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- W2982156914 endingPage "161" @default.
- W2982156914 startingPage "161" @default.
- W2982156914 abstract "Prostate cancer (PCa) is one of the most common cancers in men that usually develops slowly. Since diagnostic methods improved in the last decade and are highly precise, more cancers are diagnosed at an early stage. Active surveillance or watchful waiting are appealing approaches for men diagnosed with low-risk prostate cancer, and they are an antidote to the overtreatment problem and unnecessary biopsies. However, treatment depends on individual circumstances of a patient. Older hormonal therapies based on first generation antiandrogens and steroids were widely used in metastatic castration-resistant prostate cancer (mCRPC) patients prior to the implementation of docetaxel. Nowadays, accordingly to randomized clinical trials, abiraterone, enzalutamide, apalutamide. and docetaxel became first line agents administrated in the treatment of mCRPC. Furthermore, radium-223 is an optional therapy for bone-only metastasis patients. Sipuleucel-T demonstrated an overall survival benefit. However, other novel immunotherapeutics showed limitations in monotherapy. Possible combinations of new vaccines or immune checkpoint blockers with enzalutamide, abiraterone, radium-223, or docetaxel are the subject of ongoing rivalry regarding optimal therapy of prostate cancer." @default.
- W2982156914 created "2019-11-01" @default.
- W2982156914 creator A5006304294 @default.
- W2982156914 creator A5011484331 @default.
- W2982156914 creator A5015212397 @default.
- W2982156914 creator A5060104907 @default.
- W2982156914 creator A5061989777 @default.
- W2982156914 date "2019-10-25" @default.
- W2982156914 modified "2023-10-18" @default.
- W2982156914 title "Previous, Current, and Future Pharmacotherapy and Diagnosis of Prostate Cancer—A Comprehensive Review" @default.
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