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• W2982173670 abstract "• We lack effective treatment for chronic rotator cuff tear. • We evaluated combined treatment with polydeoxyribonucleotides and microcurrent in a rabbit model. • The combination treatment showed marked regeneration for rotator cuff tear in gross morphologic, histological, and motion analysis. • Combined treatment with polydeoxyribonucleotides and microcurrent is effective to treat chronic rotator cuff tear in a rabbit model. Rotator cuff tendon tears (RCTTs) are common adult injuries. We hypothesized that a local injection of polydeoxyribonucleotide (PDRN) and microcurrent therapy (MIC) would be more effective in regenerating a tendon tear than PDRN administration alone. To evaluate the effect of PDRN combined with MIC on the regeneration of RCTTs in a rabbit subscapularis tendon chronic RCTT model. Rabbits ( n = 24) were allocated to 3 groups at 6 weeks after full-thickness RCTT (FTRCTT): 0.2 mL normal saline (G1-SAL); 0.2 mL PDRN with Sham MIC (G2-PDRN + Sham MIC); and 0.2 mL PDRN with MIC (G3-PDRN + MIC). All treatments were performed under ultrasound guidance. PDRN was injected weekly for 4 weeks and sham MIC or MIC was applied daily for 4 weeks after the first PDRN injection. In the G3-PDRN + MIC group, the mean (SD) subscapularis tendon tear size was continuously reduced from 1 week post-treatment to 4 weeks and was significantly decreased as compared with the other 2 groups [6.0 (1.5) vs. G1: 11.5 (1.8) and G2: 9.1 (1.6) mm 2 ; G3 vs. G1, P < 0.001; G3 vs. G2, P = 0.018]. The gross morphologic mean tendon tear size was significantly smaller in the G3-PDRN + MIC group than G1-SAL and G2-PDRN+ Sham MIC groups [8.8 (3.5) vs. 15.9 (2.3) and 12.4 (1.6) mm 2 ; G3 vs. G1, P < 0.001; G3 vs. G2, P = 0.03]. Mean values for regenerated collagen type 1 fibers, angiogenesis, and walking parameters were all greater for the G3-PDRN + MIC group than the other 2 groups based on histological examination and motion analysis [collagen type 1, G3: 1.60 (0.80) vs. G1: 0.45 (0.60), G2: 1.10 (0.74), G3 vs. G1, P < 0.001; G3 vs. G2, P = 0.002] [angiogenesis, G3: 2.44 (0.73) vs. G1: 0.80 (0.82) and G2: 2.06 (0.81), G3 vs. G1, P < 0.001; G3 vs. G2, P = 0.006] [walking distance, G3: 6391.4 (196.9) vs. G1: 4852.8 (137.3) and G2: 5514.4 (257.3) cm; G3 vs. G1, P < 0.001; G3 vs. G2, P < 0.001]. On gross morphologic, histological, and motion analysis, combined PDRN with MIC therapy was more effective than PDRN alone treating a rabbit model of chronic traumatic FTRCTT." @default.
• W2982173670 created "2019-11-01" @default.
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• W2982173670 date "2020-11-01" @default.
• W2982173670 modified "2023-09-26" @default.
• W2982173670 title "Synergic regenerative effects of polydeoxyribonucleotide and microcurrent on full-thickness rotator cuff healing in a rabbit model" @default.
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• W2982173670 doi "https://doi.org/10.1016/j.rehab.2019.09.010" @default.
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