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- W2982171454 endingPage "107830" @default.
- W2982171454 startingPage "107830" @default.
- W2982171454 abstract "Since its discovery in 1993, the serotonin receptor subtype 7 (5-HT7) has attracted significant attention as a potential drug target; due to its elucidated roles in conditions such as insomnia, schizophrenia, and more. Therefore, it is unsurprising that there has been relatively early efforts undertaken to develop a positron emission tomography (PET) imaging agent for said receptor system. PET can be clinically used to probe receptor systems in vivo, permitting information such as a drug's occupancy against this system to be investigated. This review focuses on the efforts towards the development of a 5-HT7R selective PET CNS tracer over the last 20 years, critically reflecting on applied strategies and commonly employed chemical frameworks and suggests future considerations that are needed to successfully develop a PET tracer for this clinically relevant target. This article is part of the special issue entitled ‘Serotonin Research: Crossing Scales and Boundaries’." @default.
- W2982171454 created "2019-11-01" @default.
- W2982171454 creator A5002608888 @default.
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- W2982171454 creator A5031340154 @default.
- W2982171454 creator A5056910266 @default.
- W2982171454 creator A5067261709 @default.
- W2982171454 date "2020-08-01" @default.
- W2982171454 modified "2023-10-14" @default.
- W2982171454 title "Towards selective CNS PET imaging of the 5-HT7 receptor system: Past, present and future" @default.
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