• W2982149592 cites W1480729244 @default.
• W2982149592 cites W1503983308 @default.
• W2982149592 cites W1530184695 @default.
• W2982149592 cites W1534761457 @default.
• W2982149592 cites W1542743627 @default.
• W2982149592 cites W1551254781 @default.
• W2982149592 cites W1565215438 @default.
• W2982149592 cites W1578359906 @default.
• W2982149592 cites W1583367908 @default.
• W2982149592 cites W1584701817 @default.
• W2982149592 cites W1625373986 @default.
• W2982149592 cites W1693284829 @default.
• W2982149592 cites W1775766478 @default.
• W2982149592 cites W1796054280 @default.
• W2982149592 cites W1827602057 @default.
• W2982149592 cites W1852856437 @default.
• W2982149592 cites W1871009028 @default.
• W2982149592 cites W1904567056 @default.
• W2982149592 cites W1908464783 @default.
• W2982149592 cites W191849520 @default.
• W2982149592 cites W1922323234 @default.
• W2982149592 cites W1934683982 @default.
• W2982149592 cites W1937673325 @default.
• W2982149592 cites W1965180269 @default.
• W2982149592 cites W1965440332 @default.
• W2982149592 cites W1965853784 @default.
• W2982149592 cites W1967134185 @default.
• W2982149592 cites W1967290706 @default.
• W2982149592 cites W1968942686 @default.
• W2982149592 cites W1969700660 @default.
• W2982149592 cites W1974740897 @default.
• W2982149592 cites W1974997758 @default.
• W2982149592 cites W1975511880 @default.
• W2982149592 cites W1976239472 @default.
• W2982149592 cites W1977163687 @default.
• W2982149592 cites W1980092395 @default.
• W2982149592 cites W1980455197 @default.
• W2982149592 cites W198260912 @default.
• W2982149592 cites W1982947392 @default.
• W2982149592 cites W1986281881 @default.
• W2982149592 cites W1986941443 @default.
• W2982149592 cites W1987341051 @default.
• W2982149592 cites W1988003366 @default.
• W2982149592 cites W1989049439 @default.
• W2982149592 cites W1990695728 @default.
• W2982149592 cites W1990948493 @default.
• W2982149592 cites W1991393281 @default.
• W2982149592 cites W1991655882 @default.
• W2982149592 cites W1994137501 @default.
• W2982149592 cites W1995986656 @default.
• W2982149592 cites W1996427377 @default.
• W2982149592 cites W1998401874 @default.
• W2982149592 cites W2002082105 @default.
• W2982149592 cites W2002233953 @default.
• W2982149592 cites W2003982930 @default.
• W2982149592 cites W2004636250 @default.
• W2982149592 cites W2004906982 @default.
• W2982149592 cites W2005016776 @default.
• W2982149592 cites W2005059170 @default.
• W2982149592 cites W2006517595 @default.
• W2982149592 cites W2006912547 @default.
• W2982149592 cites W2013544411 @default.
• W2982149592 cites W2019977416 @default.
• W2982149592 cites W2020503343 @default.
• W2982149592 cites W2020935778 @default.
• W2982149592 cites W2021556801 @default.
• W2982149592 cites W2021937385 @default.
• W2982149592 cites W2022092287 @default.
• W2982149592 cites W2022857700 @default.
• W2982149592 cites W2025047388 @default.
• W2982149592 cites W2025313184 @default.
• W2982149592 cites W2026070709 @default.
• W2982149592 cites W2026909977 @default.
• W2982149592 cites W2029361628 @default.
• W2982149592 cites W2029436652 @default.
• W2982149592 cites W2034275438 @default.
• W2982149592 cites W2034446184 @default.
• W2982149592 cites W2037394994 @default.
• W2982149592 cites W2038181474 @default.
• W2982149592 cites W2043298511 @default.
• W2982149592 cites W2043557983 @default.
• W2982149592 cites W2044287921 @default.
• W2982149592 cites W2044474340 @default.
• W2982149592 cites W2047152236 @default.
• W2982149592 cites W2047559009 @default.
• W2982149592 cites W2051152021 @default.
• W2982149592 cites W2051714172 @default.
• W2982149592 cites W2054025659 @default.
• W2982149592 cites W2056035231 @default.

• next